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Major depressive disorder is a serious and heterogeneous psychiatric disorder that needs accurate diagnosis. Resting-state functional MRI (rsfMRI), which captures multiple perspectives on brain structure, function, and connectivity, is…

Machine Learning · Computer Science 2023-08-21 Yunsong Luo , Wenyu Chen , Ling Zhan , Jiang Qiu , Tao Jia

Time series data constitutes a distinct and growing problem in machine learning. As the corpus of time series data grows larger, deep models that simultaneously learn features and classify with these features can be intractable or…

Machine Learning · Computer Science 2018-01-25 Hugh Chen , Scott Lundberg , Su-In Lee

That physiological oscillations of various frequencies are present in fMRI signals is the rule, not the exception. Herein, we propose a novel theoretical framework, spatio-temporal Granger causality, which allows us to more reliably and…

Applications · Statistics 2018-03-15 Qiang Luo , Wenlian Lu , Wei Cheng , Pedro A. Valdes-Sosa , Xiaotong Wen , Mingzhou Ding , Jianfeng Feng

Longitudinal fMRI datasets hold great promise for the study of neurodegenerative diseases, but realizing their potential depends on extracting accurate fMRI-based brain measures in individuals over time. This is especially true for rare,…

Autism spectrum disorder (ASD) is a neurological and developmental disorder that affects social and communicative behaviors. It emerges in early life and is generally associated with lifelong disabilities. Thus, accurate and early diagnosis…

Image and Video Processing · Electrical Eng. & Systems 2025-02-24 Peiyu Duan , Nicha C. Dvornek , Jiyao Wang , Lawrence H. Staib , James S. Duncan

This paper considers the use of machine learning algorithms for predicting cocaine use based on magnetic resonance imaging (MRI) connectomic data. The study utilized functional MRI (fMRI) and diffusion MRI (dMRI) data collected from 275…

Several studies claim that listening to Mozart music affects cognition and can be used to treat neurological conditions like epilepsy. Research into this Mozart effect has not addressed how dynamic interactions between brain networks, i.e.…

Systems and Control · Electrical Eng. & Systems 2020-10-16 Rik J. C. van Esch , Shengling Shi , Antoine Bernas , Svitlana Zinger , Albert P. Aldenkamp , Paul M. J. Van den Hof

Functional magnetic resonance imaging (fMRI) time series are known to exhibit long-range temporal dependencies that challenge traditional modeling approaches. In this study, we propose a novel computational pipeline to characterize and…

Applications · Statistics 2025-08-19 Yasaman Shahhosseini , Cédric Beaulac , Farouk S. Nathoo , Michelle F. Miranda

EEG-based emotion recognition holds significant promise for objective diagnosis of mood disorders. Graph neural networks (GNNs) have emerged as the dominant paradigm for modeling inter-channel dependencies in EEG, yet existing approaches…

Machine Learning · Computer Science 2026-05-26 Ziyi Wang , Dongyang Kuang

While most classical approaches to Granger causality detection assume linear dynamics, many interactions in real-world applications, like neuroscience and genomics, are inherently nonlinear. In these cases, using linear models may lead to…

Machine Learning · Statistics 2021-03-16 Alex Tank , Ian Covert , Nicholas Foti , Ali Shojaie , Emily Fox

Substantial evidence indicates that major psychiatric disorders are associated with distributed neural dysconnectivity, leading to strong interest in using neuroimaging methods to accurately predict disorder status. In this work, we are…

Machine Learning · Statistics 2014-03-26 Takanori Watanabe , Daniel Kessler , Clayton Scott , Michael Angstadt , Chandra Sripada

Multi-modal neuroimaging technology has greatlly facilitated the efficiency and diagnosis accuracy, which provides complementary information in discovering objective disease biomarkers. Conventional deep learning methods, e.g. convolutional…

Image and Video Processing · Electrical Eng. & Systems 2022-10-26 Yanwu Yang , Xutao Guo , Zhikai Chang , Chenfei Ye , Yang Xiang , Ting Ma

In a real-life setting, little is known regarding the effectiveness of statins for primary prevention among older adults, and analysis of observational data can add crucial information on the benefits of actual patterns of use. Latent class…

Methodology · Statistics 2023-10-18 Awa Diop , Caroline Sirois , Jason Robert Guertin , Denis Talbot

Since interactions in neural systems occur across multiple temporal scales, it is likely that information flow will exhibit a multiscale structure, thus requiring a multiscale generalization of classical temporal precedence causality…

Quantitative Methods · Quantitative Biology 2017-07-13 Sebastiano Stramaglia , Iege Bassez , Luca Faes , Daniele Marinazzo

Granger causal modeling is an emerging topic that can uncover Granger causal relationship behind multivariate time series data. In many real-world systems, it is common to encounter a large amount of multivariate time series data collected…

Machine Learning · Computer Science 2021-02-11 Yunfei Chu , Xiaowei Wang , Jianxin Ma , Kunyang Jia , Jingren Zhou , Hongxia Yang

Longitudinal biomarker data and health outcomes are routinely collected in many studies to assess how biomarker trajectories predict health outcomes. Existing methods primarily focus on mean biomarker profiles, treating variability as a…

Granger Causality (GC) is widely used in neuroimaging to estimate directed statistical dependence among brain regions using time series of brain activity. An important issue is that functional MRI (fMRI) measures brain activity indirectly…

Neurons and Cognition · Quantitative Biology 2023-12-05 Leonardo Novelli , Lionel Barnett , Anil Seth , Adeel Razi

Latent confounding has been a long-standing obstacle for causal reasoning from observational data. One popular approach is to model the data using acyclic directed mixed graphs (ADMGs), which describe ancestral relations between variables…

Machine Learning · Computer Science 2023-03-23 Matthew Ashman , Chao Ma , Agrin Hilmkil , Joel Jennings , Cheng Zhang

Dependence between nodes in a network is an important concept that pervades many areas including finance, politics, sociology, genomics and the brain sciences. One way to characterize dependence between components of a multivariate time…

Machine Learning · Statistics 2024-08-08 Malik Shahid Sultan , Samuel Horvath , Hernando Ombao

Understanding the dynamics of functional brain connectivity patterns using noninvasive neuroimaging techniques is an important focus in human neuroscience. Vector autoregressive (VAR) processes and Granger causality analysis (GCA) have been…

Applications · Statistics 2022-09-16 Jingjing Fan , Kevin Sitek , Bharath Chandrasekaran , Abhra Sarkar