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We study the theoretical problem of synthesizing multiple DNA strands under spatial constraints, motivated by large-scale DNA synthesis technologies. In this setting, strands are arranged in an array and synthesized according to a fixed…

Information Theory · Computer Science 2026-01-14 Boaz Moav , Ryan Gabrys , Eitan Yaakobi

The engineered control of cellular function through the design of synthetic genetic networks is becoming plausible. Here we show how a naturally occurring network can be used as a parts list for artificial network design, and how model…

Biological Physics · Physics 2009-11-07 Jeff Hasty , Farren Isaacs , Milos Dolnik , David McMillen , J. J. Collins

The financial industry relies on deep learning models for making important decisions. This adoption brings new danger, as deep black-box models are known to be vulnerable to adversarial attacks. In computer vision, one can shape the output…

Machine Learning · Computer Science 2024-08-27 Alina Ermilova , Elizaveta Kovtun , Dmitry Berestnev , Alexey Zaytsev

Current techniques in sequencing a genome allow a service provider (e.g. a sequencing company) to have full access to the genome information, and thus the privacy of individuals regarding their lifetime secret is violated. In this paper, we…

Genomics · Quantitative Biology 2018-11-28 Ali Gholami , Mohammad Ali Maddah-Ali , Seyed Abolfazl Motahari

Portable genome sequencing technology is revolutionizing genomic research by providing a faster, more flexible method of sequencing DNA and RNA [1, 2]. The unprecedented shift from bulky stand-alone benchtop equipment confined in a…

Cryptography and Security · Computer Science 2024-07-18 Carson Stillman , Jonathan E. Bravo , Christina Boucher , Sara Rampazzi

AI-enabled synthetic biology has tremendous potential but also significantly increases biorisks and brings about a new set of dual use concerns. The picture is complicated given the vast innovations envisioned to emerge by combining…

Other Quantitative Biology · Quantitative Biology 2024-03-08 Trond Arne Undheim

Dataset distillation (DD) enhances training efficiency and reduces bandwidth by condensing large datasets into smaller synthetic ones. It enables models to achieve performance comparable to those trained on the raw full dataset and has…

Cryptography and Security · Computer Science 2025-02-07 Ziyuan Yang , Ming Yan , Yi Zhang , Joey Tianyi Zhou

Deep neural networks (DNNs) are vulnerable to backdoor attacks, where the adversary manipulates a small portion of training data such that the victim model predicts normally on the benign samples but classifies the triggered samples as the…

Computer Vision and Pattern Recognition · Computer Science 2024-06-07 Yinghua Gao , Yiming Li , Xueluan Gong , Zhifeng Li , Shu-Tao Xia , Qian Wang

Large genomic datasets are now created through numerous activities, including recreational genealogical investigations, biomedical research, and clinical care. At the same time, genomic data has become valuable for reuse beyond their…

Cryptography and Security · Computer Science 2021-12-28 Rajagopal Venkatesaramani , Zhiyu Wan , Bradley A. Malin , Yevgeniy Vorobeychik

With the advancement of AI generative techniques, Deepfake faces have become incredibly realistic and nearly indistinguishable to the human eye. To counter this, Deepfake detectors have been developed as reliable tools for assessing face…

Cryptography and Security · Computer Science 2025-05-14 Shuaiwei Yuan , Junyu Dong , Yuezun Li

Deep neural networks are vulnerable to backdoor attacks, a type of adversarial attack that poisons the training data to manipulate the behavior of models trained on such data. Clean-label attacks are a more stealthy form of backdoor attacks…

Machine Learning · Computer Science 2024-07-17 Quang H. Nguyen , Nguyen Ngoc-Hieu , The-Anh Ta , Thanh Nguyen-Tang , Kok-Seng Wong , Hoang Thanh-Tung , Khoa D. Doan

The potential of synthetic biology techniques for designing complex cellular circuits able to solve complicated computations opens a whole domain of exploration, beyond experiments and theory. Such cellular circuits could be used to carry…

Neurons and Cognition · Quantitative Biology 2013-10-21 Luís F. Seoane , Ricard V. Solé

Advances in synthetic biology and nanotechnology have contributed to the design of tools that can be used to control, reuse, modify, and re-engineer cells' structure, as well as enabling engineers to effectively use biological cells as…

Networking and Internet Architecture · Computer Science 2021-06-29 Sidra Zafar , Mohsin Nazir , Taimur Bakhshi , Hasan Ali Khattak , Sarmadullah Khan , Muhammad Bilal , Kim-Kwang Raymond Choo , Kyung-Sup Kwak7 , Aneeqa Sabah

Visually realistic GAN-generated images have recently emerged as an important misinformation threat. Research has shown that these synthetic images contain forensic traces that are readily identifiable by forensic detectors. Unfortunately,…

Computer Vision and Pattern Recognition · Computer Science 2022-06-23 Xinwei Zhao , Matthew C. Stamm

The alarming rise in the quantity of malware in the last few years poses a serious challenge to the security community and requires urgent response. However, current countermeasures seem to be no longer effective. Thus, it is our belief…

Cryptography and Security · Computer Science 2015-01-20 Elzbieta Rzeszutko , Wojciech Mazurczyk

DNA fingerprinting and matching for identifying suspects has been a common practice in criminal investigation. Such proceedings involve multiple parties such as investigating agencies, suspects and forensic labs. A major challenge in such…

Cryptography and Security · Computer Science 2024-09-24 Sankha Das

Data-driven control has emerged as a powerful paradigm for synthesizing controllers directly from data, bypassing explicit model identification. However, this reliance on data introduces new and largely unexplored vulnerabilities. In this…

Optimization and Control · Mathematics 2026-04-10 Vijayanand Digge , Martina Vanelli , Ahmad W. Al-Dabbagh , Julien M. Hendrickx , Gianluca Bianchin

DNA-based storage offers unprecedented density and durability, but its scalability is fundamentally limited by the efficiency of parallel strand synthesis. Existing methods either allow unconstrained nucleotide additions to individual…

Information Theory · Computer Science 2025-10-27 Boaz Moav , Ryan Gabrys , Eitan Yaakobi

Together with impressive advances touching every aspect of our society, AI technology based on Deep Neural Networks (DNN) is bringing increasing security concerns. While attacks operating at test time have monopolised the initial attention…

Cryptography and Security · Computer Science 2021-11-17 Wei Guo , Benedetta Tondi , Mauro Barni

Speech synthesis technology has brought great convenience, while the widespread usage of realistic deepfake audio has triggered hazards. Malicious adversaries may unauthorizedly collect victims' speeches and clone a similar voice for…

Sound · Computer Science 2025-04-15 Zhisheng Zhang , Derui Wang , Qianyi Yang , Pengyang Huang , Junhan Pu , Yuxin Cao , Kai Ye , Jie Hao , Yixian Yang