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We prove existence and stability of solutions for a model of angiogenesis set in an annular region. Branching, anastomosis and extension of blood vessel tips are described by an integrodifferential kinetic equation of Fokker-Planck type…

Analysis of PDEs · Mathematics 2017-01-10 Ana Carpio , Gema Duro , Mihaela Negreanu

Tumor induced angiogenesis processes including the effect of stochastic motion and branching of blood vessels can be described coupling a (nonlocal in time) integrodifferential kinetic equation of Fokker-Planck type with a diffusion…

Analysis of PDEs · Mathematics 2016-12-30 Ana Carpio , Gema Duro

In this paper we design high-order positivity-preserving approximation schemes for an integro-differential model describing photochemical reactions. Specifically, we introduce and analyze three classes of dynamically consistent methods,…

Numerical Analysis · Mathematics 2025-07-31 Mario Pezzella

Ensemble averages of a stochastic model show that, after a formation stage, the tips of active blood vessels in an angiogenic network form a moving two dimensional stable diffusive soliton, which advances toward sources of growth factor.…

Statistical Mechanics · Physics 2020-08-26 L. L. Bonilla , M. Carretero , F. Terragni

In this work, we propose a positivity-preserving scheme for solving two-dimensional advection-diffusion equations including mixed derivative terms, in order to improve the accuracy of lower-order methods. The solution to these equations, in…

Computational Physics · Physics 2018-05-14 Erasmus J. du Toit , Martin R. O'Brien , Roddy G. L. Vann

In this paper, we introduce second order and fourth order space discretization via finite difference implementation of the finite element method for solving Fokker-Planck equations associated with irreversible processes. The proposed…

Numerical Analysis · Mathematics 2023-10-12 Chen Liu , Yuan Gao , Xiangxiong Zhang

Recently, numerical simulations of a stochastic model have shown that the density of vessel tips in tumor induced angiogenesis adopts a soliton-like profile [Sci. Rep. 6, 31296 (2016)]. In this work, we derive and solve the equations for…

Biological Physics · Physics 2017-01-02 L. L. Bonilla , M. Carretero , F. Terragni

In this work, we introduce semi-implicit or implicit finite difference schemes for the continuity equation with a gradient flow structure. Examples of such equations include the linear Fokker-Planck equation and the Keller-Segel equations.…

Numerical Analysis · Mathematics 2022-03-25 Jingwei Hu , Xiangxiong Zhang

In this paper, we are interested in constructing a scheme solving compressible Navier--Stokes equations, with desired properties including high order spatial accuracy, conservation, and positivity-preserving of density and internal energy…

Numerical Analysis · Mathematics 2023-09-13 Chen Liu , Xiangxiong Zhang

We study a system of particles in a two-dimensional geometry that move according to a reinforced random walk with transition probabilities dependent on the solutions of reaction-diffusion equations for the underlying fields. A birth process…

Tissues and Organs · Quantitative Biology 2021-04-02 L. L. Bonilla , M. Carretero , F. Terragni

We are interested in the high-order approximation of anisotropic, potential-driven advection-diffusion models on general polytopal partitions. We study two hybrid schemes, both built upon the Hybrid High-Order technology. The first one…

Numerical Analysis · Mathematics 2024-01-25 Simon Lemaire , Julien Moatti

In this paper, we develop a family of high order asymptotic preserving schemes for some discrete-velocity kinetic equations under a diffusive scaling, that in the asymptotic limit lead to macroscopic models such as the heat equation, the…

Numerical Analysis · Mathematics 2013-06-04 Juhi Jang , Fengyan Li , Jing-Mei Qiu , Tao Xiong

We introduce a nonlinear structure preserving high-order scheme for anisotropic advection-diffusion equations. This scheme, based on Hybrid High-Order methods, can handle general meshes. It also has an entropy structure, and preserves the…

Numerical Analysis · Mathematics 2023-10-20 Julien Moatti

For high-order accurate schemes such as discontinuous Galerkin (DG) methods solving Fokker-Planck equations, it is desired to efficiently enforce positivity without losing conservation and high-order accuracy, especially for implicit time…

Numerical Analysis · Mathematics 2025-05-16 Chen Liu , Jingwei Hu , William T. Taitano , Xiangxiong Zhang

In this paper, we derive two bound-preserving and mass-conserving schemes based on the fractional-step method and high-order compact (HOC) finite difference method for nonlinear convection-dominated diffusion equations. We split the…

Numerical Analysis · Mathematics 2024-09-16 Baolin Kuang , Hongfei Fu , Shusen Xie

We propose a high order discontinuous Galerkin (DG) method for solving nonlinear Fokker-Planck equations with a gradient flow structure. For some of these models it is known that the transient solutions converge to steady-states when time…

Numerical Analysis · Mathematics 2016-01-12 Hailiang Liu , Zhongming Wang

We propose fully discrete, implicit-in-time finite-volume schemes for a general family of non-linear and non-local Fokker-Planck equations with a gradient-flow structure, usually known as aggregation-diffusion equations, in any dimension.…

Numerical Analysis · Mathematics 2020-09-29 Rafael Bailo , Jose A. Carrillo , Jingwei Hu

Angiogenesis is a multiscale process by which a primary blood vessel issues secondary vessel sprouts that reach regions lacking oxygen. Angiogenesis can be a natural process of organ growth and development or a pathological induced by a…

Analysis of PDEs · Mathematics 2022-10-28 Björn Birnir , Luis Bonilla , Manuel Carretero , Filippo Terragni

A coupled system of nonlinear mixed-type equations modeling early stages of angiogenesis is analyzed in a bounded domain. The system consists of stochastic differential equations describing the movement of the positions of the tip and stalk…

Analysis of PDEs · Mathematics 2022-06-24 Markus Fellner , Ansgar Jüngel

We prove existence and uniqueness of nonnegative solutions for a nonlocal in time integrodifferential diffusion system related to angiogenesis descriptions. Fundamental solutions of appropriately chosen parabolic operators with bounded…

Analysis of PDEs · Mathematics 2016-12-30 Ana Carpio , Gema Duro
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