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Reliable uncertainty quantification (UQ) is essential when employing large language models (LLMs) in high-risk domains such as clinical question answering (QA). In this work, we evaluate uncertainty estimation methods for clinical QA…

Computation and Language · Computer Science 2026-01-27 Alberto Testoni , Iacer Calixto

Uncertainty quantification (UQ) is the process of systematically determining and characterizing the degree of confidence in computational model predictions. In the context of systems biology, especially with dynamic models, UQ is crucial…

Machine Learning · Statistics 2024-10-29 Alberto Portela , Julio R. Banga , Marcos Matabuena

Space-filling designs are commonly used in computer experiments to fill the space of inputs so that the input-output relationship can be accurately estimated. However, in certain applications such as inverse design or feature-based…

Methodology · Statistics 2023-09-08 Shangkun Wang , Adam P. Generale , Surya R. Kalidindi , V. Roshan Joseph

We investigate unitary and state $t$-designs from a computational complexity perspective. First, we address the problems of computing frame potentials that characterize (approximate) $t$-designs. We present a quantum algorithm for computing…

Quantum Physics · Physics 2025-09-17 Yoshifumi Nakata , Yuki Takeuchi , Martin Kliesch , Andrew Darmawan

In scientific inference problems, the underlying statistical modeling assumptions have a crucial impact on the end results. There exist, however, only a few automatic means for validating these fundamental modelling assumptions. The…

Methodology · Statistics 2019-05-21 Andreas Svensson , Dave Zachariah , Petre Stoica , Thomas B. Schön

This paper introduces the method of composite quantile factor model for factor analysis in high-dimensional panel data. We propose to estimate the factors and factor loadings across multiple quantiles of the data, allowing the estimates to…

Econometrics · Economics 2024-12-03 Xiao Huang

The paper addresses design of experiments for classifying the input factors of a multi-variate function into negligible, linear and other (non-linear/interaction) factors. We give constructive procedures for completing the definition of the…

Methodology · Statistics 2013-07-09 Jean-Marc Fédou , Maria João Rendas

We introduce new measures of decoherence appropriate for evaluation of quantum computing designs. Environment-induced deviation of a quantum system's evolution from controlled dynamics is quantified by a single numerical measure. This…

Mesoscale and Nanoscale Physics · Physics 2010-10-12 Leonid Fedichkin , Arkady Fedorov , Vladimir Privman

Quantum coherence is a fundamental manifestation of the quantum superposition principle. Recently, Baumgratz \emph{et al}. [Phys. Rev. Lett. \textbf{113}, 140401 (2014)] presented a rigorous framework to quantify coherence from the view of…

Quantum Physics · Physics 2017-08-02 Xianfei Qi , Ting Gao , Fengli Yan

This paper examines the potential role of unit consistency as a system design principle. Unit-consistent generalized matrix inverses and unit-invariant matrix decompositions are derived in support of this principle. Applications of the…

Numerical Analysis · Computer Science 2017-07-12 Jeffrey Uhlmann

Uncertainty relations and quantum entanglement are pivotal concepts in quantum theory. Beyond their fundamental significance in shaping our understanding of the quantum world, they also underpin crucial applications in quantum information…

Quantum Physics · Physics 2023-12-18 Yundu Zhao , Shan Huang , Shengjun Wu

Quadratic discriminant analysis (QDA) is a simple method to classify a subject into two populations, and was proven to perform as well as the Bayes rule when the data dimension p is fixed. The main purpose of this paper is to examine the…

Statistics Theory · Mathematics 2018-08-31 Qing Yang , Guang Cheng

Hybrid quantum and classical learning aims to couple quantum feature maps with the robustness of classical neural networks, yet most architectures treat the quantum circuit as an isolated feature extractor and merge its measurements with…

Machine Learning · Computer Science 2025-12-23 Azadeh Alavi , Fatemeh Kouchmeshki , Abdolrahman Alavi

In this paper, we proposes the construction methods of sliced space-filling design when the quantitative factors are mixture components. Leveraging the representative points framework for distribution and energy distance decomposition…

Statistics Theory · Mathematics 2025-09-29 Zikang Xiong , Hong Qin , Yuning Huang , Jianhui Ning

Planning quality assurance (QA) activities in a systematic way and controlling their execution are challenging tasks for companies that develop software or software-intensive systems. Both require estimation capabilities regarding the…

Software Engineering · Computer Science 2014-01-14 Michael Kläs , Haruka Nakao , Frank Elberzhager , Jürgen Münch

As machine learning (ML) models are increasingly deployed in high-stakes domains, trustworthy uncertainty quantification (UQ) is critical for ensuring the safety and reliability of these models. Traditional UQ methods rely on specifying a…

Machine Learning · Statistics 2025-05-14 Abhineet Agarwal , Michael Xiao , Rebecca Barter , Omer Ronen , Boyu Fan , Bin Yu

Quantitative aspects of computation are related to the use of both physical and mathematical quantities, including time, performance metrics, probability, and measures for reliability and security. They are essential in characterizing the…

Programming Languages · Computer Science 2020-01-22 Alessandro Aldini

Quantum Key Distribution (QKD) is rapidly transitioning from cutting-edge laboratory research to real-world deployment in established communication networks. Although QKD promises future-proof security, practical challenges stil exist due…

Machine learning methods are increasingly widely used in high-risk settings such as healthcare, transportation, and finance. In these settings, it is important that a model produces calibrated uncertainty to reflect its own confidence and…

Artificial Intelligence · Computer Science 2022-09-09 Sophia Sun

Expert systems often operate in domains characterized by class-imbalanced tabular data, where detecting rare but critical instances is essential for safety and reliability. While conventional approaches, such as cost-sensitive learning,…

Machine Learning · Computer Science 2025-06-23 Md Abrar Jahin , Adiba Abid , M. F. Mridha
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