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Focusing light inside scattering media in a freely addressable fashion is challenging, as the wavefront of the scattered light is highly disordered. Recently developed ultrasound-guided wavefront shaping methods are addressing this…

Optics · Physics 2016-01-20 Haowen Ruan , Mooseok Jang , Changhuei Yang

Focusing light into opaque random or scattering media such as biological tissue is a much sought-after goal for biomedical applications such as photodynamic therapy, optical manipulation, and photostimulation. However, focusing with…

Optics · Physics 2014-03-10 Jian Wei Tay , Puxiang Lai , Yuta Suzuki , Lihong V. Wang

Manipulating and focusing light deep inside biological tissue and tissue-like complex media has been desired for long yet considered challenging. One feasible strategy is through optical wavefront engineering, where the optical…

Light scattering inhibits high-resolution optical imaging, manipulation and therapy deep inside biological tissue by preventing focusing. To form deep foci, wavefront-shaping and time-reversal techniques that break the optical diffusion…

Optics · Physics 2015-06-04 Cheng Ma , Fengbo Zhou , Yan Liu , Lihong V. Wang

Time reversal (TR) focusing of ultrasound in granular packings is experimentally investigated. Pulsed elastic waves transmitted from a compressional or shear transducer source are measured by a TR mirror, reversed in time and…

Soft Condensed Matter · Physics 2019-12-18 Maxime Harazi , Yougu Yang , Mathias Fink , Arnaud Tourin , Xiaoping Jia

The ability to steer light propagation inside scattering media has long been sought-after due to its potential widespread applications. To form optical foci inside scattering media, the only feasible strategy is to guide photons by using…

Optics · Physics 2014-04-30 Cheng Ma , Xiao Xu , Yan Liu , Lihong V. Wang

Over the past decade, optical wavefront shaping has been developed to focus light through highly opaque scattering layers, opening new possibilities for biomedical applications. To probe light intensity deep inside soft scattering media…

Optics · Physics 2025-08-25 Fei Xia , Ivo Leite , Robert Prevedel , Thomas Chaigne

Optical time-reversal techniques are being actively developed to focus light through or inside opaque scattering media. When applied to biological tissue, these techniques promise to revolutionize biophotonics by enabling deep-tissue…

Biological Physics · Physics 2016-11-07 Yuecheng Shen , Yan Liu , Cheng Ma , Lihong V. Wang

Biomedical applications requiring tissue diagnosis, activation, and treatment could be substantially leveraged by optical methods, owing to their unique feature set. However, their widespread application is severely limited by the strong…

Optics · Physics 2019-10-23 Maxim Cherkashin , Carsten Brenner , Georg Schmitz , Martin Hofmann

Deep, high-resolution imaging is essential for unraveling biological complexity and advancing medical diagnostics, yet scattering fundamentally limits optical methods. Among the most promising approaches, photoacoustic imaging achieves…

We consider the inverse source problem arising in thermo- and photo-acoustic tomography. It consists in reconstructing the initial pressure from the boundary measurements of the acoustic wave. Our goal is to extend versatile time reversal…

Analysis of PDEs · Mathematics 2015-11-13 Linh V. Nguyen , Leonid Kunyansky

Optical wavefront-shaping has emerged as a powerful tool to manipulate light in strongly scattering media. It enables diffraction-limited focusing and imaging at depths where conventional microscopy techniques fail. However, while most…

Optics · Physics 2014-03-04 T. Chaigne , O. Katz , A. C. Boccara , M. Fink , E. Bossy , S. Gigan

In this article, we consider the inverse source problem arising in photoacoustic tomography in elastic media. We show that the time reversal method, proposed by Tittelfitz [Inverse Problems 28.5 (2012): 055004], converges with the sharp…

Analysis of PDEs · Mathematics 2017-07-20 Vitaly Katsnelson , Linh V. Nguyen

Structured optical waveforms are emerging as powerful control fields for the next generation of complex photonic and electromagnetic systems, where the temporal structure of light can determine the ultimate performance of scientific…

Deep-tissue optical imaging suffers from the reduction of resolving power due to tissue-induced optical aberrations and multiple scattering noise. Reflection matrix approaches recording the maps of backscattered waves for all the possible…

Ultrasound (US) imaging is based on the time-reversal principle, in which individual channel RF measurements are back-propagated and accumulated to form an image after applying specific delays. While this time reversal is usually…

Computer Vision and Pattern Recognition · Computer Science 2019-01-08 Shujaat Khan , Jaeyoung Huh , Jong Chul Ye

We present a new approach for spatiotemporal focusing through complex scattering media by wave front shaping. Using a nonlinear feedback signal to shape the incident pulsed wave front, we show that the limit of a spatiotemporal matched…

Thanks to a Multiple Scattering Theory algorithm, we present a way to focus energy at the deep subwavelength scale, from the far-field, inside a cubic disordered bubble cloud by using broadband Time Reversal (TR). We show that the…

Soft Condensed Matter · Physics 2015-10-26 Maxime Lanoy , Romain Pierrat , Fabrice Lemoult , Mathias Fink , Valentin Leroy , Arnaud Tourin

We experimentally and numerically study the potential of photoacoustic-guiding for light focusing through scattering samples via wavefront-shaping and iterative optimization. We experimentally demonstrate that the focusing efficiency on an…

We introduce a metasurface-based system for the microwave hyperthermia treatment of brain tumors, where the metasurface is designed by the time-reversal technique for optimal focusing at the location of the tumor. Compared to previous…

Medical Physics · Physics 2023-01-04 Mohamad J. Hajiahmadi , Reza Faraji-Dana , Christophe Caloz
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