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The problem of computing an exact experimental design that is optimal for the least-squares estimation of the parameters of a regression model is considered. We show that this problem can be solved via mixed-integer linear programming…

Computation · Statistics 2024-06-18 Radoslav Harman , Samuel Rosa

Mixed Integer Linear Programming (MILP) is a fundamental tool for modeling combinatorial optimization problems. Recently, a growing body of research has used machine learning to accelerate MILP solving. Despite the increasing popularity of…

Machine Learning · Computer Science 2024-10-29 Weimin Huang , Taoan Huang , Aaron M Ferber , Bistra Dilkina

Mixed Integer Linear Programming (MILP) is essential for modeling complex decision-making problems but faces challenges in computational tractability and requires expert formulation. Current deep learning approaches for MILP focus on…

Machine Learning · Computer Science 2025-02-24 Sirui Li , Janardhan Kulkarni , Ishai Menache , Cathy Wu , Beibin Li

Mixed Integer Linear Programming (MILP) is a pillar of mathematical optimization that offers a powerful modeling language for a wide range of applications. During the past decades, enormous algorithmic progress has been made in solving…

Optimization and Control · Mathematics 2024-02-09 Lara Scavuzzo , Karen Aardal , Andrea Lodi , Neil Yorke-Smith

Mixed Integer Linear Programs (MILPs) are highly flexible and powerful tools for modeling and solving complex real-world combinatorial optimization problems. Recently, machine learning (ML)-guided approaches have demonstrated significant…

Artificial Intelligence · Computer Science 2025-06-13 Junyang Cai , Taoan Huang , Bistra Dilkina

This applied research article explores the application of Mixed-Integer Linear Programming (MILP) to address line-balancing challenges in the garment industry, focusing on optimizing production processes under multiple constraints. By…

Optimization and Control · Mathematics 2025-04-10 Ray Wai Man Kong , Ding Ning , Theodore Ho Tin Kong

In this paper, we investigate the constraint typology of mixed-integer linear programming MILP formulations. MILP is a commonly used mathematical programming technique for modelling and solving real-life scheduling, routing, planning,…

Artificial Intelligence · Computer Science 2021-03-02 Vicky Mak-Hau , John Yearwood , William Moran

Deep brain stimulation (DBS) programming remains a complex and time-consuming process, requiring manual selection of stimulation parameters to achieve therapeutic effects while minimizing adverse side-effects. This study explores…

Systems and Control · Electrical Eng. & Systems 2025-02-12 Anna Franziska Frigge , Alexander Medvedev

Mixed Integer Linear Programs (MILPs) are essential tools for solving planning and scheduling problems across critical industries such as construction, manufacturing, and logistics. However, their widespread adoption is limited by long…

Machine Learning · Computer Science 2025-06-10 Xiaoke Wang , Batuhan Altundas , Zhaoxin Li , Aaron Zhao , Matthew Gombolay

Mixed integer linear programming (MILP) is a powerful tool for planning and control problems because of its modeling capability and the availability of good solvers. However, for large models, MILP methods suffer computationally. In this…

Robotics · Computer Science 2007-05-23 Matthew Earl , Raffaello D'Andrea

Mixed-integer linear programming (MILP) is widely employed for modeling combinatorial optimization problems. In practice, similar MILP instances with only coefficient variations are routinely solved, and machine learning (ML) algorithms are…

Optimization and Control · Mathematics 2023-03-07 Qingyu Han , Linxin Yang , Qian Chen , Xiang Zhou , Dong Zhang , Akang Wang , Ruoyu Sun , Xiaodong Luo

We transform join ordering into a mixed integer linear program (MILP). This allows to address query optimization by mature MILP solver implementations that have evolved over decades and steadily improved their performance. They offer…

Databases · Computer Science 2015-11-09 Immanuel Trummer , Christoph Koch

The goal of survey design is often to minimize the errors associated with inference: the total of bias and variance. Random surveys are common because they allow the use of theoretically unbiased estimators. In practice however, such…

Methodology · Statistics 2023-02-14 Connie Okasaki , Sándor F. Tóth , Andrew M. Berdahl

Mixed-integer programming (MIP) is a well-established framework for computer-aided molecular design (CAMD). By precisely encoding the molecular space and score functions, e.g., a graph neural network, the molecular design problem is…

Computational Engineering, Finance, and Science · Computer Science 2024-11-26 Shiqiang Zhang , Christian W. Feldmann , Frederik Sandfort , Miriam Mathea , Juan S. Campos , Ruth Misener

Finding optimal join orders is among the most crucial steps to be performed by query optimisers. Though extensively studied in data management research, the problem remains far from solved: While query optimisers rely on exhaustive search…

Databases · Computer Science 2025-10-24 Manuel Schönberger , Immanuel Trummer , Wolfgang Mauerer

Machine Learning models are increasingly used for decision making, in particular in high-stakes applications such as credit scoring, medicine or recidivism prediction. However, there are growing concerns about these models with respect to…

Machine Learning · Computer Science 2023-04-12 Julien Rouzot , Julien Ferry , Marie-José Huguet

While Mixed-integer linear programming (MILP) is NP-hard in general, practical MILP has received roughly 100--fold speedup in the past twenty years. Still, many classes of MILPs quickly become unsolvable as their sizes increase, motivating…

Machine Learning · Computer Science 2023-05-29 Ziang Chen , Jialin Liu , Xinshang Wang , Jianfeng Lu , Wotao Yin

In this paper, we propose a new mixed-integer linear programming (MILP) model ontology and a novel constraint typology of MILP formulations. MILP is a commonly used mathematical programming technique for modelling and solving real-life…

Artificial Intelligence · Computer Science 2021-03-02 Bahadorreza Ofoghi , Vicky Mak , John Yearwood

Mixed Integer Linear Programs (MILP) are well known to be NP-hard (Non-deterministic Polynomial-time hard) problems in general. Even though pure optimization-based methods, such as constraint generation, are guaranteed to provide an optimal…

Optimization and Control · Mathematics 2022-07-18 Asunción Jiménez-Cordero , Juan Miguel Morales , Salvador Pineda

Influence diagrams represent decision-making problems with interdependencies between random events, decisions, and consequences. Traditionally, they have been solved using algorithms that determine the expected utility-maximizing decision…

Optimization and Control · Mathematics 2026-01-14 Topias Terho , Fabricio Oliveira , Ahti Salo , Pedro Munari
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