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We study the global dynamics of a reaction-diffusion SEIR infection model with distributed delay and nonlinear incidence rate. The well-posedness of the proposed model is proved. By means of Lyapunov functionals, we show that the disease…

Populations and Evolution · Quantitative Biology 2022-04-21 Abdesslem Lamrani Alaoui , Moulay Rchid Sidi Ammi , Mouhcine Tilioua , Delfim F. M. Torres

In this article, we discuss an age-structured SIR model in which disease not only spread through direct person to person contacts for e.g. infection due to surface contamination but it can also spread through indirect contacts. It is…

Populations and Evolution · Quantitative Biology 2020-07-24 Manoj Kumar , Syed Abbas

We present a modified age-structured SIR model based on known patterns of social contact and distancing measures within Washington, USA. We find that population age-distribution has a significant effect on disease spread and mortality rate,…

Populations and Evolution · Quantitative Biology 2022-10-18 Vishaal Ram , Laura P. Schaposnik

The Susceptible-Infected-Susceptible (SIS) model is a widely used model for the spread of information and infectious diseases, particularly non-immunizing ones, on a graph. Given a highly contagious disease, a natural question is how to…

Machine Learning · Computer Science 2025-06-19 Sepehr Elahi , Paula Mürmann , Patrick Thiran

The vaccination against ongoing epidemics is seldom compulsory but remains one of the most classical means to fight epidemic propagation. However recent debates concerning the innocuity of vaccines and their risk with respect to the risk of…

Populations and Evolution · Quantitative Biology 2024-10-07 Laetitia Laguzet , Gabriel Turinici

There are often multiple diseases with cross immunity competing for vaccination resources. Here we investigate the optimal vaccination program in a two-layer Susceptible-Infected-Removed (SIR) model, where two diseases with cross immunity…

Populations and Evolution · Quantitative Biology 2021-05-26 Yang Ye , Qingpeng Zhang , Zhidong Cao , Daniel Dajun Zeng

This paper utilizes a stochastic Susceptible-Infected-recovered (SIR) model with a non-linear incidence rate to perform a detailed mathematical study of optimal lock-down intensity and vaccination rate under the COVID-19 pandemic…

Optimization and Control · Mathematics 2022-09-29 Paramahansa Pramanik

In this paper we investigate the asymptotic behavior of some SIR models incorporating demography, bounded random transmission coefficient and a time-dependent vaccination strategy targeting the susceptible population. In this setting, we…

Populations and Evolution · Quantitative Biology 2025-10-27 Javier López-de-la-Cruz , Susana Merchán , Felipe Rivero , Javier Rodrigo

An age-structured Susceptible-Infected-Recovered-Deceased (SIRD) epidemic model is considered. The aim of this paper is to design an observer-based output feedback control law, representing an immunization process, typically vaccination,…

Optimization and Control · Mathematics 2024-10-28 Candy Sonveaux , Christophe Prieur , Gildas Besançon , Joseph J. Winkin

Understanding the dynamics of an epidemic spread is crucial for effective control measures. During the COVID-19 pandemic, quarantines were implemented to minimize infections while mitigating social and economic impacts, raising the question…

Statistical Mechanics · Physics 2024-11-19 Eyal Atias , Michael Assaf

In this study initially, we propose an age structured model and calculate the equilibrium points and basic reproduction number. Later we propose an optimal control problem to understand the roles of treatment in controlling the epidemic.…

Dynamical Systems · Mathematics 2020-12-15 Bishal Chhetri , D. K. K Vamsi , Carani B Sanjeevi

We study three different strategies of vaccination in a SEIRS (Susceptible--Exposed--Infected--Recovered--Susceptible) seasonal forced model, which are: ($i$) continuous vaccination; ($ii$) periodic short time localized vaccination and…

The focus of this article is on the dynamics of a new susceptible-infected model which consists of a susceptible group ($S$) and two different infectious groups ($I_1$ and $I_2$). Once infected, an individual becomes a member of one of…

Populations and Evolution · Quantitative Biology 2020-06-01 Ayse Peker-Dobie , Semra Ahmetolan , Ayse Humeyra Bilge , Ali Demirci

In this paper we introduce an approach to the management of infectious disease diffusion through the formulation of a controlled compartmental SVIR (Susceptible-Vaccinated-Infected-Recovered) model. We consider a cost functional…

Optimization and Control · Mathematics 2023-11-28 Alessandro Ramponiand M. Elisabetta Tessitore

We consider a behavioral-feedback SIR epidemic model, in which the infection rate depends in feedback on the fractions of susceptible and infected agents, respectively. The considered model allows one to account for endogenous adaptation…

Systems and Control · Electrical Eng. & Systems 2026-02-11 Martina Alutto , Leonardo Cianfanelli , Giacomo Como , Fabio Fagnani , Francesca Parise

We study an optimal control problem for a non-autonomous SEIRS model with incidence given by a general function of the infective, the susceptible and the total population, and with vaccination and treatment as control variables. We prove…

Optimization and Control · Mathematics 2018-06-13 Joaquim P. Mateus , Paulo Rebelo , Silvério Rosa , César M. Silva , Delfim F. M. Torres

We develop a mechanistic model that classifies individuals both in terms of epidemiological status (SIR) and vaccination attitude (willing or unwilling), with the goal of discovering how disease spread is influenced by changing opinions…

Dynamical Systems · Mathematics 2024-08-16 Yi Jiang , Kristin M. Kurianski , Jane HyoJin Lee , Yanping Ma , Daniel Cicala , Glenn Ledder

We analyze infection spreading processes in a system where only a fraction $p$ of individuals can be affected by disease, while remaining $1-p$ individuals are immune. Such a picture can emerge as a natural consequence of previously…

Disordered Systems and Neural Networks · Physics 2021-12-06 V. Blavatska , Yu. Holovatch

We examine the age-structured SIR model, a variant of the classical Susceptible-Infected-Recovered (SIR) model of epidemic propagation, in the context of COVID-19. In doing so, we provide a theoretical basis for the model, perform an…

Optimization and Control · Mathematics 2022-03-11 Rohit Parasnis , Ryosuke Kato , Amol Sakhale , Massimo Franceschetti , Behrouz Touri

Since COVID-19 vaccines became available, no studies have quantified how different disaster evacuation strategies can mitigate pandemic risks in shelters. Therefore, we applied an age-structured epidemiological model, known as the…

Populations and Evolution · Quantitative Biology 2022-08-30 Yi-Lin Tsai , Dymasius Y. Sitepu , Karyn E. Chappell , Rishi P. Mediratta , C. Jason Wang , Peter K. Kitanidis , Christopher B. Field