Related papers: Pump efficacy in a fluid-structure interaction mod…
Using essentially our 2011 numerical model of a multi-lymphangion segment of a collecting lymphatic vessel, but augmented by inclusion of a refractory period and definition of a mid lymphangion pressure, we explore the effect of several…
We present a unified mathematical framework for modeling blood and lymph flow in biological vessels, with a particular focus on lymph transport through lymphangions. Starting from first principles, we rigorously derive a system of partial…
We propose a one-dimensional model for collecting lymphatics coupled with a novel Electro-Fluid-Mechanical Contraction (EFMC) model for dynamical contractions, based on a modified FitzHugh-Nagumo model for action potentials. The…
Valveless pumping assists in fluid transport in various organisms and engineering systems. In a previous work, to study the actuator impact effects on valveless pumping, we constructed a piecewise-linear lumped-parameter model for a…
Peristalsis is the driving mechanism behind a broad array of biological and engineered flows. In peristaltic pumping, a wave-like contraction of the tube wall produces local changes in volume which induce flow. Net flow arises due to…
We explore an embryonic heart model that couples electrophysiology and muscle-force generation to flow induced using a $2D$ fluid-structure interaction framework based on the immersed boundary method. The propagation of action potentials…
Lymphedema, a disfiguring condition characterized by the asymmetrical swelling of the limbs, is suspected to be caused by dysfunctions in the lymphatic system. Lymphangions, the spontaneously contracting units of the lymphatic system, are…
Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering,…
Locally broken symmetries are used across fields to transport matter, particles and information in preferential directions. Beyond local mechanisms, spatially distributed nonlinearities in crystalline media have enabled non-reciprocal…
Coronary Microvascular Dysfunction (CMD) is characterized by impaired vasodilation and can lead to insufficient blood flow to the myocardium during stress or exertion, affecting millions of people globally. Despite their diagnostic value,…
In biological transport mechanisms such as insect respiration and renal filtration, fluid travels along a leaky channel allowing exchange with systems exterior the the channel. The channels in these systems may undergo peristaltic pumping…
Using both dynamical density functional theory and particle-resolved Brownian dynamics simulations, we explore the flow of two-dimensional colloidal solids and fluids driven through a linear channel with a geometric constriction. The flow…
The analysis and design of advection-diffusion based molecular communication (MC) systems in cylindrical environments is of particular interest for applications such as micro-fluidics and targeted drug delivery in blood vessels. Therefore,…
Flowing blood displays a phenomenon called margination, in which leukocytes and platelets are preferentially found near blood vessel walls, while erythrocytes are depleted from these regions. Here margination is investigated using direct…
Immersed nonlinear elements are prevalent in biological systems that require a preferential flow direction, such as the venous and the lymphatic system. We investigate here a certain class of models where the fluid is driven by peristaltic…
The present research is devoted to the problem of stability of the fluid flow moving in a channel with flexible walls and interacting with the walls, which are subject to traveling waves. Experimental data shows that the energy of the…
We use a theoretical model to explore how fluid dynamics, in particular, the pressure gradient and wall shear stress in a channel, affect the deposition of particles flowing in a microfluidic network. Experiments on transport of colloidal…
Computational fluid dynamics (CFD) is increasingly used to study blood flows in patient-specific arteries for understanding certain cardiovascular diseases. The techniques work quite well for relatively simple problems, but need…
Flows over remarkably long distances are crucial to the functioning of many organisms, across all kingdoms of life. Coordinated flows are fundamental to power deformations, required for migration or development, or to spread resources and…
Using a partonic transport model based on the 3-flavor Nambu-Jona-Lasinio model and a relativistic hadronic transport model to describe, respectively, the evolution of the initial partonic and the final hadronic phase of heavy-ion…