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The existence of doublets is a key confounder in single-cell RNA sequencing (scRNA-seq) data analysis. Computational methods have been developed for detecting doublets from scRNA-seq data. We developed an R package DoubletCollection to…

Genomics · Quantitative Biology 2021-12-01 Nan Miles Xi , Jingyi Jessica Li

LLMs are increasingly used as seq2seq translators from natural language utterances to structured programs, a process called semantic interpretation. Unlike atomic labels or token sequences, programs are naturally represented as abstract…

Computation and Language · Computer Science 2025-04-07 Mayank Kothyari , Sunita Sarawagi , Soumen Chakrabarti , Gaurav Arora , Srujana Merugu

LLM serving platforms are increasingly deployed as multi-model cloud systems, where user demand is often long-tailed: a few popular large models receive most requests, while many smaller tail models remain underutilized. We propose…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-13 Jincheng Xie , Yawen Ling , Qi Xiao , Feiyu Zhang , Zhongyi Huang , Wen Hu , Yu Zheng

Comparative transcriptomics has gained increasing popularity in genomic research thanks to the development of high-throughput technologies including microarray and next-generation RNA sequencing that have generated numerous transcriptomic…

Quantitative Methods · Quantitative Biology 2021-12-01 Wei Vivian Li , Yiling Chen , Jingyi Jessica Li

We present a new approach for the analysis of genome-wide expression data. Our method is designed to overcome the limitations of traditional techniques, when applied to large-scale data. Rather than alloting each gene to a single cluster,…

Biological Physics · Physics 2009-11-07 Sven Bergmann , Jan Ihmels , Naama Barkai

Keyphrase extraction (KPE) is an important task in Natural Language Processing for many scenarios, which aims to extract keyphrases that are present in a given document. Many existing supervised methods treat KPE as sequential labeling,…

Computation and Language · Computer Science 2024-03-21 Yuanzhen Luo , Qingyu Zhou , Feng Zhou

We present the architecture and the evaluation of a new system for recognizing textual entailment (RTE). In RTE we want to identify automatically the type of a logical relation between two input texts. In particular, we are interested in…

Computation and Language · Computer Science 2013-10-21 Andreas Wotzlaw , Ravi Coote

Medical treatments often involve a sequence of decisions, each informed by previous outcomes. This process closely aligns with reinforcement learning (RL), a framework for optimizing sequential decisions to maximize cumulative rewards under…

Machine Learning · Computer Science 2024-10-15 Ali Shirali , Alexander Schubert , Ahmed Alaa

Extracting MITRE ATT&CK techniques from cyber threat intelligence (CTI) reports is an open-set, multi-label problem requiring both high recall (not missing techniques) and high precision (not hallucinating unsupported ones). Existing…

Cryptography and Security · Computer Science 2026-05-26 Yutong Cheng , Changze Li , Raihan Sultan Pasha Basuki , Qian Cui , Wei Ding , Peng Gao

Large language models (LLMs) have exhibited remarkable few-shot learning capabilities and unified the paradigm of NLP tasks through the in-context learning (ICL) technique. Despite the success of ICL, the quality of the exemplar…

Computation and Language · Computer Science 2024-12-13 Yukang Lin , Bingchen Zhong , Shuoran Jiang , Joanna Siebert , Qingcai Chen

Even though in recent years the scale of statistical analysis problems has increased tremendously, many statistical software tools are still limited to single-node computations. However, statistical analyses are largely based on dense…

Computation · Statistics 2016-11-01 Rodrigo Canales , Elmar Peise , Paolo Bientinesi

RNA-Seq is a widely-used method for studying the behavior of genes under different biological conditions. An essential step in an RNA-Seq study is normalization, in which raw data are adjusted to account for factors that prevent direct…

Genomics · Quantitative Biology 2016-09-06 Ciaran Evans , Johanna Hardin , Daniel Stoebel

The sample selection approach is very popular in learning with noisy labels. As deep networks learn pattern first, prior methods built on sample selection share a similar training procedure: the small-loss examples can be regarded as clean…

Machine Learning · Computer Science 2023-09-06 Xiaobo Xia , Pengqian Lu , Chen Gong , Bo Han , Jun Yu , Jun Yu , Tongliang Liu

Relation extraction is an important task in structuring content of text data, and becomes especially challenging when learning with weak supervision---where only a limited number of labeled sentences are given and a large number of…

Computation and Language · Computer Science 2019-02-26 Hongtao Lin , Jun Yan , Meng Qu , Xiang Ren

A large volume of XML data is produced in experiments carried out by robots in laboratories. In order to support the interoperability of data between labs, there is a motivation to translate the XML data into a knowledge graph. A key stage…

Modern sequential recommender systems, ranging from lightweight transformer-based variants to large language models, have become increasingly prominent in academia and industry due to their strong performance in the next-item prediction…

Information Retrieval · Computer Science 2025-08-11 Danil Gusak , Anna Volodkevich , Anton Klenitskiy , Alexey Vasilev , Evgeny Frolov

Leakage contracts have recently been proposed as a new security abstraction at the Instruction Set Architecture (ISA) level. Such contracts aim to faithfully capture the information processors may leak through side effects of their…

Cryptography and Security · Computer Science 2023-09-29 Zilong Wang , Gideon Mohr , Klaus von Gleissenthall , Jan Reineke , Marco Guarnieri

Background: Single-cell RNA sequencing (scRNA-seq) enables gene expression profiling at cellular resolution but is inherently affected by sparsity caused by dropout events, where expressed genes are recorded as zeros due to technical…

Genomics · Quantitative Biology 2026-04-15 Yuichiro Iwashita , Ahtisham Fazeel Abbasi , Koichi Kise , Andreas Dengel , Muhammad Nabeel Asim

Next generation sequencing allows the identification of genes consisting of differentially expressed transcripts, a term which usually refers to changes in the overall expression level. A specific type of differential expression is…

Genomics · Quantitative Biology 2017-11-07 Panagiotis Papastamoulis , Magnus Rattray

Offline reinforcement learning aims to utilize datasets of previously gathered environment-action interaction records to learn a policy without access to the real environment. Recent work has shown that offline reinforcement learning can be…

Machine Learning · Computer Science 2023-08-30 Hanhan Zhou , Tian Lan , Vaneet Aggarwal