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A new approach to adaptive design of clinical trials is proposed in a general multiparameter exponential family setting, based on generalized likelihood ratio statistics and optimal sequential testing theory. These designs are easy to…

Statistics Theory · Mathematics 2011-05-25 Jay Bartroff , Tze Leung Lai

Designing networks capable of attaining better performance with an increased inference budget is important to facilitate generalization to harder problem instances. Recent efforts have shown promising results in this direction by making use…

Machine Learning · Computer Science 2022-11-21 Cem Anil , Ashwini Pokle , Kaiqu Liang , Johannes Treutlein , Yuhuai Wu , Shaojie Bai , Zico Kolter , Roger Grosse

Given large datasets and sufficient compute, is it beneficial to design neural architectures for the structure and symmetries of each problem? Or is it more efficient to learn them from data? We study empirically how equivariant and…

Machine Learning · Computer Science 2025-07-29 Johann Brehmer , Sönke Behrends , Pim de Haan , Taco Cohen

(2+1) dimensional diffusion equation is considered within the framework of equivalence transformations. Generators for the group are obtained and admissible transformations between linear and nonlinear equations are examined. It is shown…

Mathematical Physics · Physics 2025-07-24 Saadet Özer

The properties of the normal distribution under linear transformation, as well the easy way to compute the covariance matrix of marginals and conditionals, offer a unique opportunity to get an insight about several aspects of uncertainties…

Data Analysis, Statistics and Probability · Physics 2018-02-12 Giulio D'Agostini

We consider the invariant measure of homogeneous random walks in the quarter-plane. In particular, we consider measures that can be expressed as a finite linear combination of geometric terms and present conditions on the structure of these…

Probability · Mathematics 2014-07-02 Yanting Chen , Richard J. Boucherie , Jasper Goseling

Designing a covariance function that represents the underlying correlation is a crucial step in modeling complex natural systems, such as climate models. Geospatial datasets at a global scale usually suffer from non-stationarity and…

Machine Learning · Statistics 2015-07-10 Chintan A. Dalal , Vladimir Pavlovic , Robert E. Kopp

Diffusion probabilistic models (DPMs) are a class of powerful deep generative models (DGMs). Despite their success, the iterative generation process over the full timesteps is much less efficient than other DGMs such as GANs. Thus, the…

Machine Learning · Computer Science 2022-06-16 Fan Bao , Chongxuan Li , Jiacheng Sun , Jun Zhu , Bo Zhang

This paper traces the strong relations between experimental design and control, such as the use of optimal inputs to obtain precise parameter estimation in dynamical systems and the introduction of suitably designed perturbations in…

Optimization and Control · Mathematics 2008-03-03 Luc Pronzato

A novel general framework for the study of $\Gamma$-convergence of functionals defined over pairs of measures and energy-measures is introduced. This theory allows us to identify the $\Gamma$-limit of these kind of functionals by knowing…

Analysis of PDEs · Mathematics 2020-04-22 Marco Caroccia , Riccardo Cristoferi

A common problem in Phase II clinical trials is the comparison of dose response curves corresponding to different treatment groups. If the effect of the dose level is described by parametric regression models and the treatments differ in…

Statistics Theory · Mathematics 2016-03-16 Chrystel Feller , Kirsten Schorning , Holger Dette , Georgina Bermann , Björn Bornkamp

Systems with both quantitative and qualitative responses are widely encountered in many applications. Design of experiment methods are needed when experiments are conducted to study such systems. Classic experimental design methods are…

Methodology · Statistics 2023-04-24 Lulu Kang , Xinwei Deng , Ran Jin

Global quantum sensing enables parameter estimation across arbitrary ranges with a finite number of measurements. Among the various existing formulations, the Bayesian paradigm stands as a flexible approach for optimal protocol design under…

This article introduces a novel nonparametric methodology for Generalized Linear Models which combines the strengths of the binary regression and latent variable formulations for categorical data, while overcoming their disadvantages.…

Machine Learning · Statistics 2021-10-12 K. P. Chowdhury

Graph machine learning architectures are typically tailored to specific tasks on specific datasets, which hinders their broader applicability. This has led to a new quest in graph machine learning: how to build graph foundation models…

Machine Learning · Computer Science 2025-10-29 Ben Finkelshtein , İsmail İlkan Ceylan , Michael Bronstein , Ron Levie

In this paper, we consider the multicollinearity problem in the gamma regression model when model parameters are linearly restricted. The linear restrictions are available from prior information to ensure the validity of scientific theories…

Methodology · Statistics 2023-03-10 Solmaz Seifollahi , Hossein Bevrani , Kaniav Kamary

We consider experiments for comparing treatments using units that are ordered linearly over time or space within blocks. In addition to the block effect, we assume that a trend effect influences the response. The latter is modeled as a…

Statistics Theory · Mathematics 2008-12-18 Dibyen Majumdar , John Stufken

Statistical inference on the explained variation of an outcome by a set of covariates is of particular interest in practice. When the covariates are of moderate to high-dimension and the effects are not sparse, several approaches have been…

Methodology · Statistics 2022-01-24 Hua Yun Chen

Exploiting symmetry in dynamical systems is a powerful way to improve the generalization of deep learning. The model learns to be invariant to transformation and hence is more robust to distribution shift. Data augmentation and equivariant…

Machine Learning · Computer Science 2022-06-22 Rui Wang , Robin Walters , Rose Yu

A connection between the General Linear Model (GLM) in combination with classical statistical inference and the machine learning (MLE)-based inference is described in this paper. Firstly, the estimation of the GLM parameters is expressed as…

Machine Learning · Statistics 2022-02-10 Juan Manuel Gorriz , SIPBA group , John Suckling