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Alzheimer's disease (AD) constitutes a neurodegenerative disease with serious consequences to peoples' everyday lives, if it is not diagnosed early since there is no available cure. Alzheimer's is the most common cause of dementia, which…

Computation and Language · Computer Science 2023-01-18 Loukas Ilias , Dimitris Askounis , John Psarras

Early dementia diagnosis requires biomarkers sensitive to both structural and functional brain changes. While structural neuroimaging biomarkers have progressed significantly, objective functional biomarkers of early cognitive decline…

Neurons and Cognition · Quantitative Biology 2025-04-16 Tomasz M. Rutkowski , Stanisław Narębski , Mihoko Otake-Matsuura , Tomasz Komendziński

Multiple modalities of biomarkers have been proved to be very sensitive in assessing the progression of Alzheimer's disease (AD), and using these modalities and machine learning algorithms, several approaches have been proposed to assist in…

Machine Learning · Statistics 2017-12-05 Chen Fang , Panuwat Janwattanapong , Chunfei Li , Malek Adjouadi

The aging population of the U.S. drives the prevalence of Alzheimer's disease. Brookmeyer et al. forecasts approximately 15 million Americans will have either clinical AD or mild cognitive impairment by 2060. In response to this urgent…

Image and Video Processing · Electrical Eng. & Systems 2023-12-01 Long Chen , Liben Chen , Binfeng Xu , Wenxin Zhang , Narges Razavian

For effective treatment of Alzheimer disease (AD), it is important to identify subjects who are most likely to exhibit rapid cognitive decline. Herein, we developed a novel framework based on a deep convolutional neural network which can…

Computer Vision and Pattern Recognition · Computer Science 2017-04-21 Hongyoon Choi , Kyong Hwan Jin

Early and accessible detection of Alzheimer's disease (AD) remains a major challenge, as current diagnostic methods often rely on costly and invasive biomarkers. Speech and language analysis has emerged as a promising non-invasive and…

Audio and Speech Processing · Electrical Eng. & Systems 2026-03-06 Franziska Braun , Christopher Witzl , Florian Hönig , Elmar Nöth , Tobias Bocklet , Korbinian Riedhammer

Alzheimers Disease AD is an acute neuro disease that degenerates the brain cells and thus leads to memory loss progressively. It is a fatal brain disease that mostly affects the elderly. It steers the decline of cognitive and biological…

Machine Learning · Computer Science 2023-04-20 Nair Bini Balakrishnan , P. S. Sreeja , Jisha Jose Panackal

Early diagnosis of Alzheimer's disease and related dementias (ADRD) is critical for timely intervention, yet most diagnoses are delayed until advanced stages. While comprehensive patient narratives are essential for accurate diagnosis,…

Human-Computer Interaction · Computer Science 2026-01-28 Andrew G. Breithaupt , Nayoung Choi , James D. Finch , Jeanne M. Powell , Arin L. Nelson , Oz A. Alon , Howard J. Rosen , Jinho D. Choi

Dementia affects cognitive functions of adults, including memory, language, and behaviour. Standard diagnostic biomarkers such as MRI are costly, whilst neuropsychological tests suffer from sensitivity issues in detecting dementia onset.…

Computation and Language · Computer Science 2023-12-27 Dimitris Gkoumas , Bo Wang , Adam Tsakalidis , Maria Wolters , Arkaitz Zubiaga , Matthew Purver , Maria Liakata

Current progress in the artificial intelligence domain has led to the development of various types of AI-powered dementia assessments, which can be employed to identify patients at the early stage of dementia. It can revolutionize the…

Dementia diagnosis requires a series of different testing methods, which is complex and time-consuming. Early detection of dementia is crucial as it can prevent further deterioration of the condition. This paper utilizes a speech…

Computation and Language · Computer Science 2023-12-18 Zih-Jyun Lin , Yi-Ju Chen , Po-Chih Kuo , Likai Huang , Chaur-Jong Hu , Cheng-Yu Chen

A significant number of studies apply acoustic and linguistic characteristics of human speech as prominent markers of dementia and depression. However, studies on discriminating depression from dementia are rare. Co-morbid depression is…

Computation and Language · Computer Science 2022-10-10 Malikeh Ehghaghi , Frank Rudzicz , Jekaterina Novikova

Dementia is associated with language disorders which impede communication. Here, we automatically learn linguistic disorder patterns by making use of a moderately-sized pre-trained language model and forcing it to focus on reformulated…

Computation and Language · Computer Science 2023-10-17 Dimitris Gkoumas , Matthew Purver , Maria Liakata

Language is a valuable source of clinical information in Alzheimer's Disease, as it declines concurrently with neurodegeneration. Consequently, speech and language data have been extensively studied in connection with its diagnosis. This…

Artificial Intelligence · Computer Science 2020-10-14 Sofia de la Fuente Garcia , Craig Ritchie , Saturnino Luz

Cognitive decline is a sign of Alzheimer's disease (AD), and there is evidence that tracking a person's eye movement, using eye tracking devices, can be used for the automatic identification of early signs of cognitive decline. However,…

Computation and Language · Computer Science 2019-10-02 Bahman Mirheidari , Yilin Pan , Traci Walker , Markus Reuber , Annalena Venneri , Daniel Blackburn , Heidi Christensen

Alzheimer's disease (AD) and its prodromal stage, Mild Cognitive Impairment (MCI), are associated with subtle declines in memory, attention, and language that often go undetected until late in progression. Traditional diagnostic tools such…

Human-Computer Interaction · Computer Science 2025-12-30 Ananya Drishti , Mahfuza Farooque

In this work, we present a novel perspective on cognitive impairment classification from speech by integrating speech foundation models that explicitly recognize speech dialects. Our motivation is based on the observation that individuals…

Sound · Computer Science 2026-01-14 Tiantian Feng , Anfeng Xu , Jinkook Lee , Shrikanth Narayanan

Deep learning systems often struggle with processing long sequences, where computational complexity can become a bottleneck. Current methods for automated dementia detection using speech frequently rely on static, time-agnostic features or…

Sound · Computer Science 2025-10-02 Chukwuemeka Ugwu , Oluwafemi Oyeleke

A number of life threatening neuro-degenerative disorders had degraded the quality of life for the older generation in particular. Dementia is one such symptom which may lead to a severe condition called Alzheimer's disease if not detected…

Neural and Evolutionary Computing · Computer Science 2024-02-01 Anuvab Sen , Udayon Sen , Subhabrata Roy

With the global population aging rapidly, Alzheimer's disease (AD) is particularly prominent in older adults, which has an insidious onset and leads to a gradual, irreversible deterioration in cognitive domains (memory, communication,…

Audio and Speech Processing · Electrical Eng. & Systems 2023-03-15 Jinchao Li , Kaitao Song , Junan Li , Bo Zheng , Dongsheng Li , Xixin Wu , Xunying Liu , Helen Meng
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