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The use of mathematical methods for the analysis of chemical reaction systems has a very long history, and involves many types of models: deterministic versus stochastic, continuous versus discrete, and homogeneous versus spatially…

Molecular Networks · Quantitative Biology 2018-05-29 Polly Y. Yu , Gheorghe Craciun

In this work, we propose CLass-Enhanced Attentive Response (CLEAR): an approach to visualize and understand the decisions made by deep neural networks (DNNs) given a specific input. CLEAR facilitates the visualization of attentive regions…

Computer Vision and Pattern Recognition · Computer Science 2017-05-22 Devinder Kumar , Alexander Wong , Graham W. Taylor

Interpreting neural networks is a crucial and challenging task in machine learning. In this paper, we develop a novel framework for detecting statistical interactions captured by a feedforward multilayer neural network by directly…

Machine Learning · Statistics 2018-02-28 Michael Tsang , Dehua Cheng , Yan Liu

Real world learning scenarios involve a nonstationary distribution of classes with sequential dependencies among the samples, in contrast to the standard machine learning formulation of drawing samples independently from a fixed, typically…

Computer Vision and Pattern Recognition · Computer Science 2022-05-31 Mengye Ren , Tyler R. Scott , Michael L. Iuzzolino , Michael C. Mozer , Richard Zemel

Chemical reaction networks (CRNs) formally model chemistry in a well-mixed solution. CRNs are widely used to describe information processing occurring in natural cellular regulatory networks, and with upcoming advances in synthetic biology,…

Computational Complexity · Computer Science 2013-04-17 David Doty

State-of-the-art deep neural network recognition systems are designed for a static and closed world. It is usually assumed that the distribution at test time will be the same as the distribution during training. As a result, classifiers are…

Computer Vision and Pattern Recognition · Computer Science 2019-02-28 Benjamin J. Meyer , Tom Drummond

In this paper, we propose a new method to identify biochemical reaction networks (i.e. both reactions and kinetic parameters) from heterogeneous datasets. Such datasets can contain (a) data from several replicates of an experiment performed…

Systems and Control · Computer Science 2015-09-21 Wei Pan , Ye Yuan , Lennart Ljung , Jorge Goncalves , Guy-Bart Stan

Chemical reaction network is an important method for modeling and exploring complex biological processes, bio-chemical interactions and the behavior of different dynamics in system biology. But, formulating such reaction kinetics takes…

Artificial Intelligence · Computer Science 2025-03-28 Sadikshya Gyawali , Ashwini Mandal , Manish Dahal , Manish Awale , Sanjay Rijal , Shital Adhikari , Vaghawan Ojha

In recent years, self-supervised learning has emerged as a powerful tool to harness abundant unlabelled data for representation learning and has been broadly adopted in diverse areas. However, when applied to molecular representation…

Machine Learning · Computer Science 2024-02-22 Han Tang , Shikun Feng , Bicheng Lin , Yuyan Ni , JIngjing Liu , Wei-Ying Ma , Yanyan Lan

While the field of first-principles explorations into chemical reaction space has been continuously growing, the development of strategies for analyzing resulting chemical reaction networks (CRNs) is lagging behind. A CRN consists of…

Chemical Physics · Physics 2022-12-19 Paul L. Türtscher , Markus Reiher

Accurately predicting chemical reactions is essential for driving innovation in synthetic chemistry, with broad applications in medicine, manufacturing, and agriculture. At the same time, reaction prediction is a complex problem which can…

Machine Learning · Computer Science 2025-04-23 Ryan J. Miller , Alexander E. Dashuta , Brayden Rudisill , David Van Vranken , Pierre Baldi

Many nonequilibrium systems, such as biochemical reactions and socioeconomic interactions, can be described by reaction-diffusion equations that demonstrate a wide variety of complex spatiotemporal patterns. The diversity of the morphology…

Computational Physics · Physics 2022-02-02 Christian Scholz , Sandy Scholz

In drug-discovery-related tasks such as virtual screening, machine learning is emerging as a promising way to predict molecular properties. Conventionally, molecular fingerprints (numerical representations of molecules) are calculated…

Machine Learning · Computer Science 2019-11-13 Shion Honda , Shoi Shi , Hiroki R. Ueda

Chemical reaction prediction remains a fundamental challenge in organic chemistry, where existing machine learning models face two critical limitations: sensitivity to input permutations (molecule/atom orderings) and inadequate modeling of…

Machine Learning · Computer Science 2026-02-03 Runhan Shi , Letian Chen , Gufeng Yu , Yang Yang

Chemical Reaction Neural Networks (CRNNs) have emerged as an interpretable machine learning framework for discovering reaction kinetics directly from data, while strictly adhering to the Arrhenius and mass action laws. However, standard…

Chemical Physics · Physics 2026-05-15 Benjamin C. Koenig , Sili Deng

We present a technique for translating a black-box machine-learned classifier operating on a high-dimensional input space into a small set of human-interpretable observables that can be combined to make the same classification decisions. We…

High Energy Physics - Phenomenology · Physics 2021-04-21 Taylor Faucett , Jesse Thaler , Daniel Whiteson

Identifying objects in an image and their mutual relationships as a scene graph leads to a deep understanding of image content. Despite the recent advancement in deep learning, the detection and labeling of visual object relationships…

Computer Vision and Pattern Recognition · Computer Science 2021-07-13 Rajat Koner , Poulami Sinhamahapatra , Volker Tresp

Theoretical studies on chemical reaction mechanisms have been crucial in organic chemistry. Traditionally, calculating the manually constructed molecular conformations of transition states for chemical reactions using quantum chemical…

Chemical Physics · Physics 2024-04-12 Sihao Yuan , Xu Han , Jun Zhang , Zhaoxin Xie , Cheng Fan , Yunlong Xiao , Yi Qin Gao , Yi Isaac Yang

We provide a category theoretical framework capturing two approaches to graph-based models of chemistry: formal reactions and disconnection rules. We model a translation from the latter to the former as a functor, which is faithful, and…

Logic in Computer Science · Computer Science 2024-10-03 Ella Gale , Leo Lobski , Fabio Zanasi

The demand for accurate food quantification has increased in the recent years, driven by the needs of applications in dietary monitoring. At the same time, computer vision approaches have exhibited great potential in automating tasks within…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Valasia Vlachopoulou , Ioannis Sarafis , Alexandros Papadopoulos
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