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Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between near-neighbor receptor molecules; the properties…

Soft Condensed Matter · Physics 2009-10-31 Chinlin Guo , Herbert Levine

The spreading of bacterial populations is central to processes in agriculture, the environment, and medicine. However, existing models of spreading typically focus on cells in unconfined settings--despite the fact that many bacteria inhabit…

Populations and Evolution · Quantitative Biology 2022-06-07 Daniel B. Amchin , Jenna A. Ott , Tapomoy Bhattacharjee , Sujit S. Datta

Flocking is ubiquitous in nature and emerges due to short- or long-range alignment interactions among self-propelled agents. Two unfriendly species that antialign or even interact nonreciprocally show more complex collective phenomena,…

Statistical Mechanics · Physics 2025-12-17 Jiwon Choi , Jae Dong Noh , Heiko Rieger

We consider a system of interacting Moran models with seed-banks. Individuals live in colonies and are subject to resampling and migration as long as they are $active$. Each colony has a seed-bank into which individuals can retreat to…

Probability · Mathematics 2021-07-29 Frank den Hollander , Shubhamoy Nandan

Inspired by motile cells in tissue formation, we find that active systems of self-aligning adhesive particles undergo ballistic aggregation through a flocking transition. This kinetic regime emerges when the cluster persistence length grows…

Key to collective cell migration is the ability of cells to rearrange their position with respect to their neighbors. Recent theory and experiments demonstrated that cellular rearrangements are facilitated by cell shape, with cells having…

Biological Physics · Physics 2020-02-05 Aashrith Saraswathibhatla , Jacob Notbohm

Nonreciprocal interactions have recently attracted growing interest in nonequilibrium physics. In particular, breaking action-reaction symmetry has been proposed as a mechanism for collective motion, yet controlled experimental realizations…

We investigate the phase behaviour of mixtures of two populations of colloidal particles dispersed in a binary solvent system near its critical composition. The surfaces of particles are chemically modified to elicit a specific solvent…

Soft Condensed Matter · Physics 2026-02-16 T. E. Kodger , N. Farahmand Bafi , M. Labbé-Laurent , E. Steijlen , A. Maciolek , P. Schall

We study a two-species bidirectional exclusion process, and a single species variant, which is motivated by the motion of organelles and vesicles along microtubules. Specifically, we are interested in the clustering of the particles and…

Statistical Mechanics · Physics 2020-03-17 Jim Chacko , Sudipto Muhuri , Goutam Tripathy

Controlling growth via cell division is crucial in the development of higher organisms, and yet the mechanisms through which this is achieved, e.g., in epithelial tissue, is not yet fully understood. We show that by coupling the cell cycle…

Tissues and Organs · Quantitative Biology 2024-06-11 Chandrashekar Kuyyamudi , Shakti N. Menon , Fernando Casares , Sitabhra Sinha

This work focuses on the formation of mating aggregates in zooplankton. In particular, sexual encounters are behaviourally supported by males actively swimming in search for females, and approaching them for mating once they are found.…

Populations and Evolution · Quantitative Biology 2022-05-19 Ron Shnapp , François-Gaël Michalec , Markus Holzner

During cell migration, cells become polarized, change their shape, and move in response to various internal and external cues. Cell polarization is defined through the spatio-temporal organization of molecules such as PI3K or small GTPases,…

Biological Physics · Physics 2016-07-07 Fabian Spill , Vivi Andasari , Michael Mak , Roger D. Kamm , Muhammad H. Zaman

Movement of cell clusters along extracellular matrices (ECM) during tissue development, wound healing, and early stage of cancer invasion involve various inter-connected migration modes such as: (1) cell movement within clusters, (2)…

Cell Behavior · Quantitative Biology 2023-02-14 Ivana Pajic-Lijakovic , Milan Milivojevic

The combination of protrusions and retractions in the movement of polarized cells leads to understand the effect of possible synchronisation between the two ends of the cells. This synchronisation, in turn, could lead to different dynamics…

Cell Behavior · Quantitative Biology 2021-09-21 Gissell Estrada-Rodriguez , Benoit Perthame

Biomolecular condensates are essential for cellular organization and result from phase separation in systems far from thermodynamic equilibrium. Among various models, chemically active droplets play a significant role, consisting of…

Soft Condensed Matter · Physics 2025-05-19 Jacques Fries , Roxanne Berthin , Chengjie Luo , Marie Jardat , David Zwicker , Vincent Dahirel , Pierre Illien

A generically observed mechanism that drives the self-organization of living systems is interaction via chemical signals among the individual elements -- which may represent cells, bacteria, or even enzymes. Here we propose a novel…

Biologists have long observed periodic-like oxygen consumption oscillations in yeast populations under certain conditions and several unsatisfactory explanations for this phenomenon have been proposed. These "autonomous oscillations" have…

Dynamical Systems · Mathematics 2011-12-02 Erik M. Boczko , Tomas Gedeon , Chris C. Stowers , Todd Young

Recent advances in high-resolution experimental methods have highlighted the significance of cell signal pathway crosstalk and localised signalling activity in the development and disease of numerous biological systems. The investigation of…

Dynamical Systems · Mathematics 2022-09-19 Joshua W. Moore , Trevor C. Dale , Thomas E. Woolley

Bacterial colonies are a well-known example of living active matter, exhibiting collective behaviors such as nematic alignment and collective motion that play an important role in the spread of microbial infections. While the underlying…

How thousands of microtubules and molecular motors self-organize into spindles remains poorly understood. By combining static, nanometer-resolution, large-scale electron tomography reconstructions and dynamic, optical-resolution, polarized…