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Chemical reaction systems are dynamical systems that arise in chemical engineering and systems biology. In this work, we consider the question of whether the minimal (in a precise sense) multistationary chemical reaction networks, which we…

Dynamical Systems · Mathematics 2012-07-10 Badal Joshi , Anne Shiu

In this paper, the question how spiking neural network (SNN) learns and fixes in its internal structures a model of external world dynamics is explored. This question is important for implementation of the model-based reinforcement learning…

Neural and Evolutionary Computing · Computer Science 2022-09-21 Mikhail Kiselev

We establish a new relationship between monotonicity and contractivity and use this connection to describe a new general class of weakly contractive reaction networks. The new class is characterized by the stoichiometry matrix of the…

Dynamical Systems · Mathematics 2025-06-24 Alon Duvall , M. Ali Al-Radhawi , Dhruv D. Jatkar , Eduardo Sontag

Zero-one reaction networks are pivotal to cellular signaling, and establishing the equivalence of such networks represents a foundational computational challenge in the realm of chemical reaction network research. Herein, we propose a…

Molecular Networks · Quantitative Biology 2026-02-03 Yue Jiao , Xiaoxian Tang

A class of chemical reaction networks is described with the property that each positive equilibrium is locally asymptotically stable relative to its stoichiometry class, an invariant subspace on which it lies. The reaction systems treated…

Dynamical Systems · Mathematics 2013-04-11 Pete Donnell , Murad Banaji

We identify the thermodynamic conditions necessary to observe indefinite growth in homogeneous open chemical reaction networks (CRNs) satisfying mass action kinetics. We also characterize the thermodynamic efficiency of growth by…

Molecular Networks · Quantitative Biology 2024-12-05 Shesha Gopal Marehalli Srinivas , Francesco Avanzini , Massimiliano Esposito

A stochastic model for a chemical reaction network is embedded in a one-parameter family of models with species numbers and rate constants scaled by powers of the parameter. A systematic approach is developed for determining appropriate…

Probability · Mathematics 2010-11-09 Hye-Won Kang , Thomas G. Kurtz

Recurrent stochastic configuration networks (RSCNs) are a class of randomized learner models that have shown promise in modelling nonlinear dynamics. In many fields, however, the data generated by industry systems often exhibits…

Machine Learning · Computer Science 2024-10-15 Gang Dang , Dianhui Wang

Complex networks, comprised of individual elements that interact with each other through reaction channels, are ubiquitous across many scientific and engineering disciplines. Examples include biochemical, pharmacokinetic, epidemiological,…

Mathematical Physics · Physics 2013-06-14 John Goutsias , Garrett Jenkinson

We show that adding new chemical species into the reactions of a chemical reaction network (CRN) in such a way that the rank of the network remains unchanged preserves its capacity for multiple nondegenerate equilibria and/or periodic…

Dynamical Systems · Mathematics 2022-09-14 Murad Banaji , Balázs Boros , Josef Hofbauer

It has recently been shown that structural conditions on the reaction network, rather than a 'fine-tuning' of system parameters, often suffice to impart 'absolute concentration robustness' on a wide class of biologically relevant,…

Probability · Mathematics 2014-01-20 David F. Anderson , German Enciso , Matthew Johnston

We describe a large class of chemical reaction networks, those endowed with a subtle structural property called concordance. We show that the class of concordant networks coincides precisely with the class of networks which, when taken with…

Molecular Networks · Quantitative Biology 2011-09-15 Guy Shinar , Martin Feinberg

We examine the dynamical properties of a single-layer convolutional recurrent network with a smooth sigmoidal activation function, for small values of the inputs and when the convolution kernel is unitary, so all eigenvalues lie exactly at…

Statistical Mechanics · Physics 2024-05-24 Aditi Chandra , Marcelo O. Magnasco

Chemical reaction networks (CRNs) are foundational models for describing complex biochemical processes. We study noncompetitive CRNs, a class of networks whose static states are rate-independent, and that can implement ReLU neural networks.…

Molecular Networks · Quantitative Biology 2025-12-22 Louis Faul , Xavier Richard , Mary Betrisey , Christian Mazza

Chemical reaction networks (CRNs) are fundamental computational models used to study the behavior of chemical reactions in well-mixed solutions. They have been used extensively to model a broad range of biological systems, and are primarily…

Molecular Networks · Quantitative Biology 2021-05-13 J. N. Mueller , J. N. Corcoran

In chemical reaction networks (CRNs) with stochastic semantics based on continuous-time Markov chains (CTMCs), the typically large populations of species cause combinatorially large state spaces. This makes the analysis very difficult in…

Logic in Computer Science · Computer Science 2017-07-10 Luca Cardelli , Mirco Tribastone , Max Tschaikowski , Andrea Vandin

The thermodynamic and dynamical conditions necessary to observe indefinite growth in homogeneous open chemical reaction networks (CRNs) satisfying mass action kinetics were presented in Srinivas et al. (2023): Unimolecular CRNs can only…

Molecular Networks · Quantitative Biology 2024-12-05 Shesha Gopal Marehalli Srinivas , Francesco Avanzini , Massimiliano Esposito

While the analytical solution for the marginal distribution of a stochastic chemical reaction network has been extensively studied, its joint distribution, i.e. the solution of a high-dimensional chemical master equation, has received much…

Molecular Networks · Quantitative Biology 2021-11-16 Youming Li , Da-Quan Jiang , Chen Jia

Combinatorial threshold-linear networks (CTLNs) are a special class of recurrent neural networks whose dynamics are tightly controlled by an underlying directed graph. Recurrent networks have long been used as models for associative memory…

Neurons and Cognition · Quantitative Biology 2023-11-21 Carina Curto , Jesse Geneson , Katherine Morrison

Detailed balance of a chemical reaction network can be defined in several different ways. Here we investigate the relationship among four types of detailed balance conditions: deterministic, stochastic, local, and zero-order local detailed…

Probability · Mathematics 2021-01-27 Chen Jia , Da-Quan Jiang , Youming Li
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