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In cryo-electron microscopy (EM), molecular structures are determined from large numbers of projection images of individual particles. To harness the full power of this single-molecule information, we use the Bayesian inference of EM…

Biomolecules · Quantitative Biology 2018-01-17 Pilar Cossio , David Rohr , Fabio Baruffa , Markus Rampp , Volker Lindenstruth , Gerhard Hummer

Modern neuroscience employs in silico experimentation on ever-increasing and more detailed neural networks. The high modelling detail goes hand in hand with the need for high model reproducibility, reusability and transparency. Besides, the…

Neurons and Cognition · Quantitative Biology 2022-05-25 Sotirios Panagiotou , Harry Sidiropoulos , Mario Negrello , Dimitrios Soudris , Christos Strydis

Mixture-of-Experts (MoE) models facilitate edge deployment by decoupling model capacity from active computation, yet their large memory footprint drives the need for GPU systems with near-data processing (NDP) capabilities that offload…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-01-08 Qi Wu , Chao Fang , Jiayuan Chen , Ye Lin , Yueqi Zhang , Yichuan Bai , Yuan Du , Li Du

High failure rates in cardiac drug development necessitate virtual clinical trials via electrocardiogram (ECG) generation to reduce risks and costs. However, existing ECG generation models struggle to balance morphological realism with…

Machine Learning · Computer Science 2026-03-31 Qian Shao , Bang Du , Zepeng Li , Qiyuan Chen , Jiahe Chen , Hongxia Xu , Jimeng Sun , Jian Wu , Jintai Chen

Emulator embedded neural networks, which are a type of physics informed neural network, leverage multi-fidelity data sources for efficient design exploration of aerospace engineering systems. Multiple realizations of the neural network…

Machine Learning · Computer Science 2023-09-14 Atticus Beachy , Harok Bae , Jose Camberos , Ramana Grandhi

Prevailing LLM serving engines employ expert parallelism (EP) to implement multi-device inference of massive MoE models. However, the efficiency of expert parallel inference is largely bounded by inter-device communication, as EP embraces…

Machine Learning · Computer Science 2026-03-02 Yan Li , Zhenyu Zhang , Zhengang Wang , Pengfei Chen , Pengfei Zheng

The family of Expectation-Maximization (EM) algorithms provides a general approach to fitting flexible models for large and complex data. The expectation (E) step of EM-type algorithms is time-consuming in massive data applications because…

Computation · Statistics 2018-06-21 Sanvesh Srivastava , Glen DePalma , Chuanhai Liu

From ancient philosophers to modern economists, biologists, and other researchers, there has been a continuous effort to unveil causal relations. The most formidable challenge lies in deducing the nature of the causal relationship: whether…

We introduce a rapid and precise analytical approach for analyzing cerebral blood flow (CBF) using Diffuse Correlation Spectroscopy (DCS) with the application of the Extreme Learning Machine (ELM). Our evaluation of ELM and existing…

Machine Learning · Computer Science 2024-02-02 Xi Chen , Zhenya Zang , Xingda Li

MEG/EEG are non-invasive imaging techniques that record brain activity with high temporal resolution. However, estimation of brain source currents from surface recordings requires solving an ill-posed inverse problem. Converging lines of…

Estimating the Individual Treatment Effect from observational data, defined as the difference between outcomes with and without treatment or intervention, while observing just one of both, is a challenging problems in causal learning. In…

Machine Learning · Computer Science 2020-05-07 Céline Beji , Michaël Bon , Florian Yger , Jamal Atif

Existing causal discovery methods based on combinatorial optimization or search are slow, prohibiting their application on large-scale datasets. In response, more recent methods attempt to address this limitation by formulating causal…

Machine Learning · Computer Science 2024-03-07 Victor Akinwande , J. Zico Kolter

Climate models, such as Earth system models (ESMs), are crucial for simulating future climate change based on projected Shared Socioeconomic Pathways (SSP) greenhouse gas emissions scenarios. While ESMs are sophisticated and invaluable,…

This paper presents a novel deep learning-based approach named RealDiffFusionNet incorporating Neural Controlled Differential Equations (Neural CDE) - time series models that are robust in handling irregularly sampled data - and multi-head…

Machine Learning · Computer Science 2025-01-07 Aashish Cheruvu , Nathaniel Rigoni

Empirical mode decomposition (EMD) has developed into a prominent tool for adaptive, scale-based signal analysis in various fields like robotics, security and biomedical engineering. Since the dramatic increase in amount of data puts…

Computer Vision and Pattern Recognition · Computer Science 2021-06-30 Jin Zhang , Fan Feng , Pere Marti-Puig , Cesar F. Caiafa , Zhe Sun , Feng Duan , Jordi Solé-Casals

Mixture-of-Experts is a promising approach for edge AI with low-batch inference. Yet, on-device deployments often face limited on-chip memory and severe workload imbalance; the prevalent use of offloading further incurs off-chip memory…

Hardware Architecture · Computer Science 2026-03-31 Songchen Ma , Hongyi Li , Weihao Zhang , Yonghao Tan , Pingcheng Dong , Yu Liu , Lan Liu , Yuzhong Jiao , Xuejiao Liu , Luhong Liang , Kwang-Ting Cheng

Effective connectivity analysis in functional magnetic resonance imaging (fMRI) studies directional interactions among brain regions and experimental stimuli. Dynamic causal modeling (DCM) is a widely used method to estimate effective…

Methodology · Statistics 2026-05-15 Kaitlyn R. Fales , Hyebin Song , Nicole A. Lazar

Dynamic Causal Modelling (DCM) is the predominant method for inferring effective connectivity from neuroimaging data. In the 15 years since its introduction, the neural models and statistical routines in DCM have developed in parallel,…

Quantitative Methods · Quantitative Biology 2019-07-15 Peter Zeidman , Amirhossein Jafarian , Nadège Corbin , Mohamed L. Seghier , Adeel Razi , Cathy J. Price , Karl J. Friston

Machine learning for scientific applications faces the challenge of limited data. We propose a framework that leverages a priori known physics to reduce overfitting when training on relatively small datasets. A deep neural network is…

Machine Learning · Computer Science 2019-11-22 Jonathan B. Freund , Jonathan F. MacArt , Justin Sirignano

We present a computational modeling framework for data-driven simulations and analysis of infectious disease spread in large populations. For the purpose of efficient simulations, we devise a parallel solution algorithm targeting…

Populations and Evolution · Quantitative Biology 2018-02-19 Pavol Bauer , Stefan Engblom , Stefan Widgren