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Black-box Artificial Intelligence (AI) methods, e.g. deep neural networks, have been widely utilized to build predictive models that can extract complex relationships in a dataset and make predictions for new unseen data records. However,…

Artificial Intelligence · Computer Science 2020-09-22 Milad Moradi , Matthias Samwald

Deep neural networks and other intricate Artificial Intelligence (AI) models have reached high levels of accuracy on many biomedical natural language processing tasks. However, their applicability in real-world use cases may be limited due…

Artificial Intelligence · Computer Science 2020-10-22 Milad Moradi , Matthias Samwald

Effectively explaining decisions of black-box machine learning models is critical to responsible deployment of AI systems that rely on them. Recognizing their importance, the field of explainable AI (XAI) provides several techniques to…

Artificial Intelligence · Computer Science 2025-07-25 Yao Rong , Peizhu Qian , Vaibhav Unhelkar , Enkelejda Kasneci

We present an approach to explain the decisions of black box models for image classification. While using the black box to label images, our explanation method exploits the latent feature space learned through an adversarial autoencoder.…

Computer Vision and Pattern Recognition · Computer Science 2020-02-11 Riccardo Guidotti , Anna Monreale , Stan Matwin , Dino Pedreschi

As black box models and pretrained models gain traction in time series applications, understanding and explaining their predictions becomes increasingly vital, especially in high-stakes domains where interpretability and trust are…

Machine Learning · Computer Science 2026-01-16 Khalid Oublal , Quentin Bouniot , Qi Gan , Stephan Clémençon , Zeynep Akata

With the increasing use of large language models (LLMs) for generating answers to biomedical questions, it is crucial to evaluate the quality of the generated answers and the references provided to support the facts in the generated…

Computation and Language · Computer Science 2026-02-10 Deepak Gupta , Davis Bartels , Dina Demner-Fushman

While dense biomedical embeddings achieve strong performance, their black-box nature limits their utility in clinical decision-making. Recent question-based interpretable embeddings represent text as binary answers to natural-language…

Computation and Language · Computer Science 2026-03-04 Yixuan Tang , Zhenghong Lin , Yandong Sun , Wynne Hsu , Mong Li Lee , Anthony K. H. Tung

Question Answer (QA) systems for biomedical experiments facilitate cross-disciplinary communication, and serve as a foundation for downstream tasks, e.g., laboratory automation. High Information Density (HID) and Multi-Step Reasoning (MSR)…

Artificial Intelligence · Computer Science 2026-01-09 Haofei Hou , Shunyi Zhao , Fanxu Meng , Kairui Yang , Lecheng Ruan , Qining Wang

This paper addresses the challenge of generating Counterfactual Explanations (CEs), involving the identification and modification of the fewest necessary features to alter a classifier's prediction for a given image. Our proposed method,…

Computer Vision and Pattern Recognition · Computer Science 2023-11-16 Guillaume Jeanneret , Loïc Simon , Frédéric Jurie

Multimodal classifiers function as opaque black box models. While several techniques exist to interpret their predictions, very few of them are as intuitive and accessible as natural language explanations (NLEs). To build trust, such…

Computation and Language · Computer Science 2025-12-09 Dibyanayan Bandyopadhyay , Soham Bhattacharjee , Mohammed Hasanuzzaman , Asif Ekbal

Biomedical information extraction (BioIE) is important to many applications, including clinical decision support, integrative biology, and pharmacovigilance, and therefore it has been an active research. Unlike existing reviews covering a…

Computation and Language · Computer Science 2016-06-28 Feifan Liu , Jinying Chen , Abhyuday Jagannatha , Hong Yu

The application of deep learning in medical imaging has significantly advanced diagnostic capabilities, enhancing both accuracy and efficiency. Despite these benefits, the lack of transparency in these AI models, often termed "black boxes,"…

Computer Vision and Pattern Recognition · Computer Science 2024-09-23 Eleonora Beatrice Rossi , Eleonora Lopez , Danilo Comminiello

Recent developments in Artificial Intelligence (AI) and their applications in critical industries such as healthcare, fin-tech and cybersecurity have led to a surge in research in explainability in AI. Innovative research methods are being…

Artificial Intelligence · Computer Science 2025-08-26 Aoun E Muhammad , Kin-Choong Yow , Nebojsa Bacanin-Dzakula , Muhammad Attique Khan

The lack of explainability is one of the most prominent disadvantages of deep learning applications in omics. This "black box" problem can undermine the credibility and limit the practical implementation of biomedical deep learning models.…

Genomics · Quantitative Biology 2021-08-19 Eloise Withnell , Xiaoyu Zhang , Kai Sun , Yike Guo

Interpreting machine learning models remains a challenge, hindering their adoption in clinical settings. This paper proposes leveraging Local Interpretable Model-Agnostic Explanations (LIME) to provide interpretable descriptions of black…

Machine Learning · Computer Science 2023-06-23 Mozhgan Salimiparsa , Surajsinh Parmar , San Lee , Choongmin Kim , Yonghwan Kim , Jang Yong Kim

Despite outstanding contribution to the significant progress of Artificial Intelligence (AI), deep learning models remain mostly black boxes, which are extremely weak in explainability of the reasoning process and prediction results.…

Machine Learning · Computer Science 2020-02-11 Sheng Shi , Xinfeng Zhang , Wei Fan

Automatic identification and expansion of ambiguous abbreviations are essential for biomedical natural language processing applications, such as information retrieval and question answering systems. In this paper, we present DEep…

Computation and Language · Computer Science 2019-06-11 Qiao Jin , Jinling Liu , Xinghua Lu

The recent surge of foundation models in computer vision and natural language processing opens up perspectives in utilizing multi-modal clinical data to train large models with strong generalizability. Yet pathological image datasets often…

Computer Vision and Pattern Recognition · Computer Science 2023-07-28 Yunkun Zhang , Jin Gao , Mu Zhou , Xiaosong Wang , Yu Qiao , Shaoting Zhang , Dequan Wang

Information Extraction (IE) from text refers to the task of extracting structured knowledge from unstructured text. The task typically consists of a series of sub-tasks such as Named Entity Recognition and Relation Extraction. Sourcing…

Computation and Language · Computer Science 2022-04-12 Yannis Papanikolaou , Marlene Staib , Justin Grace , Francine Bennett

The field of Explainable Artificial Intelligence (XAI) aims to improve the interpretability of black-box machine learning models. Building a heatmap based on the importance value of input features is a popular method for explaining the…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Amirhossein Aminimehr , Pouya Khani , Amirali Molaei , Amirmohammad Kazemeini , Erik Cambria
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