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Backpropagation is the core learning mechanism underlying deep learning. However, whether and how this algorithm is implemented in the brain remains highly debated. In particular, while forward activations of pretrained models reliably map…

The brain processes information through many layers of neurons. This deep architecture is representationally powerful, but it complicates learning by making it hard to identify the responsible neurons when a mistake is made. In machine…

Neurons and Cognition · Quantitative Biology 2014-11-04 Timothy P. Lillicrap , Daniel Cownden , Douglas B. Tweed , Colin J. Akerman

With an ever-growing number of parameters defining increasingly complex networks, Deep Learning has led to several breakthroughs surpassing human performance. As a result, data movement for these millions of model parameters causes a…

Neural and Evolutionary Computing · Computer Science 2023-04-12 Christopher Wolters , Brady Taylor , Edward Hanson , Xiaoxuan Yang , Ulf Schlichtmann , Yiran Chen

Deep learning is emerging as a new paradigm for solving inverse imaging problems. However, the deep learning methods often lack the assurance of traditional physics-based methods due to the lack of physical information considerations in…

Image and Video Processing · Electrical Eng. & Systems 2020-07-20 Dongdong Chen , Mike E. Davies

It is unclear how changing the learning rule of a deep neural network alters its learning dynamics and representations. To gain insight into the relationship between learned features, function approximation, and the learning rule, we…

Machine Learning · Statistics 2023-05-29 Blake Bordelon , Cengiz Pehlevan

Learning depends on changes in synaptic connections deep inside the brain. In multilayer networks, these changes are triggered by error signals fed back from the output, generally through a stepwise inversion of the feedforward processing…

Neurons and Cognition · Quantitative Biology 2021-01-05 William F. Podlaski , Christian K. Machens

Artificial Intelligence algorithms have been steadily increasing in popularity and usage. Deep Learning, allows neural networks to be trained using huge datasets and also removes the need for human extracted features, as it automates the…

Neural and Evolutionary Computing · Computer Science 2020-05-11 Vasco Lopes , Paulo Fazendeiro

Understanding the mechanisms through which neural networks extract statistics from input-label pairs through feature learning is one of the most important unsolved problems in supervised learning. Prior works demonstrated that the gram…

Machine Learning · Statistics 2024-11-19 Daniel Beaglehole , Ioannis Mitliagkas , Atish Agarwala

Training a neural network using backpropagation algorithm requires passing error gradients sequentially through the network. The backward locking prevents us from updating network layers in parallel and fully leveraging the computing…

Machine Learning · Computer Science 2019-05-30 Zhouyuan Huo , Bin Gu , Heng Huang

Backpropagation is widely used to train artificial neural networks, but its relationship to synaptic plasticity in the brain is unknown. Some biological models of backpropagation rely on feedback projections that are symmetric with…

Neurons and Cognition · Quantitative Biology 2023-02-08 Navid Shervani-Tabar , Robert Rosenbaum

The backpropagation algorithm remains the dominant and most successful method for training deep neural networks (DNNs). At the same time, training DNNs at scale comes at a significant computational cost and therefore a high carbon…

Machine Learning · Computer Science 2025-11-12 Sander Dalm , Joshua Offergeld , Nasir Ahmad , Marcel van Gerven

Deep neural networks give us a powerful method to model the training dataset's relationship between input and output. We can regard that as a complex adaptive system consisting of many artificial neurons that work as an adaptive memory as a…

Disordered Systems and Neural Networks · Physics 2024-05-08 Kenichi Nakazato

We propose that learning in deep neural networks proceeds in two phases: a rapid curve fitting phase followed by a slower compression or coarse graining phase. This view is supported by the shared temporal structure of three phenomena:…

High Energy Physics - Theory · Physics 2025-07-28 Robert de Mello Koch , Animik Ghosh

Backpropagation is driving today's artificial neural networks (ANNs). However, despite extensive research, it remains unclear if the brain implements this algorithm. Among neuroscientists, reinforcement learning (RL) algorithms are often…

Neurons and Cognition · Quantitative Biology 2020-04-24 Benjamin James Lansdell , Prashanth Ravi Prakash , Konrad Paul Kording

Recent years have witnessed the outstanding success of deep learning in various fields such as vision and natural language processing. This success is largely indebted to the massive size of deep learning models that is expected to increase…

Machine Learning · Computer Science 2023-06-14 Ali Momeni , Babak Rahmani , Matthieu Mallejac , Philipp Del Hougne , Romain Fleury

Deep learning has shown impressive performance on challenging perceptual tasks and has been widely used in software to provide intelligent services. However, researchers found deep neural networks vulnerable to adversarial examples. Since…

Computer Vision and Pattern Recognition · Computer Science 2021-03-18 Haowen Liu , Ping Yi , Hsiao-Ying Lin , Jie Shi , Weidong Qiu

It is a central challenge in deep learning to understand how neural networks learn representations. A leading approach is the Neural Feature Ansatz (NFA) (Radhakrishnan et al. 2024), a conjectured mechanism for how feature learning occurs.…

Machine Learning · Computer Science 2025-09-08 Enric Boix-Adsera , Neil Mallinar , James B. Simon , Mikhail Belkin

Deep learning involves navigating a high-dimensional loss landscape over the neural network parameter space. Over the course of training, complex computational structures form and re-form inside the neural network, leading to shifts in…

Machine Learning · Computer Science 2025-08-04 Jesse Hoogland , George Wang , Matthew Farrugia-Roberts , Liam Carroll , Susan Wei , Daniel Murfet

Semantic segmentation of histopathology images under class imbalance is typically addressed through frequency-based loss reweighting, which implicitly assumes that rare classes are difficult. However, true difficulty also arises from…

Image and Video Processing · Electrical Eng. & Systems 2026-04-16 Lakmali Nadeesha Kumari , Sen-Ching Samson Cheung

The backpropagation algorithm, despite its widespread use in neural network learning, may not accurately emulate the human cortex's learning process. Alternative strategies, such as the Forward-Forward Algorithm (FFA), offer a closer match…

Neural and Evolutionary Computing · Computer Science 2023-05-23 Desmond Y. M. Tang