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Heterogeneity in efficacy is sometimes observed across baskets in basket trials. In this study, we propose a model-free clustering framework that groups baskets based on transition probabilities derived from the trajectories of treatment…

Methodology · Statistics 2026-01-05 Masahiro Kojima , Keisuke Hanada , Atsuya Sato

There is a keen interest in characterizing variation in the microbiome across cancer patients, given increasing evidence of its important role in determining treatment outcomes. Here our goal is to discover subgroups of patients with…

Applications · Statistics 2022-12-06 Yushu Shi , Liangliang Zhang , Kim-Anh Do , Robert Jenq , Christine Peterson

In many fields, researchers are interested in large and complex biological processes. Two important examples are gene expression and DNA methylation in genetics. One key problem is to identify aberrant patterns of these processes and…

Applications · Statistics 2012-10-03 Matthias Kormaksson , James G. Booth , Maria E. Figueroa , Ari Melnick

Clustering is an unsupervised learning method that constitutes a cornerstone of an intelligent data analysis process. It is used for the exploration of inter-relationships among a collection of patterns, by organizing them into homogeneous…

Machine Learning · Computer Science 2010-04-13 G. Nathiya , S. C. Punitha , M. Punithavalli

Getting a robust time-series clustering with best choice of distance measure and appropriate representation is always a challenge. We propose a novel mechanism to identify the clusters combining learned compact representation of…

Machine Learning · Computer Science 2021-01-12 Soma Bandyopadhyay , Anish Datta , Arpan Pal

Adapting machine learning algorithms to better handle the presence of clusters or batch effects within training datasets is important across a wide variety of biological applications. This article considers the effect of ensembling Random…

Machine Learning · Statistics 2025-04-01 Maya Ramchandran , Rajarshi Mukherjee , Giovanni Parmigiani

Causal effects are often characterized with population summaries. These might provide an incomplete picture when there are heterogeneous treatment effects across subgroups. Since the subgroup structure is typically unknown, it is more…

Methodology · Statistics 2026-04-07 Kwangho Kim , Jisu Kim , Edward H. Kennedy

Quality assessments of models in unsupervised learning and clustering verification in particular have been a long-standing problem in the machine learning research. The lack of robust and universally applicable cluster validity scores often…

Machine Learning · Statistics 2018-03-30 Luzie Helfmann , Johannes von Lindheim , Mattes Mollenhauer , Ralf Banisch

Drug repurposing has historically been an economically infeasible process for identifying novel uses for abandoned drugs. Modern machine learning has enabled the identification of complex biochemical intricacies in candidate drugs; however,…

Machine Learning · Computer Science 2025-09-16 Luke Delzer , Robert Kroleski , Ali K. AlShami , Jugal Kalita

We consider the problem of community detection or clustering in the labeled Stochastic Block Model (LSBM) with a finite number $K$ of clusters of sizes linearly growing with the global population of items $n$. Every pair of items is labeled…

Probability · Mathematics 2016-05-24 Se-Young Yun , Alexandre Proutiere

Matching identical products present in multiple product feeds constitutes a crucial element of many tasks of e-commerce, such as comparing product offerings, dynamic price optimization, and selecting the assortment personalized for the…

Databases · Computer Science 2024-02-16 Alicja Martinek , Szymon Łukasik , Amir H. Gandomi

Mixture models extend the toolbox of clustering methods available to the data analyst. They allow for an explicit definition of the cluster shapes and structure within a probabilistic framework and exploit estimation and inference…

Methodology · Statistics 2025-09-15 Bettina Grün

The problem of hierarchical clustering items from pairwise similarities is found across various scientific disciplines, from biology to networking. Often, applications of clustering techniques are limited by the cost of obtaining…

Machine Learning · Statistics 2012-07-20 Brian Eriksson

In this paper, we propose a regularized mixture probabilistic model to cluster matrix data and apply it to brain signals. The approach is able to capture the sparsity (low rank, small/zero values) of the original signals by introducing…

Methodology · Statistics 2018-08-07 Xu Gao , Weining Shen , Hernando Ombao

Recent works on Hierarchical Clustering (HC), a well-studied problem in exploratory data analysis, have focused on optimizing various objective functions for this problem under arbitrary similarity measures. In this paper we take the first…

Data Structures and Algorithms · Computer Science 2018-12-31 Moses Charikar , Vaggos Chatziafratis , Rad Niazadeh , Grigory Yaroslavtsev

Spectral clustering is a fast and popular algorithm for finding clusters in networks. Recently, Chaudhuri et al. (2012) and Amini et al.(2012) proposed inspired variations on the algorithm that artificially inflate the node degrees for…

Machine Learning · Statistics 2013-09-18 Tai Qin , Karl Rohe

Predicting the thermodynamic properties of mixtures is crucial for process design and optimization in chemical engineering. Machine learning (ML) methods are gaining increasing attention in this field, but experimental data for training are…

Machine Learning · Computer Science 2024-10-10 Dominik Gond , Jan-Tobias Sohns , Heike Leitte , Hans Hasse , Fabian Jirasek

Clustered data is ubiquitous in a variety of scientific fields. In this paper, we propose a flexible and interpretable modeling approach, called grouped heterogenous mixture modeling, for clustered data, which models cluster-wise…

Methodology · Statistics 2020-02-10 Shonosuke Sugasawa

Clustering is an important data mining technique where we will be interested in maximizing intracluster distance and also minimizing intercluster distance. We have utilized clustering techniques for detecting deviation in product sales and…

Databases · Computer Science 2013-12-11 S. Hanumanth Sastry , Prof. M. S. Prasada Babu

We propose a simple and efficient clustering method for high-dimensional data with a large number of clusters. Our algorithm achieves high-performance by evaluating distances of datapoints with a subset of the cluster centres. Our…

Machine Learning · Computer Science 2022-03-30 Georgios Exarchakis , Omar Oubari , Gregor Lenz
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