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In healthcare, it is essential to explain the decision-making process of machine learning models to establish the trustworthiness of clinicians. This paper introduces BI-RADS-Net, a novel explainable deep learning approach for cancer…

Computer Vision and Pattern Recognition · Computer Science 2021-10-11 Boyu Zhang , Aleksandar Vakanski , Min Xian

Correct classification of breast cancer sub-types is of high importance as it directly affects the therapeutic options. We focus on triple-negative breast cancer (TNBC) which has the worst prognosis among breast cancer types. Using cutting…

Applications · Statistics 2021-01-13 Pieter Segaert , Marta B. Lopes , Sandra Casimiro , Susana Vinga , Peter J. Rousseeuw

Precise breast cancer classification on histopathological images has the potential to greatly improve the diagnosis and patient outcome in oncology. The data imbalance problem largely stems from the inherent imbalance within medical image…

Image and Video Processing · Electrical Eng. & Systems 2024-11-28 Majid Behzadpour , Bengie L. Ortiz , Ebrahim Azizi , Kai Wu

Many common diseases have a complex genetic basis in which large numbers of genetic variations combine with environmental and lifestyle factors to determine risk. However, quantifying such polygenic effects and their relationship to disease…

In this work, we study and analyze different feature selection algorithms that can be used to classify cancer subtypes in case of highly varying high-dimensional data. We apply three different feature selection methods on five different…

Machine Learning · Computer Science 2021-10-01 Vaibhav Sinha , Siladitya Dash , Nazma Naskar , Sk Md Mosaddek Hossain

Current cancer screening guidelines cover only a few cancer types and rely on narrowly defined criteria such as age or a single risk factor like smoking history, to identify high-risk individuals. Predictive models using electronic health…

Machine Learning · Computer Science 2026-01-27 Jiheum Park , Chao Pang , Tristan Y. Lee , Jeong Yun Yang , Jacob Berkowitz , Alexander Z. Wei , Nicholas Tatonetti

Computational pathology is part of precision oncology medicine. The integration of high-throughput data including genomics, transcriptomics, proteomics, metabolomics, pathomics, and radiomics into clinical practice improves cancer treatment…

Image and Video Processing · Electrical Eng. & Systems 2022-06-07 Liangrui Pan , Zhichao Feng , Shaoliang Peng

We investigated the data-driven relationship between features in the tumor microenvironment (TME) and the overall and 5-year survival in triple-negative breast cancer (TNBC) and non-TNBC (NTNBC) patients by using Explainable Artificial…

A precise assessment of the risk of breast lesions can greatly lower it and assist physicians in choosing the best course of action. To categorise breast lesions, the majority of current computer-aided systems only use characteristics from…

Image and Video Processing · Electrical Eng. & Systems 2025-08-25 Muhaisin Tiyumba Nantogmah , Abdul-Barik Alhassan , Salamudeen Alhassan

Survival risk stratification is an important step in clinical decision making for breast cancer management. We propose a novel deep learning approach for this purpose by integrating histopathological imaging, genetic and clinical data. It…

Computer Vision and Pattern Recognition · Computer Science 2024-02-20 Raktim Kumar Mondol , Ewan K. A. Millar , Arcot Sowmya , Erik Meijering

Breast cancer is prevalent in Ethiopia that accounts 34% among women cancer patients. The diagnosis technique in Ethiopia is manual which was proven to be tedious, subjective, and challenging. Deep learning techniques are revolutionizing…

Computer Vision and Pattern Recognition · Computer Science 2020-08-20 Simon Hadush , Yaecob Girmay , Abiot Sinamo , Gebrekirstos Hagos

Breast cancer is the second leading cause of cancer-related death after lung cancer in women. Early detection of breast cancer in X-ray mammography is believed to have effectively reduced the mortality rate. However, a relatively high false…

Image and Video Processing · Electrical Eng. & Systems 2021-02-16 Xuejiao Tang , Liuhua Zhang , Wenbin Zhang , Xin Huang , Vasileios Iosifidis , Zhen Liu , Mingli Zhang , Enza Messina , Ji Zhang

Due to the heavy burden on medical institutes and computer-aided image diagnostics (CAD) have been gaining importance in diagnostic medicine to aid the medical staff to attain better service for the patients. Breast cancer is a fatal…

Quantitative Methods · Quantitative Biology 2023-03-24 Musaddiq Al Ali , Amjad Y. Sahib , Muazez Al Ali

Breast Cancer is the most common cancer among women, which is also visible in men, and accounts for more than 1 in 10 new cancer diagnoses each year. It is also the second most common cause of women who die from cancer. Hence, it…

Image and Video Processing · Electrical Eng. & Systems 2023-10-17 Kanan Mahammadli , Abdullah Burkan Bereketoglu , Ayse Gul Kabakci

Interval and large invasive breast cancers, which are associated with worse prognosis than other cancers, are usually detected at a late stage due to false negative assessments of screening mammograms. The missed screening-time detection is…

Computer Vision and Pattern Recognition · Computer Science 2025-12-16 Moein Sorkhei , Yue Liu , Hossein Azizpour , Edward Azavedo , Karin Dembrower , Dimitra Ntoula , Athanasios Zouzos , Fredrik Strand , Kevin Smith

Cardiotoxicity related to cancer therapies has become a serious issue, diminishing cancer treatment outcomes and quality of life. Early detection of cancer patients at risk for cardiotoxicity before cardiotoxic treatments and providing…

Quantitative Methods · Quantitative Biology 2020-05-21 Xi Yang , Yan Gong , Nida Waheed , Keith March , Jiang Bian , William R. Hogan , Yonghui Wu

Chronic diseases and cancer account for over 75 percent of healthcare costs in the US. Increased prevention services and improved primary care are thought to decrease costs. Current models for detecting changes in the health of populations…

Populations and Evolution · Quantitative Biology 2013-07-15 Jacob Kuriyan , Nathaniel Cobb

Breast cancer is one of the most common causes of cancer-related death in women worldwide. Early and accurate diagnosis of breast cancer may significantly increase the survival rate of patients. In this study, we aim to develop a fully…

Image and Video Processing · Electrical Eng. & Systems 2019-09-27 Sara Hosseinzadeh Kassani , Peyman Hosseinzadeh Kassani , Michal J. Wesolowski , Kevin A. Schneider , Ralph Deters

This research paper investigates the effectiveness of simple linear models versus complex machine learning techniques in breast cancer diagnosis, emphasizing the importance of interpretability and computational efficiency in the medical…

Machine Learning · Computer Science 2023-06-06 Muhammad Arbab Arshad , Sakib Shahriar , Khizar Anjum

Breast density classification is an essential part of breast cancer screening. Although a lot of prior work considered this problem as a task for learning algorithms, to our knowledge, all of them used small and not clinically realistic…

Computer Vision and Pattern Recognition · Computer Science 2017-11-13 Nan Wu , Krzysztof J. Geras , Yiqiu Shen , Jingyi Su , S. Gene Kim , Eric Kim , Stacey Wolfson , Linda Moy , Kyunghyun Cho