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Analysis of three-dimensional biological samples is critical to understanding tissue function and the mechanisms of disease. Many chronic conditions, like neurodegenerative diseases and cancers, correlate with complex tissue changes that…

Biological Physics · Physics 2019-11-06 Jiaming Guo , Camille Artur , Jason L. Eriksen , David Mayerich

To extract liver from medical images is a challenging task due to similar intensity values of liver with adjacent organs, various contrast levels, various noise associated with medical images and irregular shape of liver. To address these…

Image and Video Processing · Electrical Eng. & Systems 2021-03-29 Muhammad Islam , Kaleem Nawaz Khan , Muhammad Salman Khan

We develop a physiologically-based lattice model for the transport and metabolism of drugs in the functional unit of the liver, called the lobule. In contrast to earlier studies, we have emphasized the dominant role of convection in…

Biological Physics · Physics 2011-11-07 Vahid Rezania , Rebeccah E. Marsh , Dennis Coombe , Jack A. Tuszynski

The visual analysis of retina and of its vascular characteristics is important in the diagnosis and monitoring of diseases of visual perception. In the related medical diagnoses, the digital processing of the fundus images is used to obtain…

Computer Vision and Pattern Recognition · Computer Science 2015-08-06 Amelia Carolina Sparavigna

Lipid droplets (LDs), once considered mere storage depots for lipids, have gained recognition for their intricate roles in cellular processes, including metabolism, membrane trafficking, and disease states like obesity and cancer. This…

Biological Physics · Physics 2023-10-26 Hyeonwoo Kim , Seungeun Oh , Seongsoo Lee , Kwang suk Lee , YongKeun Park

With the increase in the use of deep learning for computer-aided diagnosis in medical images, the criticism of the black-box nature of the deep learning models is also on the rise. The medical community needs interpretable models for both…

Image and Video Processing · Electrical Eng. & Systems 2020-12-21 Mookund Sureka , Abhijeet Patil , Deepak Anand , Amit Sethi

It is critically important to detect the content of liver fat as it is related to cardiac complications and cardiovascular disease mortality. However, existing methods are either associated with high cost and/or medical complications (e.g.,…

Image and Video Processing · Electrical Eng. & Systems 2024-06-03 Qiyue Wang , Wu Xue , Xiaoke Zhang , Fang Jin , James Hahn

Global eradication of malaria depends on the development of drugs effective against the silent, yet obligate liver stage of the disease. The gold standard in drug development remains microscopic imaging of liver stage parasites in in vitro…

Quantitative Methods · Quantitative Biology 2019-12-03 Ava P. Soleimany , Harini Suresh , Jose Javier Gonzalez Ortiz , Divya Shanmugam , Nil Gural , John Guttag , Sangeeta N. Bhatia

Histopathological assessments, including surgical resection and core needle biopsy, are the standard procedures in the diagnosis of the prostate cancer. Current interpretation of the histopathology images includes the determination of the…

Computer Vision and Pattern Recognition · Computer Science 2017-05-12 Naiyun Zhou , Andrey Fedorov , Fiona Fennessy , Ron Kikinis , Yi Gao

Liver tumor segmentation and classification are important tasks in computer aided diagnosis. We aim to address three problems: liver tumor screening and preliminary diagnosis in non-contrast computed tomography (CT), and differential…

Image and Video Processing · Electrical Eng. & Systems 2023-10-24 Ke Yan , Xiaoli Yin , Yingda Xia , Fakai Wang , Shu Wang , Yuan Gao , Jiawen Yao , Chunli Li , Xiaoyu Bai , Jingren Zhou , Ling Zhang , Le Lu , Yu Shi

This paper addresses the problem of liver cancer segmentation in Whole Slide Image (WSI). We propose a multi-scale image processing method based on automatic end-to-end deep neural network algorithm for segmentation of cancer area. A…

Image and Video Processing · Electrical Eng. & Systems 2020-07-29 Yanbo Feng , Adel Hafiane , Hélène Laurent

The early detection, diagnosis and monitoring of liver cancer progression can be achieved with the precise delineation of metastatic tumours. However, accurate automated segmentation remains challenging due to the presence of noise,…

Machine Learning · Computer Science 2015-09-02 Samuel Kadoury , Eugene Vorontsov , An Tang

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, and the most common cause of death of people suffering from cirrhosis. The segmentation of liver lesions in CT images allows assessment of tumor load,…

Computer Vision and Pattern Recognition · Computer Science 2020-03-16 Nadja Gruber , Stephan Antholzer , Werner Jaschke , Christian Kremser , Markus Haltmeier

With the success of deep learning-based methods applied in medical image analysis, convolutional neural networks (CNNs) have been investigated for classifying liver disease from ultrasound (US) data. However, the scarcity of available…

Image and Video Processing · Electrical Eng. & Systems 2021-12-21 Hui Che , Sumana Ramanathan , David Foran , John L Nosher , Vishal M Patel , Ilker Hacihaliloglu

Currently, diagnostic medicine uses a multitude of tools ranging from ionising radiation to histology analysis. With advances in piezoelectric crystal technology, high-frequency ultrasound imaging has developed to achieve comparatively high…

Medical Physics · Physics 2022-01-13 Akhil Kallepalli , James Halls , David B. James , Mark A. Richardson

Histopathological image analysis is a reliable method for prostate cancer identification. In this paper, we present a comparative analysis of two approaches for segmenting glandular structures in prostate images to automate Gleason grading.…

Image and Video Processing · Electrical Eng. & Systems 2025-01-23 Feda Bolus Al Baqain , Omar Sultan Al-Kadi

Hepatic vessels in computed tomography scans often suffer from image fragmentation and noise interference, making it difficult to maintain vessel integrity and posing significant challenges for vessel segmentation. To address this issue, we…

Image and Video Processing · Electrical Eng. & Systems 2025-01-03 Shengbo Tan , Rundong Xue , Shipeng Luo , Zeyu Zhang , Xinran Wang , Lei Zhang , Daji Ergu , Zhang Yi , Yang Zhao , Ying Cai

Anatomical segmentation of organs in ultrasound images is essential to many clinical applications, particularly for diagnosis and monitoring. Existing deep neural networks require a large amount of labeled data for training in order to…

Image and Video Processing · Electrical Eng. & Systems 2023-08-01 Yordanka Velikova , Mohammad Farid Azampour , Walter Simson , Vanessa Gonzalez Duque , Nassir Navab

Histopathology images; microscopy images of stained tissue biopsies contain fundamental prognostic information that forms the foundation of pathological analysis and diagnostic medicine. However, diagnostics from histopathology images…

Computer Vision and Pattern Recognition · Computer Science 2019-10-30 Aïcha BenTaieb , Ghassan Hamarneh

One of the most effective ways to treat liver cancer is to perform precise liver resection surgery, the key step of which includes precise digital image segmentation of the liver and its tumor. However, traditional liver parenchymal…

Other Quantitative Biology · Quantitative Biology 2024-06-11 Danyi Huang , Ziang Liu , Yizhou Li