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We introduce a Bayesian sequential data assimilation method for COVID-19 forecasting. It is assumed that suitable transmission, epidemic and observation models are available and previously validated and the transmission and epidemic models…

Epidemic models play a key role in understanding and responding to the emerging COVID-19 pandemic. Widely used compartmental models are static and are of limited use to evaluate intervention strategies with the emerging pandemic. Applying…

Populations and Evolution · Quantitative Biology 2021-01-01 Shuo Wang , Xian Yang , Ling Li , Philip Nadler , Rossella Arcucci , Yuan Huang , Zhongzhao Teng , Yike Guo

The COVID-19 pandemic and its multiple outbreaks have challenged governments around the world. Much of the epidemiological modeling was based on pre-pandemic contact information of the population, which changed drastically due to…

Populations and Evolution · Quantitative Biology 2023-09-15 Santiago Rosa , Manuel Pulido , Juan Ruiz , Tadeo Cocucci

The COVID-19 pandemic provides new motivation for a classic problem in epidemiology: estimating the empirical rate of transmission during an outbreak (formally, the time-varying reproduction number) from case counts. While standard methods…

Methodology · Statistics 2020-12-08 Bryan Wilder , Michael J. Mina , Milind Tambe

We propose a robust parameter estimation method for dynamical systems based on Statistical Learning techniques which aims to estimate a set of parameters that well fit the dynamics in order to obtain robust evidences about the qualitative…

Methodology · Statistics 2021-02-26 Diego Marcondes

The role of epidemiological models is crucial for informing public health officials during a public health emergency, such as the COVID-19 pandemic. However, traditional epidemiological models fail to capture the time-varying effects of…

Methodology · Statistics 2022-06-17 Adam Spannaus , Theodore Papamarkou , Samantha Erwin , J. Blair Christian

We demonstrate the ability of statistical data assimilation to identify the measurements required for accurate state and parameter estimation in an epidemiological model for the novel coronavirus disease COVID-19. Our context is an effort…

Populations and Evolution · Quantitative Biology 2020-08-04 Eve Armstrong , Manuela Runge , Jaline Gerardin

For many infectious disease outbreaks, the at-risk population changes their behavior in response to the outbreak severity, causing the transmission dynamics to change in real-time. Behavioral change is often ignored in epidemic modeling…

Methodology · Statistics 2023-10-25 Caitlin Ward , Rob Deardon , Alexandra M. Schmidt

Predicting the spread of vector-borne diseases in response to incursions requires knowledge of both host and vector demographics in advance of an outbreak. Whereas host population data is typically available, for novel disease introductions…

Populations and Evolution · Quantitative Biology 2015-06-02 Chris Jewell , Richard Brown

In this article, we consider a dynamic epidemiology model for the spread of the COVID-19 infection. Starting from the classical SEIR model, the model is modified so as to better describe characteristic features of the underlying pathogen…

Populations and Evolution · Quantitative Biology 2020-05-22 Daniela Calvetti , Alexander Hoover , Johnie Rose , Erkki Somersalo

This paper extends the canonical model of epidemiology, the SIRD model, to allow for time-varying parameters for real-time measurement and prediction of the trajectory of the Covid-19 pandemic. Time variation in model parameters is captured…

Econometrics · Economics 2023-02-01 Cem Cakmakli , Yasin Simsek

During an infectious disease outbreak, public health decision-makers require real-time monitoring of disease transmission to respond quickly and intelligently. In these settings, a key measure of transmission is the instantaneous…

Methodology · Statistics 2025-02-07 Gary Hettinger , David Rubin , Jing Huang

Data assimilation refers to the process of obtaining an estimate of a system's state using a model for the system's time evolution and a time series of measurements that are possibly noisy and incomplete. However, for practical reasons, the…

Chaotic Dynamics · Physics 2007-05-23 Matthew Cornick , Brian Hunt , Edward Ott , Michael F. Schatz

The long duration of the COVID-19 pandemic allowed for multiple bursts in the infection and death rates, the so-called epidemic waves. This complex behavior is no longer tractable by simple compartmental model and requires more…

The acute phase of the Covid-19 pandemic has made apparent the need for decision support based upon accurate epidemic modeling. This process is substantially hampered by under-reporting of cases and related data incompleteness issues. In…

Applications · Statistics 2026-03-10 Anastasios Apsemidis , Nikolaos Demiris

Epidemiological models with constant parameters may not capture satisfactory infection patterns in the presence of pharmaceutical and non-pharmaceutical mitigation measures during a pandemic, since infectiousness is a function of time. In…

Populations and Evolution · Quantitative Biology 2022-05-16 K. D. Olumoyin , A. Q. M. Khaliq , K. M. Furati

Tracking the spread of infectious disease during a pandemic has posed a great challenge to the governments and health sectors on a global scale. To facilitate informed public health decision-making, the concerned parties usually rely on…

Methodology · Statistics 2023-06-05 Tejasv Bedi , Yanxun Xu , Qiwei Li

Data assimilation is an iterative approach to the problem of estimating the state of a dynamical system using both current and past observations of the system together with a model for the system's time evolution. Rather than solving the…

Data Analysis, Statistics and Probability · Physics 2007-05-23 Brian R. Hunt , Eric J. Kostelich , Istvan Szunyogh

Modeling the spread of COVID-19 is crucial for informing public health policy. All models for COVID-19 epidemiology rely on parameters describing the dynamics of the infection process. The meanings of epidemiological parameters like R_0,…

Other Quantitative Biology · Quantitative Biology 2020-07-13 Yinon M. Bar-On , Ron Sender , Avi I. Flamholz , Rob Phillips , Ron Milo

The effective reproduction number $R_t$ measures an infectious disease's transmissibility as the number of secondary infections in one reproduction time in a population having both susceptible and non-susceptible hosts. Current approaches…

Methodology · Statistics 2020-12-04 Marcos A. Capistrán , Antonio Capella , J. Andrés Christen
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