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In recent years, several particle-based stochastic simulation algorithms (PSSA) have been developed to study the spatially resolved dynamics of biochemical networks at a molecular scale. A challenge all these approaches have to address is…

Quantitative Methods · Quantitative Biology 2011-07-04 Thorsten Prüstel , Martin Meier-Schellersheim

Statistical (machine learning) tools for equation discovery require large amounts of data that are typically computer generated rather than experimentally observed. Multiscale modeling and stochastic simulations are two areas where learning…

Machine Learning · Statistics 2021-03-17 Joseph Bakarji , Daniel M. Tartakovsky

This article presents a novel method for causal discovery with generalized structural equation models suited for analyzing diverse types of outcomes, including discrete, continuous, and mixed data. Causal discovery often faces challenges…

Methodology · Statistics 2023-10-26 Minjie Wang , Xiaotong Shen , Wei Pan

The emergence of complex behaviors in cellular automata is an area that has been widely developed in recent years with the intention to generate and analyze automata that produce space-moving patterns or gliders that interact in a periodic…

Coarse-grained molecular dynamics often sacrifices accuracy and transferability for computational efficiency, but the use of machine learned potentials is helping coarse-grained models attain performance on par with atomistic molecular…

Chemical Physics · Physics 2026-02-17 Abigail Park , Shriram Chennakesavalu , Grant M. Rotskoff

Nowadays, Cellular Neural Networks (CNN) are practically implemented in parallel, analog computers, showing a fast developing trend. Physicist must be aware that such computers are appropriate for solving in an elegant manner practically…

Disordered Systems and Neural Networks · Physics 2016-02-17 Mária Ercsey-Ravasz , Tamás Roska , Zoltán Néda

Gaussian Process (GP) kernels are central to Bayesian optimization (BO), yet designing effective kernels for high-dimensional problems still relies on extensive manual engineering. Existing automated approaches struggle in high dimensions…

Machine Learning · Computer Science 2026-05-21 Taeyoung Yun , Woocheol Shin , Inhyuck Song , Jaewoo Lee , Jinkyoo Park

Tracking of plant cells in images obtained by microscope is a challenging problem due to biological phenomena such as large number of cells, non-uniform growth of different layers of the tightly packed plant cells and cell division.…

Computer Vision and Pattern Recognition · Computer Science 2023-09-22 Md Shazid Islam , Arindam Dutta , Calvin-Khang Ta , Kevin Rodriguez , Christian Michael , Mark Alber , G. Venugopala Reddy , Amit K. Roy-Chowdhury

Coarse-graining is a molecular modeling technique in which an atomistic system is represented in a simplified fashion that retains the most significant system features that contribute to a target output, while removing the degrees of…

A generalized understanding of protein dynamics is an unsolved scientific problem, the solution of which is critical to the interpretation of the structure-function relationships that govern essential biological processes. Here, we approach…

We propose, and illustrate via a neural network example, two different approaches to coarse-graining large heterogeneous networks. Both approaches are inspired from, and use tools developed in, methods for uncertainty quantification in…

Adaptation and Self-Organizing Systems · Physics 2016-11-03 Minseok Choi , Tom Bertalan , Carlo R. Laing , Ioannis G. Kevrekidis

Coarse-graining or model reduction is a term describing a range of approaches used to extend the time-scale of molecular simulations by reducing the number of degrees of freedom. In the context of molecular simulation, standard…

Dynamical Systems · Mathematics 2023-11-14 Thomas Hudson , Xingjie Helen Li

We propose a data-driven, coarse-graining formulation in the context of equilibrium statistical mechanics. In contrast to existing techniques which are based on a fine-to-coarse map, we adopt the opposite strategy by prescribing a…

Machine Learning · Statistics 2017-02-01 Markus Schöberl , Nicholas Zabaras , Phaedon-Stelios Koutsourelakis

Inspired by cellular growth and self-organization, Neural Cellular Automata (NCAs) have been capable of "growing" artificial cells into images, 3D structures, and even functional machines. NCAs are flexible and robust computational systems…

Neural and Evolutionary Computing · Computer Science 2022-05-16 Shyam Sudhakaran , Elias Najarro , Sebastian Risi

We created two dimensional hexagonal cellular automata to obtain complexity. Considering the game of life rules, Wolfram's works about life-like structures and John von Neumann's self-replication, self-maintenance, self-reproduction…

Cellular Automata and Lattice Gases · Physics 2023-02-28 Vural Erdogan

Cellular automata (CA) have been found as an attractive modeling tool for various applications, such as, pattern recognition, image processing, data compression, encryption, and specially for VLSI design & test. For such applications,…

Formal Languages and Automata Theory · Computer Science 2013-11-28 Sukanta Das , Biplab K Sikdar

Graph Neural Networks (GNNs) have demonstrated significant achievements in processing graph data, yet scalability remains a substantial challenge. To address this, numerous graph coarsening methods have been developed. However, most…

Machine Learning · Computer Science 2024-12-19 Shuyin Xia , Xinjun Ma , Zhiyuan Liu , Cheng Liu , Sen Zhao , Guoyin Wang

We say that a Cellular Automata (CA) is coalescing when its execution on two distinct (random) initial configurations in the same asynchronous mode (the same cells are updated in each configuration at each time step) makes both…

Cellular Automata and Lattice Gases · Physics 2007-05-23 Jean-Baptiste Rouquier , Michel Morvan

We exhaustively explore the reprogrammability capabilities and the intrinsic universality of the Cartesian product $P \times C$ of the space $P$ of all possible computer programs of increasing size and the space $C$ of all possible…

Formal Languages and Automata Theory · Computer Science 2018-02-02 Jürgen Riedel , Hector Zenil

We describe a class of cellular automata (CAs) that are end-to-end differentiable. DCAs interpolate the behavior of ordinary CAs through rules that act on distributions of states. The gradient of a DCA with respect to its parameters can be…

Discrete Mathematics · Computer Science 2017-09-01 Carlos Martin