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Spatial epidemiology identifies the drivers of elevated population-level disease risks, using disease counts, exposures and known confounders at the areal unit level. Poisson regression models are typically used for inference, which…

Methodology · Statistics 2026-02-03 Duncan Lee , Vinny Davies

Estimation of the allele frequency at genetic markers is a key ingredient in biological and biomedical research, such as studies of human genetic variation or of the genetic etiology of heritable traits. As genetic data becomes increasingly…

Applications · Statistics 2007-12-18 Marc Coram , Hua Tang

In many applications, different populations are compared using data that are sampled in a biased manner. Under sampling biases, standard methods that estimate the difference between the population means yield unreliable inferences. Here we…

Statistics Theory · Mathematics 2019-11-12 Dave Zachariah , Petre Stoica

Representative risk estimation is fundamental to clinical decision-making. However, risks are often estimated from non-representative epidemiologic studies, which usually underrepresent minorities. "Model-based" methods use population…

Methodology · Statistics 2023-04-12 Lingxiao Wang , Yan Li , Barry I. Graubard , Hormuzd A. Katki

Conformal Predictive Systems (CPS) offer a versatile framework for constructing predictive distributions, allowing for calibrated inference and informative decision-making. However, their applicability has been limited to scenarios adhering…

Machine Learning · Computer Science 2024-10-17 Jef Jonkers , Glenn Van Wallendael , Luc Duchateau , Sofie Van Hoecke

Estimating average causal effect (ACE) is useful whenever we want to know the effect of an intervention on a given outcome. In the absence of a randomized experiment, many methods such as stratification and inverse propensity weighting have…

Machine Learning · Computer Science 2019-07-11 Rathin Desai , Amit Sharma

Regression analysis is commonly conducted in survey sampling. However, existing methods fail when the relationships vary across different areas or domains. In this paper, we propose a unified framework to study the group-wise covariate…

Methodology · Statistics 2024-09-25 Mingjun Gang , Xin Wang , Zhonglei Wang , Wei Zhong

Ancestry-specific proteome-wide association studies (PWAS) based on genetically predicted protein expression can reveal complex disease etiology specific to certain ancestral groups. These studies require ancestry-specific models for…

Applications · Statistics 2024-04-26 Aaron J. Molstad , Yanwei Cai , Alexander P. Reiner , Charles Kooperberg , Wei Sun , Li Hsu

In the age of big data, nonprobability surveys are becoming increasingly abundant. Data integration techniques involving both probability and nonprobability surveys are being extensively used for providing improved estimates for finite…

Applications · Statistics 2025-10-17 Aditi Sen , Partha Lahiri

Rejection sampling is a technique for sampling from difficult distributions. However, its use is limited due to a high rejection rate. Common adaptive rejection sampling methods either work only for very specific distributions or without…

Machine Learning · Statistics 2026-04-27 Akram Erraqabi , Michal Valko , Alexandra Carpentier , Odalric-Ambrym Maillard

Inverse propensity weighting (IPW) is a popular method for estimating treatment effects from observational data. However, its correctness relies on the untestable (and frequently implausible) assumption that all confounders have been…

Statistics Theory · Mathematics 2023-08-04 Jacob Dorn , Kevin Guo

Inverse probability of treatment weighting (IPTW), which has been used to estimate sample average treatment effects (SATE) using observational data, tenuously relies on the positivity assumption and the correct specification of the…

Methodology · Statistics 2019-05-23 Nathan Kallus , Brenton Pennicooke , Michele Santacatterina

Weighting estimators based on propensity scores are widely used for causal estimation in a variety of contexts, such as observational studies, marginal structural models and interference. They enjoy appealing theoretical properties such as…

Methodology · Statistics 2021-10-06 Linbo Wang , Yuexia Zhang , Thomas S. Richardson , Xiao-Hua Zhou

We propose the periodic scaled Korobov kernel (PSKK) method for nonparametric density estimation on $\mathbb{R}^d$. By first wrapping the target density into a periodic version through modulo operation and subsequently applying kernel ridge…

Statistics Theory · Mathematics 2025-12-23 Ziyang Ye , Haoyuan Tan , Xiaoqun Wang , Zhijian He

Demographic models built from genetic data play important roles in illuminating prehistorical events and serving as null models in genome scans for selection. We introduce an inference method based on the joint frequency spectrum of genetic…

Populations and Evolution · Quantitative Biology 2010-05-10 Ryan N. Gutenkunst , Ryan D. Hernandez , Scott H. Williamson , Carlos D. Bustamante

The ability to quantify information transmission is crucial for the analysis and design of natural and engineered systems. The information transmission rate is the fundamental measure for systems with time-varying signals, yet computing it…

Biological Physics · Physics 2025-09-26 Manuel Reinhardt , Gašper Tkačik , Pieter Rein ten Wolde

We address measurement error bias in propensity score (PS) analysis due to covariates that are latent variables. In the setting where latent covariate $X$ is measured via multiple error-prone items $\mathbf{W}$, PS analysis using several…

Methodology · Statistics 2020-02-13 Trang Quynh Nguyen , Elizabeth A. Stuart

Empirical best prediction (EBP) is a well-known method for producing reliable proportion estimates when the primary data source provides only small or no sample from finite populations. There are potential challenges in implementing…

Methodology · Statistics 2025-01-22 Aditi Sen , Partha Lahiri

We discuss a new weighted likelihood method for parametric estimation. The method is motivated by the need for generating a simple estimation strategy which provides a robust solution that is simultaneously fully efficient when the model is…

Methodology · Statistics 2019-08-29 Suman Majumder , Adhidev Biswas , Tania Roy , Subir Kumar Bhandari , Ayanendranath Basu

Selective inference (post-selection inference) is a methodology that has attracted much attention in recent years in the fields of statistics and machine learning. Naive inference based on data that are also used for model selection tends…

Methodology · Statistics 2021-11-25 Yoshiyuki Ninomiya , Yuta Umezu , Ichiro Takeuchi