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The computational prediction of a protein structure from its sequence generally relies on a method to assess the quality of protein models. Most assessment methods rank candidate models using heavily engineered structural features, defined…

Biomolecules · Quantitative Biology 2018-11-26 Georgy Derevyanko , Sergei Grudinin , Yoshua Bengio , Guillaume Lamoureux

This study proposes an efficient neural network with convolutional layers to classify significantly class-imbalanced clinical data. The data are curated from the National Health and Nutritional Examination Survey (NHANES) with the goal of…

Quantitative Methods · Quantitative Biology 2020-04-24 Aniruddha Dutta , Tamal Batabyal , Meheli Basu , Scott T. Acton

In today's world of health care, brain tumor detection has become common. However, the manual brain tumor classification approach is time-consuming. So Deep Convolutional Neural Network (DCNN) is used by many researchers in the medical…

Image and Video Processing · Electrical Eng. & Systems 2024-11-22 Dhananjay Joshi , Bhupesh Kumar Singh , Kapil Kumar Nagwanshi , Nitin S. Choubey

In this paper, we present a strategy for training convolutional neural networks to effectively resolve interference arising from competing hypotheses relating to inter-categorical information throughout the network. The premise is based on…

Computer Vision and Pattern Recognition · Computer Science 2020-08-14 Md Amirul Islam , Matthew Kowal , Konstantinos G. Derpanis , Neil D. B. Bruce

Human metapneumovirus (hMPV) poses serious risks to pediatric, elderly, and immunocompromised populations. Traditional antibody discovery pipelines require 10-12 months, limiting their applicability for rapid outbreak response. This project…

Quantitative Methods · Quantitative Biology 2025-09-01 Shawnak Shivakumar , Matthew Sandora

One key task in virtual screening is to accurately predict the binding affinity ($\triangle$$G$) of protein-ligand complexes. Recently, deep learning (DL) has significantly increased the predicting accuracy of scoring functions due to the…

Quantitative Methods · Quantitative Biology 2022-06-28 Zechen Wang , Liangzhen Zheng , Yang Liu , Yuanyuan Qu , Yong-Qiang Li , Mingwen Zhao , Yuguang Mu , Weifeng Li

The detection of nuclei and cells in histology images is of great value in both clinical practice and pathological studies. However, multiple reasons such as morphological variations of nuclei or cells make it a challenging task where…

Computer Vision and Pattern Recognition · Computer Science 2021-06-28 Yibao Sun , Xingru Huang , Huiyu Zhou , Qianni Zhang

Metaproteomics are becoming widely used in microbiome research for gaining insights into the functional state of the microbial community. Current metaproteomics studies are generally based on high-throughput tandem mass spectrometry (MS/MS)…

Quantitative Methods · Quantitative Biology 2020-09-24 Xuan Guo , Shichao Feng

This paper presents regression models obtained from a process of blind prediction of peptide binding affinity from provided descriptors for several distinct datasets as part of the 2006 Comparative Evaluation of Prediction Algorithms…

The Gene or DNA sequence in every cell does not control genetic properties on its own; Rather, this is done through translation of DNA into protein and subsequent formation of a certain 3D structure. The biological function of a protein is…

Computational Engineering, Finance, and Science · Computer Science 2019-05-30 Leila Khalatbari , Mohammad Reza Kangavari , Saeid Hosseini , Hongzhi Yin , Ngai-Man Cheung

Relation classification is an important semantic processing task for which state-ofthe-art systems still rely on costly handcrafted features. In this work we tackle the relation classification task using a convolutional neural network that…

Computation and Language · Computer Science 2015-05-26 Cicero Nogueira dos Santos , Bing Xiang , Bowen Zhou

Transcription factors are proteins that regulate the expression of genes by binding to specific genomic regions known as Transcription Factor Binding Sites (TFBSs), typically located in the promoter regions of those genes. Accurate…

Machine Learning · Computer Science 2025-02-04 Nimisha Ghosh , Pratik Dutta , Daniele Santoni

Predicting protein properties such as solvent accessibility and secondary structure from its primary amino acid sequence is an important task in bioinformatics. Recently, a few deep learning models have surpassed the traditional window…

Machine Learning · Computer Science 2016-05-11 Zeming Lin , Jack Lanchantin , Yanjun Qi

The combination of policy search and deep neural networks holds the promise of automating a variety of decision-making tasks. Model Predictive Control (MPC) provides robust solutions to robot control tasks by making use of a dynamical model…

Robotics · Computer Science 2021-05-11 Yunlong Song , Davide Scaramuzza

Despite their renowned predictive power on i.i.d. data, convolutional neural networks are known to rely more on high-frequency patterns that humans deem superficial than on low-frequency patterns that agree better with intuitions about what…

Computer Vision and Pattern Recognition · Computer Science 2019-11-06 Haohan Wang , Songwei Ge , Eric P. Xing , Zachary C. Lipton

This paper focuses on improving the performance of current convolutional neural networks in visual recognition without changing the network architecture. A hierarchical matcher is proposed that builds chains of local binary neural networks…

Computer Vision and Pattern Recognition · Computer Science 2018-05-08 Lingfeng Zhang , Ioannis A. Kakadiaris

Despite the effectiveness of Convolutional Neural Networks (CNNs) for image classification, our understanding of the relationship between shape of convolution kernels and learned representations is limited. In this work, we explore and…

Computer Vision and Pattern Recognition · Computer Science 2016-11-30 Zhun Sun , Mete Ozay , Takayuki Okatani

Selecting the right drugs for the right patients is a primary goal of precision medicine. In this manuscript, we consider the problem of cancer drug selection in a learning-to-rank framework. We have formulated the cancer drug selection…

Machine Learning · Computer Science 2025-03-25 Yicheng He , Junfeng Liu , Xia Ning

Protein-protein interaction (PPI) prediction plays a pivotal role in deciphering cellular functions and disease mechanisms. To address the limitations of traditional experimental methods and existing computational approaches in cross-modal…

Machine Learning · Computer Science 2025-04-29 Shengrui XU , Tianchi Lu , Zikun Wang , Jixiu Zhai

Despite advances in feature representation, leveraging geometric relations is crucial for establishing reliable visual correspondences under large variations of images. In this work we introduce a Hough transform perspective on…

Computer Vision and Pattern Recognition · Computer Science 2021-09-14 Juhong Min , Seungwook Kim , Minsu Cho