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In this paper, we explore the solvability and the optimal control problem for a compartmental model based on reaction-diffusion partial differential equations describing a transmissible disease. The nonlinear model takes into account the…

Optimization and Control · Mathematics 2023-08-25 Pierluigi Colli , Gianni Gilardi , Gabriela Marinoschi

The evaluation of infectious disease processes on radiologic images is an important and challenging task in medical image analysis. Pulmonary infections can often be best imaged and evaluated through computed tomography (CT) scans, which…

Image and Video Processing · Electrical Eng. & Systems 2021-09-24 Ashia Lewis , Evanjelin Mahmoodi , Yuyue Zhou , Megan Coffee , Elena Sizikova

In this paper, we study an optimal control problem of a communicable disease in a prison population. In order to control the spread of the disease inside a prison, we consider an active case-finding strategy, consisting on screening a…

Optimization and Control · Mathematics 2020-11-06 Pedro Gajardo , Victor Riquelme , Diego Vicencio

We consider a controlled reaction-diffusion equation, motivated by a pest eradication problem. Our goal is to derive a simpler model, describing the controlled evolution of a contaminated set. In this direction, the first part of the paper…

Optimization and Control · Mathematics 2021-08-24 Alberto Bressan , Maria Teresa Chiri , Najmeh Salehi

In this study, we present a new epidemiological model, with contamination from confirmed and unreported. We also compute equilibria and study their stability without intervention strategies. Optimal control theory has proven to be a…

Populations and Evolution · Quantitative Biology 2020-08-14 Fulgence Mansal , Mouhamadou A. M. T. Baldé , Alpha O. Bah

We propose and investigate a delayed model that studies the relationship between HIV and the immune system during the natural course of infection and in the context of antiviral treatment regimes. Sufficient criteria for local asymptotic…

Optimization and Control · Mathematics 2018-03-19 Diana Rocha , Cristiana J. Silva , Delfim F. M. Torres

In this paper, a methodology for the automated detection and classification of Tuberculosis(TB) is presented. Tuberculosis is a disease caused by mycobacterium which spreads through the air and attacks low immune bodies easily. Our…

Artificial Intelligence · Computer Science 2011-08-05 Asha. T , S. Natarajan , K. N. B. Murthy

This study explores the application of machine learning models, specifically a pretrained ResNet-50 model and a general SqueezeNet model, in diagnosing tuberculosis (TB) using chest X-ray images. TB, a persistent infectious disease…

Computer Vision and Pattern Recognition · Computer Science 2025-12-03 Daanish Hindustani , Sanober Hindustani , Preston Nguyen

We present an application of optimal control theory to Dengue epidemics. This epidemiologic disease is an important theme in tropical countries due to the growing number of infected individuals. The dynamic model is described by a set of…

Optimization and Control · Mathematics 2010-08-27 Helena Sofia Rodrigues , M. Teresa T. Monteiro , Delfim F. M. Torres

Automatic classification of active tuberculosis from chest X-ray images has the potential to save lives, especially in low- and mid-income countries where skilled human experts can be scarce. Given the lack of available labeled data to…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Özgür Acar Güler , Manuel Günther , André Anjos

Tuberculosis (TB) is an infectious disease transmitted through the respiratory system. China is one of the countries with a high burden of TB. Since 2004, an average of more than 800,000 cases of active TB have been reported each year in…

Applications · Statistics 2023-04-03 Chuanqing Xu , Kedeng Cheng , Yu Wang , Songbai Guo , Maoxing Liu , Xiaojing Wang , Zhiguo Zhang

We consider epidemic extinction in finite networks with broad variation in local connectivity. Generalizing the theory of large fluctuations to random networks with a given degree distribution, we are able to predict the most probable, or…

Adaptation and Self-Organizing Systems · Physics 2016-07-07 Jason Hindes , Ira B. Schwartz

We consider the problem of influence maximization in fixed networks for contagion models in an adversarial setting. The goal is to select an optimal set of nodes to seed the influence process, such that the number of influenced nodes at the…

Social and Information Networks · Computer Science 2019-01-23 Justin Khim , Varun Jog , Po-Ling Loh

In this manuscript we apply stochastic modeling to investigate the risk of reactivation of latent mycobacterial infections in patients undergoing treatment with tumor necrosis factor inhibitors. First, we review the perspective proposed by…

Medical Physics · Physics 2013-04-22 Elena Agliari , Lorenzo Asti , Adriano Barra , Rossana Scrivo , Guido Valesini , Robert S. Wallis

In this paper, an SIR epidemic model with variable size of population is considered. We study optimal control problem for an SIR model with "vaccination" and "treatment" as controls. It is shown that an optimal control exists. We have…

Optimization and Control · Mathematics 2016-12-28 Olga Klimenkova

Nowadays, epidemic models provide an appropriate tool for describing the propagation of biological viruses in human or animal populations, or rumours and other kinds of information in social networks and malware in both computer and ad hoc…

Optimization and Control · Mathematics 2020-07-21 Vladislav Taynitskiy , Elena Gubar , Denis Fedyanin , Ilya Petrov , Quanyan Zhu

The COVID-19 pandemic has posed a policy making crisis where efforts to slow down or end the pandemic conflict with economic priorities. This paper provides mathematical analysis of optimal disease control policies with idealized…

Optimization and Control · Mathematics 2021-02-16 Aaron Z. Palmer , Zelda B. Zabinsky , Shan Liu

We study the problem of a policymaker who aims at taming the spread of an epidemic while minimizing its associated social costs. The main feature of our model lies in the fact that the disease's transmission rate is a diffusive stochastic…

Optimization and Control · Mathematics 2020-11-04 Salvatore Federico , Giorgio Ferrari

Tuberculosis (TB) is a major global health challenge, and is compounded by co-morbidities such as HIV, diabetes, and anemia, which complicate treatment outcomes and contribute to heterogeneous patient responses. Traditional models of TB…

Machine Learning · Computer Science 2024-11-19 Ethan Wu , Caleb Ellington , Ben Lengerich , Eric P. Xing

A distributed optimal control problem for an extended model of phase field type for tumor growth is addressed. In this model, the chemotaxis effects are also taken into account. The control is realized by two control variables that design…

Analysis of PDEs · Mathematics 2021-03-23 Pierluigi Colli , Andrea Signori , Jürgen Sprekels