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In healthcare, it is essential to explain the decision-making process of machine learning models to establish the trustworthiness of clinicians. This paper introduces BI-RADS-Net, a novel explainable deep learning approach for cancer…

Computer Vision and Pattern Recognition · Computer Science 2021-10-11 Boyu Zhang , Aleksandar Vakanski , Min Xian

We propose Medical Entity Definition-based Sentence Embedding (MED-SE), a novel unsupervised contrastive learning framework designed for clinical texts, which exploits the definitions of medical entities. To this end, we conduct an…

Machine Learning · Computer Science 2022-12-12 Hyeonbin Hwang , Haanju Yoo , Yera Choi

Deep generative models, while revolutionizing fields like image and text generation, largely operate as opaque ``black boxes'', hindering human understanding, control, and alignment. While methods like sparse autoencoders (SAEs) show…

Machine Learning · Computer Science 2026-04-03 Lingjing Kong , Shaoan Xie , Guangyi Chen , Yuewen Sun , Xiangchen Song , Eric P. Xing , Kun Zhang

Faced with distribution shift between training and test set, we wish to detect and quantify the shift, and to correct our classifiers without test set labels. Motivated by medical diagnosis, where diseases (targets) cause symptoms…

Machine Learning · Computer Science 2018-07-27 Zachary C. Lipton , Yu-Xiang Wang , Alex Smola

The rapid expansion of medical informatics literature presents significant challenges in synthesizing and analyzing research trends. This study introduces a novel dataset derived from the Medical Informatics Europe (MIE) Conference…

Information Retrieval · Computer Science 2024-10-08 Ehsan Bitaraf , Maryam Jafarpour

Sparse Autoencoders (SAEs) have been successfully used to probe Large Language Models (LLMs) and extract interpretable concepts from their internal representations. These concepts are linear combinations of neuron activations that…

Computation and Language · Computer Science 2026-02-23 Mathis Le Bail , Jérémie Dentan , Davide Buscaldi , Sonia Vanier

Most AI systems are black boxes generating reasonable outputs for given inputs. Some domains, however, have explainability and trustworthiness requirements that cannot be directly met by these approaches. Various methods have therefore been…

Artificial Intelligence · Computer Science 2024-10-28 Hormoz Shahrzad , Babak Hodjat , Risto Miikkulainen

We introduce EmoLIME, a version of local interpretable model-agnostic explanations (LIME) for black-box Speech Emotion Recognition (SER) models. To the best of our knowledge, this is the first attempt to apply LIME in SER. EmoLIME generates…

Sound · Computer Science 2025-04-09 Maja J. Hjuler , Line H. Clemmensen , Sneha Das

Constructing large-scaled medical knowledge graphs can significantly boost healthcare applications for medical surveillance, bring much attention from recent research. An essential step in constructing large-scale MKG is extracting…

Computer Vision and Pattern Recognition · Computer Science 2021-10-27 Jialun Wu , Yang Liu , Zeyu Gao , Tieliang Gong , Chunbao Wang , Chen Li

Existing tools for explaining the output of image classifiers can be divided into white-box, which rely on access to the model internals, and black-box, agnostic to the model. As the usage of AI in the medical domain grows, so too does the…

Computer Vision and Pattern Recognition · Computer Science 2023-11-27 Nathan Blake , Hana Chockler , David A. Kelly , Santiago Calderon Pena , Akchunya Chanchal

Reliable and interpretable decision-making is essential in medical imaging, where diagnostic outcomes directly influence patient care. Despite advances in deep learning, most medical AI systems operate as opaque black boxes, providing…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Pirzada Suhail , Aditya Anand , Amit Sethi

Deep learning enables the modelling of high-resolution histopathology whole-slide images (WSI). Weakly supervised learning of tile-level data is typically applied for tasks where labels only exist on the patient or WSI level (e.g. patient…

Image and Video Processing · Electrical Eng. & Systems 2025-06-09 Abhinav Sharma , Bojing Liu , Mattias Rantalainen

Optimization in the latent space of variational autoencoders is a promising approach to generate high-dimensional discrete objects that maximize an expensive black-box property (e.g., drug-likeness in molecular generation, function…

Machine Learning · Computer Science 2021-07-02 Pascal Notin , José Miguel Hernández-Lobato , Yarin Gal

Counterfactual explanations (CFE) for deep image classifiers aim to reveal how minimal input changes lead to different model decisions, providing critical insights for model interpretation and improvement. However, existing CFE methods…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Townim Faisal Chowdhury , Vu Minh Hieu Phan , Kewen Liao , Nanyu Dong , Minh-Son To , Anton Hengel , Johan Verjans , Zhibin Liao

Machine learning models have undeniably achieved impressive performance across a range of applications. However, their often perceived black-box nature, and lack of transparency in decision-making, have raised concerns about understanding…

Machine Learning · Computer Science 2023-10-03 Sein Minn

Decision trees are a popular machine learning method, known for their inherent explainability. In Explainable AI, decision trees can be used as surrogate models for complex black box AI models or as approximations of parts of such models. A…

Artificial Intelligence · Computer Science 2025-10-08 Ana Ozaki , Roberto Confalonieri , Ricardo Guimarães , Anders Imenes

Recent advancements in machine learning have spurred growing interests in automated interpreting quality assessment. Nevertheless, existing research suffers from insufficient examination of language use quality, unsatisfactory modeling…

Computation and Language · Computer Science 2025-08-15 Zhaokun Jiang , Ziyin Zhang

Pre-trained language models induce dense entity representations that offer strong performance on entity-centric NLP tasks, but such representations are not immediately interpretable. This can be a barrier to model uptake in important…

Computation and Language · Computer Science 2021-06-18 Diego Garcia-Olano , Yasumasa Onoe , Ioana Baldini , Joydeep Ghosh , Byron C. Wallace , Kush R. Varshney

This study examines the application of Bayesian approach in the context of clinical trials, emphasizing their increasing importance in contemporary biomedical research. While conventional frequentist approach provides a foundational basis…

Methodology · Statistics 2026-01-16 Paramahansa Pramanik , Arnab Kumar Maity , Anjan Mandal , Haley Kate Robinson

A diverse range of large language models (LLMs), e.g., ChatGPT, and visual question answering (VQA) models, e.g., BLIP, have been developed for solving textual and visual question answering tasks. However, fine-tuning these models is either…

Computation and Language · Computer Science 2024-12-18 Yuxi Xia , Kilm Zaporojets , Benjamin Roth