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Deep learning has facilitated the automation of radiotherapy by predicting accurate dose distribution maps. However, existing methods fail to derive the desirable radiotherapy parameters that can be directly input into the treatment…

Computer Vision and Pattern Recognition · Computer Science 2024-03-01 Jiaqi Cui , Yuanyuan Xu , Jianghong Xiao , Yuchen Fei , Jiliu Zhou , Xingcheng Peng , Yan Wang

Dose-Volume Histogram (DVH) prediction is fundamental in radiation therapy that facilitate treatment planning, dose evaluation, plan comparison and etc. It helps to increase the ability to deliver precise and effective radiation treatments…

Machine Learning · Computer Science 2024-02-05 Zehao Dong , Yixin Chen , Tianyu Zhao

In oncology, Positron Emission Tomography imaging is widely used in diagnostics of cancer metastases, in monitoring of progress in course of the cancer treatment, and in planning radiotherapeutic interventions. Accurate and reproducible…

Computer Vision and Pattern Recognition · Computer Science 2016-11-01 Jakub Czakon , Filip Drapejkowski , Grzegorz Zurek , Piotr Giedziun , Jacek Zebrowski , Witold Dyrka

Most radiotracers used in dynamic positron emission tomography (PET) scanning act in a linear time-invariant fashion so that the measured time-course data are a convolution between the time course of the tracer in the arterial supply and…

Current mainstream of CT reconstruction methods based on deep learning usually needs to fix the scanning geometry and dose level, which will significantly aggravate the training cost and need more training data for clinical application. In…

Medical Physics · Physics 2020-10-28 Wenjun Xia , Zexin Lu , Yongqiang Huang , Yan Liu , Hu Chen , Jiliu Zhou , Yi Zhang

Despite the ever-increasing interest in applying deep learning (DL) models to medical imaging, the typical scarcity and imbalance of medical datasets can severely impact the performance of DL models. The generation of synthetic data that…

Image and Video Processing · Electrical Eng. & Systems 2023-04-03 Pouria Rouzrokh , Bardia Khosravi , Shahriar Faghani , Mana Moassefi , Sanaz Vahdati , Bradley J. Erickson

Positron emission tomography (PET) is widely used in various clinical applications, including cancer diagnosis, heart disease and neuro disorders. The use of radioactive tracer in PET imaging raises concerns due to the risk of radiation…

Computer Vision and Pattern Recognition · Computer Science 2017-12-13 Junshen Xu , Enhao Gong , John Pauly , Greg Zaharchuk

Characterization of breast parenchyma on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a challenging task owing to the complexity of underlying tissue structures. Current quantitative approaches, including radiomics and…

Quantitative Methods · Quantitative Biology 2021-05-14 Fan Wang , Saarthak Kapse , Steven Liu , Prateek Prasanna , Chao Chen

Purpose: Various dose calculation algorithms are available for radiation therapy for cancer patients. However, these algorithms are faced with the tradeoff between efficiency and accuracy. The fast algorithms are generally less accurate,…

Medical Physics · Physics 2020-07-01 Yixun Xing , Dan Nguyen , Weiguo Lu , Ming Yang , Steve Jiang

Current clinical decision-making in oncology relies on averages of large patient populations to both assess tumor status and treatment outcomes. However, cancers exhibit an inherent evolving heterogeneity that requires an individual…

Deep learning has the potential to revolutionize medical practice by automating and performing important tasks like detecting and delineating the size and locations of cancers in medical images. However, most deep learning models rely on…

Image and Video Processing · Electrical Eng. & Systems 2023-11-28 Eirik A. Østmo , Kristoffer K. Wickstrøm , Keyur Radiya , Michael C. Kampffmeyer , Robert Jenssen

In radiotherapy, a trade-off exists between computational workload/speed and dose calculation accuracy. Calculation methods like pencil-beam convolution can be much faster than Monte-Carlo methods, but less accurate. The dose difference,…

Medical Physics · Physics 2020-05-18 Yixun Xing , Ph. D. , You Zhang , Ph. D. , Dan Nguyen , Ph. D. , Mu-Han Lin , Ph. D. , Weiguo Lu , Ph. D. , Steve Jiang , Ph. D

Positron Emission Tomography (PET) is a vital imaging modality widely used in clinical diagnosis and preclinical research but faces limitations in image resolution and signal-to-noise ratio due to inherent physical degradation factors.…

Image and Video Processing · Electrical Eng. & Systems 2024-11-11 Boxiao Yu , Kuang Gong

The application of deep learning to build accurate predictive models from functional neuroimaging data is often hindered by limited dataset sizes. Though data augmentation can help mitigate such training obstacles, most data augmentation…

Machine Learning · Computer Science 2019-10-21 Kevin P. Nguyen , Cherise Chin Fatt , Alex Treacher , Cooper Mellema , Madhukar H. Trivedi , Albert Montillo

The medical commissioning is an important step to bring a particle gantry into clinical operation for tumour treatments. This involves the parametrization and characterization of all relevant systems including the beam delivery, the patient…

Medical Physics · Physics 2018-04-25 David Meer

Artificial intelligence (AI)-based methods are showing substantial promise in segmenting oncologic positron emission tomography (PET) images. For clinical translation of these methods, assessing their performance on clinically relevant…

Medical Physics · Physics 2023-04-19 Ziping Liu , Joyce C. Mhlanga , Barry A. Siegel , Abhinav K. Jha

4D CT imaging is an essential component of radiotherapy of thoracic/abdominal tumors. 4D CT images are, however, often affected by artifacts that compromise treatment planning quality. In this work, deep learning (DL)-based conditional…

Medical Physics · Physics 2024-11-26 Frederic Madesta , Thilo Sentker , Tobias Gauer , Rene Werner

The purpose of this work is to develop viable procedures for verifying the applicability of personalized dosimetry in computed tomography (CT) using Monte Carlo-based simulations. Mobile equipment together with customized software was…

Background and Objectives: Predicting patient response to treatment and survival in oncology is a prominent way towards precision medicine. To that end, radiomics was proposed as a field of study where images are used instead of invasive…

Image and Video Processing · Electrical Eng. & Systems 2022-03-02 Amine Amyar , Romain Modzelewski , Pierre Vera , Vincent Morard , Su Ruan

Proton beam therapy has been developed to irradiate the tumor with higher precision and dose conformity compared to conventional X-ray irradiation. The dose conformity of this treatment modality may be further improved if narrower proton…