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Detecting cancer manually in whole slide images requires significant time and effort on the laborious process. Recent advances in whole slide image analysis have stimulated the growth and development of machine learning-based approaches…
In recent years, large scale data intensive astronomical surveys have resulted in more detailed images being produced than scientists can manually classify. Even attempts to crowd-source this work will soon be outpaced by the large amount…
Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL)…
While deep learning strategies achieve outstanding results in computer vision tasks, one issue remains: The current strategies rely heavily on a huge amount of labeled data. In many real-world problems, it is not feasible to create such an…
Traditional image clustering methods take a two-step approach, feature learning and clustering, sequentially. However, recent research results demonstrated that combining the separated phases in a unified framework and training them jointly…
Data labeling is often the most challenging task when developing computational pathology models. Pathologist participation is necessary to generate accurate labels, and the limitations on pathologist time and demand for large, labeled…
Sharing images online poses security threats to a wide range of users due to the unawareness of privacy information. Deep features have been demonstrated to be a powerful representation for images. However, deep features usually suffer from…
We consider the problem of data clustering with unidentified feature quality and when a small amount of labelled data is provided. An unsupervised sparse clustering method can be employed in order to detect the subgroup of features…
Recent advances in whole-slide image (WSI) scanners and computational capabilities have significantly propelled the application of artificial intelligence in histopathology slide analysis. While these strides are promising, current…
Unsupervised learning has been a long-standing goal of machine learning and is especially important for medical image analysis, where the learning can compensate for the scarcity of labeled datasets. A promising subclass of unsupervised…
Cancer is one of the deadliest diseases worldwide. Accurate diagnosis and classification of cancer subtypes are indispensable for effective clinical treatment. Promising results on automatic cancer subtyping systems have been published…
Local discriminative representation is needed in many medical image analysis tasks such as identifying sub-types of lesion or segmenting detailed components of anatomical structures. However, the commonly applied supervised representation…
The task of clustering a set of objects based on multiple sources of data arises in several modern applications. We propose an integrative statistical model that permits a separate clustering of the objects for each data source. These…
Whole slide images (WSIs) are the gold standard for pathological diagnosis and sub-typing. Current main-stream two-step frameworks employ offline feature encoders trained without domain-specific knowledge. Among them, attention-based…
Can we automatically group images into semantically meaningful clusters when ground-truth annotations are absent? The task of unsupervised image classification remains an important, and open challenge in computer vision. Several recent…
Grading precancerous lesions on whole slide images is a challenging task: the continuous space of morphological phenotypes makes clear-cut decisions between different grades often difficult, leading to low inter- and intra-rater agreements.…
Unsupervised machine learning, and in particular data clustering, is a powerful approach for the analysis of datasets and identification of characteristic features occurring throughout a dataset. It is gaining popularity across scientific…
Recently, deep neural networks have greatly advanced histopathology image segmentation but usually require abundant annotated data. However, due to the gigapixel scale of whole slide images and pathologists' heavy daily workload, obtaining…
Recent developed deep unsupervised methods allow us to jointly learn representation and cluster unlabelled data. These deep clustering methods mainly focus on the correlation among samples, e.g., selecting high precision pairs to gradually…
Glioblastoma is profoundly heterogeneous in regional microstructure and vasculature. Characterizing the spatial heterogeneity of glioblastoma could lead to more precise treatment. With unsupervised learning techniques, glioblastoma…