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We present a numerical approximation technique for the analysis of continuous-time Markov chains that describe networks of biochemical reactions and play an important role in the stochastic modeling of biological systems. Our approach is…

Quantitative Methods · Quantitative Biology 2010-05-06 Thomas A. Henzinger , Maria Mateescu , Linar Mikeev , Verena Wolf

This paper studies algorithmic strategies to effectively reduce the number of infections in susceptible-infected-recovered (SIR) epidemic models. We consider a Markov chain SIR model and its two instantiations in the deterministic SIR…

Optimization and Control · Mathematics 2020-11-24 Yuhao Yi , Liren Shan , Philip E. Paré , Karl H. Johansson

In this paper, we consider an adaptive optimal control problem for an SIR/V epidemic model with human behavioral effects.We develop a model where effective management of infectious diseases are monitored by the means of non pharmaceutical…

Physics and Society · Physics 2025-12-09 Nuruzzaman Rahat , Abid Hossain , Muntasir Alam

We introduce a policy model coupled with the susceptible-infected-recovered (SIR) epidemic model to study interactions between policy-making and the dynamics of epidemics. We consider both single-region policies, as well as game-theoretic…

Optimization and Control · Mathematics 2024-08-06 Xia Li , Andrea L. Bertozzi , P. Jeffrey Brantingham , Yevgeniy Vorobeychik

Recently, a theory for stochastic optimal control in non-linear dynamical systems in continuous space-time has been developed (Kappen, 2005). We apply this theory to collaborative multi-agent systems. The agents evolve according to a given…

Multiagent Systems · Computer Science 2012-07-02 Wim Wiegerinck , Bart van den Broek , Hilbert Kappen

This paper investigates a sample-based solution to the hybrid mode control problem across non-differentiable and algorithmic hybrid modes. Our approach reasons about a set of hybrid control modes as an integer-based optimization problem…

Robotics · Computer Science 2026-03-09 Yilang Liu , Haoxiang You , Ian Abraham

Effective epidemic control is crucial for mitigating the spread of infectious diseases, particularly when pharmaceutical interventions such as vaccines or treatments are limited. Non-pharmaceutical strategies, including mobility…

Physics and Society · Physics 2025-12-03 Deborah Volpe , Giacomo Orlandi , Mattia Boggio , Carlo Novara , Lorenzo Zino , Giovanna Turvani

We present a data-driven optimal control approach which integrates the reported partial data with the epidemic dynamics for COVID-19. We use a basic Susceptible-Exposed-Infectious-Recovered (SEIR) model, the model parameters are…

Optimization and Control · Mathematics 2020-12-22 Hailiang Liu , Xuping Tian

Mathematical modelling can help to explain the nature and dynamics of infection transmissions, as well as support a policy for implementing those strategies that are most likely to bring public health and economic benefits. The paper…

Optimization and Control · Mathematics 2015-09-01 Roman Denysiuk , Cristiana J. Silva , Delfim F. M. Torres

Continuous-time Markov process models of contagions are widely studied, not least because of their utility in predicting the evolution of real-world contagions and in formulating control measures. It is often the case, however, that…

Physics and Society · Physics 2016-11-23 Peter G. Fennell , Sergey Melnik , James P. Gleeson

In this paper, we study the dynamics of epidemic processes taking place in adaptive networks of arbitrary topology. We focus our study on the adaptive susceptible-infected-susceptible (ASIS) model, where healthy individuals are allowed to…

Social and Information Networks · Computer Science 2016-06-29 Masaki Ogura , Victor M. Preciado

The SIS (susceptible-infected-susceptible) epidemic model on an arbitrary network, without making approximations, is a $2^n$-state Markov chain with a unique absorbing state (the all-healthy state). This makes analysis of the SIS model and,…

Social and Information Networks · Computer Science 2019-01-21 Navid Azizan Ruhi , Christos Thrampoulidis , Babak Hassibi

The COVID-19 pandemic has posed a policy making crisis where efforts to slow down or end the pandemic conflict with economic priorities. This paper provides mathematical analysis of optimal disease control policies with idealized…

Optimization and Control · Mathematics 2021-02-16 Aaron Z. Palmer , Zelda B. Zabinsky , Shan Liu

The main aim to build models capable of simulating the spreading of infectious diseases is to control them. And along this way, the key to find the optimal strategy for disease control is to obtain a large number of simulations of disease…

Social and Information Networks · Computer Science 2022-04-22 Ting Wang , Gui-Yun Li , Xin-Hui Li , Chi-Chun Zhou , Yuan-Yuan Wang , Li-Juan Li , Yan-Ting Yang

Though switched dynamical systems have shown great utility in modeling a variety of physical phenomena, the construction of an optimal control of such systems has proven difficult since it demands some type of optimal mode scheduling. In…

Optimization and Control · Mathematics 2014-02-04 Ramanarayan Vasudevan , Humberto Gonzalez , Ruzena Bajcsy , S. Shankar Sastry

Trajectory optimization is a fundamental stochastic optimal control problem. This paper deals with a trajectory optimization approach for dynamical systems subject to measurement noise that can be fitted into linear time-varying stochastic…

Systems and Control · Electrical Eng. & Systems 2021-08-24 Prakash Mallick , Zhiyong Chen

A probabilistic approach to the epidemic evolution on realistic social-contact networks allows for characteristic differences among subjects, including the individual number and structure of social contacts, and the heterogeneity of the…

Social and Information Networks · Computer Science 2022-02-11 Jan B. Broekaert , Davide La Torre , Faizal Hafiz

We study first order necessary conditions for an optimal control problem of a Susceptible-Infected-Recovered (SIR) model with limitations on the duration of the quarantine. The control is done by means of the reproduction number, i.e., the…

We present a control framework for stochastic compartmental models in epidemiology. In this framework, rather than directly controlling the stochastic system, we perform optimal control of an associated Fokker-Planck equation, with the goal…

Optimization and Control · Mathematics 2026-04-06 Christian Parkinson , Souvik Roy

This paper investigates an aperiodic distributed model predictive control approach for multi-agent systems (MASs) in which parameterized synchronization constraints is considered and an innovative self-triggered criterion is constructed.…

Systems and Control · Electrical Eng. & Systems 2024-05-21 Qianqian Chen , Shaoyuan Li
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