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Two-photon (2P) microscopy is a powerful technique for deep-tissue fluorescence imaging; however, tissue scattering limits its effectiveness for depth imaging using conventional approaches. Despite typical strategies having been put forward…

Optics · Physics 2025-05-21 Lei Zhu , Bernhard Rauer , Hilton B. De Aguiar , Sylvain Gigan

We demonstrate dynamic and arbitrary multisite two-photon excitation in three dimensions using the holographic projection method. Rapid response (fourth dimension) is achieved through high-speed noniterative calculation of the hologram…

Single-beam super-resolution microscopy, also known as superlinear microscopy, exploits the nonlinear response of fluorescent probes in confocal microscopy. The technique requires no complex purpose-built system, light field modulation, or…

Confining light illumination in the three dimensions of space is a challenge for various applications. Among these, optogenetic methods developed for live experiments in cell biology would benefit from such a localized illumination as it…

We report the generation of strong, bright-beam intensity-difference squeezing down to measurement frequencies below 10 Hz. We generate two-mode squeezing in a four-wave mixing (4WM) process in Rb vapor, where the single-pass-gain nonlinear…

Direct exoplanet detection is limited by speckle noise in the point spread function (PSF) of the central star. This noise can be reduced by subtracting PSF images obtained simultaneously in adjacent narrow spectral bands using a…

Single-molecule microscopy has become an indispensable tool for biochemical analysis. The capability of characterizing distinct properties of individual molecules without averaging has provided us with a different perspective for the…

Applied Physics · Physics 2020-05-21 Miao-Hsuan Chien , Silvan Schmid

Efficient excitation of a single two-level system usually requires that the driving field is at the same frequency as the atomic transition. However, the scattered laser light in solid-state implementations can dominate over the single…

Three-dimensional spatiotemporal tracking of microscopic particles in multiple colors is a challenging optical imaging task. Existing approaches require a trade-off between photon-efficiency, field of view, mechanical complexity, spectral…

An experimental realization of high-precision direct frequency comb spectroscopy using counter-propagating femtosecond pulses on two-photon atomic transitions is presented. Doppler broadened background signal, hampering precision…

Atomic Physics · Physics 2013-07-11 Itan Barmes , Stefan Witte , Kjeld S. E. Eikema

We study two-photon excitation using biphotons generated via the process of spontaneous parametric down-conversion in a nonlinear crystal. We show that the focusing of these biphotons yields an excitation distribution that is essentially…

Multi-photon microscopy is a powerful tool in biomolecular research. Less complex and more cost effective excitation light sources will make this technique accessible to a broader community. Especially semiconductor diode seeded fiber…

Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit. However, due to its difficult implementation and high cost, the universal…

In recent years, with the increasing demand for indoor positioning service, visible light indoor positioning based on image sensors has been widely studied. However, many researches only put forward the relevant localization algorithm and…

Signal Processing · Electrical Eng. & Systems 2020-04-30 Shihuan Chen , Weipeng Guan , Zequn Tan , Shangsheng Wen , Manxi Liu , Jingmin Wang , Jingyi Li

We report a method for accelerated nanoscale nuclear magnetic resonance imaging by detecting several signals in parallel. Our technique relies on phase multiplexing, where the signals from different nuclear spin ensembles are encoded in the…

Mesoscale and Nanoscale Physics · Physics 2015-08-11 B. A. Moores , A. Eichler , Y. Tao , H. Takahashi , P. Navaretti , C. L. Degen

We show that the quantum Cram\'er-Rao bound on the precision of measurements of the optical phase gradient, or the wavefront tilt, with a beam of finite width is consistent with the Heisenberg uncertainty principle for a single-photon…

Quantum Physics · Physics 2020-07-22 Walker Larson , Bahaa E. A. Saleh

Two-dimensional (2D) fluorescence-excitation (2D-FLEX) spectroscopy is a recently proposed nonlinear femtosecond technique for the detection of photoinduced dynamics. The method records a time-resolved fluorescence signal in its excitation-…

Chemical Physics · Physics 2024-06-24 Sebastian V. Pios , Maxim F. Gelin , Luis Vasquez , Jürgen Hauer , Lipeng Chen

Two-mode squeezing is central to entangled-photon generation and nonlinear interferometry, yet standard perturbative low-gain treatments and Gaussian formalisms can obscure the interference of photon-number amplitudes, especially in…

Quantum Physics · Physics 2026-02-11 Xuemei Gu , Carlos Ruiz-Gonzalez , Mario Krenn

Detectors inherently capable of resolving photon numbers have undergone a significant development recently, and this is expected to affect multiplexed periodic single-photon sources where such detectors can find their applications. We…

Quantum Physics · Physics 2020-07-29 Ferenc Bodog , Matyas Mechler , Matyas Koniorczyk , Peter Adam

Quantum correlation microscopy is an emerging technique for improving optical resolution. By taking advantage of the quantum statistics from single-photon fluorophores, more information about the emitters (including number and location) is…

Optics · Physics 2025-05-19 Jaret J. Vasquez-Lozano , Qiang Sun , Shuo Li , Andrew D. Greentree