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Enriching existing medical terminology knowledge bases (KBs) is an important and never-ending work for clinical research because new terminology alias may be continually added and standard terminologies may be newly renamed. In this paper,…

Computation and Language · Computer Science 2019-09-04 Jiaying Zhang , Zhixing Zhang , Huanhuan Zhang , Zhiyuan Ma , Yangming Zhou , Ping He

Exploring the effects a chemical compound has on a species takes a considerable experimental effort. Appropriate methods for estimating and suggesting new effects can dramatically reduce the work needed to be done by a laboratory. In this…

Artificial Intelligence · Computer Science 2019-11-12 Erik Bryhn Myklebust , Ernesto Jimenez-Ruiz , Jiaoyan Chen , Raoul Wolf , Knut Erik Tollefsen

Identifying and discovering drug-target interactions(DTIs) are vital steps in drug discovery and development. They play a crucial role in assisting scientists in finding new drugs and accelerating the drug development process. Recently,…

Quantitative Methods · Quantitative Biology 2023-11-15 Wenting Ye , Chen Li , Yang Xie , Wen Zhang , Hong-Yu Zhang , Bowen Wang , Debo Cheng , Zaiwen Feng

In Human-Robot Interaction (HRI) systems, a challenging task is sharing the representation of the operational environment, fusing symbolic knowledge and perceptions, between users and robots. With the existing HRI pipelines, users can teach…

Robotics · Computer Science 2023-01-18 E. Bartoli , F. Argenziano , V. Suriani , D. Nardi

Contextual word embedding models such as ELMo (Peters et al., 2018) and BERT (Devlin et al., 2018) have dramatically improved performance for many natural language processing (NLP) tasks in recent months. However, these models have been…

Computation and Language · Computer Science 2019-06-24 Emily Alsentzer , John R. Murphy , Willie Boag , Wei-Hung Weng , Di Jin , Tristan Naumann , Matthew B. A. McDermott

Language Models such as BERT have grown in popularity due to their ability to be pre-trained and perform robustly on a wide range of Natural Language Processing tasks. Often seen as an evolution over traditional word embedding techniques,…

Computation and Language · Computer Science 2022-06-30 Nimesh Bhana , Terence L. van Zyl

Supervised models trained to predict properties from representations have been achieving high accuracy on a variety of tasks. For instance, the BERT family seems to work exceptionally well on the downstream task from NER tagging to the…

Computation and Language · Computer Science 2020-12-22 Tejas Vaidhya , Ayush Kaushal

Predicting drug-gene associations is crucial for drug development and disease treatment. While graph neural networks (GNN) have shown effectiveness in this task, they face challenges with data sparsity and efficient contrastive learning…

Machine Learning · Computer Science 2025-02-14 Jiayang Wu , Wensheng Gan , Philip S. Yu

Word embeddings play a significant role in today's Natural Language Processing tasks and applications. While pre-trained models may be directly employed and integrated into existing pipelines, they are often fine-tuned to better fit with…

Computation and Language · Computer Science 2022-11-10 Denys Amore Bondarenko , Roger Ferrod , Luigi Di Caro

The role of Artificial Intelligence (AI) is growing in every stage of drug development. Nevertheless, a major challenge in drug discovery AI remains: Drug pharmacokinetic (PK) and Drug-Target Interaction (DTI) datasets collected in…

Quantitative Methods · Quantitative Biology 2025-10-27 Bing Hu , Jong-Hoon Park , Helen Chen , Young-Rae Cho , Anita Layton

Extensive adoption of electronic health records (EHRs) offers opportunities for their use in various downstream clinical analyses. To accomplish this purpose, enriching an EHR cohort with external knowledge (e.g., standardized medical…

Machine Learning · Computer Science 2024-06-13 Ahmad Wisnu Mulyadi , Heung-Il Suk

Electronic health records (EHR) contain narrative notes that provide extensive details on the medical condition and management of patients. Natural language processing (NLP) of clinical notes can use observed frequencies of clinical terms…

Computation and Language · Computer Science 2023-07-04 Bryan Cai , Sihang Zeng , Yucong Lin , Zheng Yuan , Doudou Zhou , Lu Tian

Drug-drug interaction (DDI) is a major cause of morbidity and mortality and a subject of intense scientific interest. Biomedical literature mining can aid DDI research by extracting evidence for large numbers of potential interactions from…

Machine Learning · Statistics 2015-05-19 Artemy Kolchinsky , Anália Lourenço , Heng-Yi Wu , Lang Li , Luis M. Rocha

Cross-domain NER is a practical yet challenging problem since the data scarcity in the real-world scenario. A common practice is first to learn a NER model in a rich-resource general domain and then adapt the model to specific domains. Due…

Computation and Language · Computer Science 2024-08-09 Junhao Zheng , Haibin Chen , Qianli Ma

Abstract. Cross-lingual knowledge alignment is the cornerstone in building a comprehensive knowledge graph (KG), which can benefit various knowledge-driven applications. As the structures of KGs are usually sparse, attributes of entities…

Computation and Language · Computer Science 2020-03-03 Bo Chen , Jing Zhang , Xiaobin Tang , Hong Chen , Cuiping Li

Ontology-based approaches for predicting gene-disease associations include the more classical semantic similarity methods and more recently knowledge graph embeddings. While semantic similarity is typically restricted to hierarchical…

Machine Learning · Computer Science 2021-06-01 Susana Nunes , Rita T. Sousa , Catia Pesquita

Most existing methods for predicting drug-drug interactions (DDI) predominantly concentrate on capturing the explicit relationships among drugs, overlooking the valuable implicit correlations present between drug pairs (DPs), which leads to…

Machine Learning · Computer Science 2024-02-29 Mengying Jiang , Guizhong Liu , Yuanchao Su , Weiqiang Jin , Biao Zhao

Simultaneous administration of multiple drugs can have synergistic or antagonistic effects as one drug can affect activities of other drugs. Synergistic effects lead to improved therapeutic outcomes, whereas, antagonistic effects can be…

Computation and Language · Computer Science 2017-08-15 Sunil Kumar Sahu , Ashish Anand

Pre-trained language models such as BERT have been a key ingredient to achieve state-of-the-art results on a variety of tasks in natural language processing and, more recently, also in information retrieval.Recent research even claims that…

Information Retrieval · Computer Science 2022-05-03 Emma J. Gerritse , Faegheh Hasibi , Arjen P. de Vries

Drug combination therapy is a well-established strategy for disease treatment with better effectiveness and less safety degradation. However, identifying novel drug combinations through wet-lab experiments is resource intensive due to the…

Machine Learning · Computer Science 2023-01-18 Zhihang Hu , Qinze Yu , Yucheng Guo , Taifeng Wang , Irwin King , Xin Gao , Le Song , Yu Li