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Modern high-throughput biomedical devices routinely produce data on a large scale, and the analysis of high-dimensional datasets has become commonplace in biomedical studies. However, given thousands or tens of thousands of measured…

Methodology · Statistics 2022-02-28 Vladimir Vutov , Thorsten Dickhaus

Motivated by the latest effort to employ banded matrices to estimate a high-dimensional covariance $\Sigma$, we propose a test for $\Sigma$ being banded with possible diverging bandwidth. The test is adaptive to the "large $p$, small $n$"…

Statistics Theory · Mathematics 2012-08-17 Yumou Qiu , Song Xi Chen

Robust estimation is much more challenging in high dimensions than it is in one dimension: Most techniques either lead to intractable optimization problems or estimators that can tolerate only a tiny fraction of errors. Recent work in…

Machine Learning · Computer Science 2018-03-14 Ilias Diakonikolas , Gautam Kamath , Daniel M. Kane , Jerry Li , Ankur Moitra , Alistair Stewart

A precision matrix is the inverse of a covariance matrix. In this paper, we study the problem of estimating the precision matrix with a known graphical structure under high-dimensional settings. We propose a simple estimator of the…

Statistics Theory · Mathematics 2021-07-15 Thien-Minh Le , Ping-Shou Zhong

We study the problem of testing the covariance matrix of a high-dimensional Gaussian in a robust setting, where the input distribution has been corrupted in Huber's contamination model. Specifically, we are given i.i.d. samples from a…

Machine Learning · Computer Science 2021-01-01 Ilias Diakonikolas , Daniel M. Kane

We propose a general framework for nonasymptotic covariance matrix estimation making use of concentration inequality-based confidence sets. We specify this framework for the estimation of large sparse covariance matrices through…

Methodology · Statistics 2020-12-17 Adam B Kashlak , Linglong Kong

Unraveling the co-expression of genes across studies enhances the understanding of cellular processes. Inferring gene co-expression networks from transcriptome data presents many challenges, including spurious gene correlations, sample…

Machine Learning · Statistics 2024-10-01 Teodora Pandeva , Martijs Jonker , Leendert Hamoen , Joris Mooij , Patrick Forré

We propose a high dimensional mean test framework for shrinking random variables, where the underlying random variables shrink to zero as the sample size increases. By pooling observations across overlapping subsets of dimensions, we…

Methodology · Statistics 2026-02-11 Liujun Chen , Chen Zhou

Many genomic experiments, notably microarray experiments seeking to detect differential gene expression, involve calculating a large number of p-values. This leads to the multiple testing problem: when the number of null hypotheses is…

Quantitative Methods · Quantitative Biology 2007-05-23 David R. Bickel

We consider the problem of estimating high-dimensional covariance matrices of $K$-populations or classes in the setting where the sample sizes are comparable to the data dimension. We propose estimating each class covariance matrix as a…

Methodology · Statistics 2022-02-08 Elias Raninen , David E. Tyler , Esa Ollila

In biomedical studies, testing for differences in covariance offers scientific insights beyond mean differences, especially when differences are driven by complex joint behavior between features. However, when differences in joint behavior…

Methodology · Statistics 2026-04-07 David Veitch , Yinqiu He , Jun Young Park

Thanks to its favorable properties, the multivariate normal distribution is still largely employed for modeling phenomena in various scientific fields. However, when the number of components $p$ is of the same asymptotic order as the sample…

Statistics Theory · Mathematics 2022-11-17 Caizhu Huang , Claudia Di Caterina , Nicola Sartori

The use of M-estimators in generalized linear regression models in high dimensional settings requires risk minimization with hard $L_0$ constraints. Of the known methods, the class of projected gradient descent (also known as iterative hard…

Machine Learning · Computer Science 2014-10-22 Prateek Jain , Ambuj Tewari , Purushottam Kar

The spectral density matrix is a fundamental object of interest in time series analysis, and it encodes both contemporary and dynamic linear relationships between component processes of the multivariate system. In this paper we develop…

Statistics Theory · Mathematics 2025-02-04 Jinyuan Chang , Qing Jiang , Tucker S. McElroy , Xiaofeng Shao

High-dimensional compositional data arise naturally in many applications such as metagenomic data analysis. The observed data lie in a high-dimensional simplex, and conventional statistical methods often fail to produce sensible results due…

Methodology · Statistics 2016-01-19 Yuanpei Cao , Wei Lin , Hongzhe Li

Standard statistical methods that do not take proper account of the complexity of survey design can lead to erroneous inferences when applied to survey data due to unequal selection probabilities, clustering, and other design features. In…

Methodology · Statistics 2021-03-04 Jae-kwang Kim , J. N. K. Rao , Zhonglei Wang

Random Projection (RP) technique has been widely applied in many scenarios because it can reduce high-dimensional features into low-dimensional space within short time and meet the need of real-time analysis of massive data. There is an…

Machine Learning · Computer Science 2017-06-20 Haozhe Xie , Jie Li , Qiaosheng Zhang , Yadong Wang

We consider the problem of large-scale inference on the row or column variables of data in the form of a matrix. Often this data is transposable, meaning that both the row variables and column variables are of potential interest. An example…

Methodology · Statistics 2015-03-13 Genevera I. Allen , Robert Tibshirani

This paper studies the inference of the regression coefficient matrix under multivariate response linear regressions in the presence of hidden variables. A novel procedure for constructing confidence intervals of entries of the coefficient…

Methodology · Statistics 2022-01-21 Xin Bing , Wei Cheng , Huijie Feng , Yang Ning

In this paper we consider testing the equality of probability vectors of two independent multinomial distributions in high dimension. The classical chi-square test may have some drawbacks in this case since many of cell counts may be zero…

Statistics Theory · Mathematics 2017-11-16 Amanda Plunkett , Junyong Park