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In neuroimaging analysis, fMRI can well assess the function changes for brain diseases with no obvious structural lesions. To date, most deep-learning-based fMRI studies have employed functional connectivity (FC) as the basic feature for…

Image and Video Processing · Electrical Eng. & Systems 2023-03-03 Wei Dai , Ziyao Zhang , Lixia Tian , Shengyuan Yu , Shuhui Wang , Zhao Dong , Hairong Zheng

Structural and functional neuroimaging modalities provide complementary windows into brain organization: structural imaging characterizes neural tissue anatomy and microstructure, while functional imaging captures dynamic patterns of neural…

Methodology · Statistics 2026-03-24 Sakul Mahat , Sharmistha Guha , Jessica Bernard

Currently, the diagnosis of Autism Spectrum Disorder (ASD) is dependent upon a subjective, time-consuming evaluation of behavioral tests by an expert clinician. Non-invasive functional MRI (fMRI) characterizes brain connectivity and may be…

Machine Learning · Computer Science 2020-05-26 Cooper J. Mellema , Alex Treacher , Kevin P. Nguyen , Albert Montillo

Functional magnetic resonance imaging (fMRI) has provided invaluable insight into our understanding of human behavior. However, large inter-individual differences in both brain anatomy and functional localization after anatomical alignment…

Applications · Statistics 2021-11-03 Guoqing Wang , Abhirup Datta , Martin A. Lindquist

Studies in recent years have demonstrated that neural organization and structure impact an individual's ability to perform a given task. Specifically, individuals with greater neural efficiency have been shown to outperform those with less…

Resting-state functional magnetic resonance imaging (rs-fMRI) can reflect spontaneous neural activities in brain and is widely used for brain disorder analysis.Previous studies propose to extract fMRI representations through diverse…

Quantitative Methods · Quantitative Biology 2023-06-27 Qianqian Wang , Wei Wang , Yuqi Fang , P. -T. Yap , Hongtu Zhu , Hong-Jun Li , Lishan Qiao , Mingxia Liu

Recent studies on analyzing dynamic brain connectivity rely on sliding-window analysis or time-varying coefficient models which are unable to capture both smooth and abrupt changes simultaneously. Emerging evidence suggests state-related…

Applications · Statistics 2019-07-04 Chee-Ming Ting , Hernando Ombao , S. Balqis Samdin , Sh-Hussain Salleh

Over the past decade, studies of naturalistic language processing where participants are scanned while listening to continuous text have flourished. Using word embeddings at first, then large language models, researchers have created…

Computation and Language · Computer Science 2024-11-05 Laurent Bonnasse-Gahot , Christophe Pallier

Brain aging, and more specifically the difference between the chronological and the biological age of a person, may be a promising biomarker for identifying neurodegenerative diseases. For this purpose accurate prediction is important but…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Kyriaki-Margarita Bintsi , Vasileios Baltatzis , Alexander Hammers , Daniel Rueckert

Knowing brain connectivity is of great importance both in basic research and for clinical applications. We are proposing a method to infer directed connectivity from zero-lag covariances of neuronal activity recorded at multiple sites. This…

Neurons and Cognition · Quantitative Biology 2018-04-10 Jonathan Schiefer , Alexander Niederbühl , Volker Pernice , Carolin Lennartz , Pierre LeVan , Jürgen Henning , Stefan Rotter

Background: Functional magnetic resonance imaging (fMRI) provides non-invasive measures of neuronal activity using an endogenous Blood Oxygenation-Level Dependent (BOLD) contrast. This article introduces a nonlinear dimensionality reduction…

Image and Video Processing · Electrical Eng. & Systems 2019-12-09 Gagan Sidhu

In this work we focus on examination and comparison of whole-brain functional connectivity patterns measured with fMRI across experimental conditions. Direct examination and comparison of condition-specific matrices is challenging due to…

Applications · Statistics 2013-01-02 Svetlana V. Shinkareva , Vladimir Gudkov , Jing Wang

Task-based functional magnetic resonance imaging (task fMRI) is a non-invasive technique that allows identifying brain regions whose activity changes when individuals are asked to perform a given task. This contributes to the understanding…

With the increased need for multi-center magnetic resonance imaging studies, problems arise related to differences in hardware and software between centers. Namely, current algorithms for brain volume quantification are unreliable for the…

Image and Video Processing · Electrical Eng. & Systems 2019-11-12 Maria Ines Meyer , Ezequiel de la Rosa , Koen Van Leemput , Diana M. Sima

Studies of functional MRI data are increasingly concerned with the estimation of differences in spatio-temporal networks across groups of subjects or experimental conditions. Unsupervised clustering and independent component analysis (ICA)…

The brain's structural connectome supports signal propagation between neuronal elements, shaping diverse coactivation patterns that can be captured as functional connectivity. While the link between structure and function remains an ongoing…

Neurons and Cognition · Quantitative Biology 2022-07-11 Yaqian Yang , Zhiming Zheng , Longzhao Liu , Hongwei Zheng , Yi Zhen , Yi Zheng , Xin Wang , Shaoting Tang

Brain connectome analysis commonly compresses high-resolution brain scans (typically composed of millions of voxels) down to only hundreds of regions of interest (ROIs) by averaging within-ROI signals. This huge dimension reduction improves…

Methodology · Statistics 2025-03-25 Tong Lu , Yuan Zhang , Peter Kochunov , Elliot Hong , Shuo Chen

Evaluating the causal effect of an intervention on multivariate outcomes is challenging when the outcomes are interdependent and derived rather than directly observed. Effective connectivity, which summarizes the directional neural…

Methodology · Statistics 2026-04-02 Haiyue Song , Ani Eloyan , Youjin Lee

The field of neuroimaging has truly become data rich, and novel analytical methods capable of gleaning meaningful information from large stores of imaging data are in high demand. Those methods that might also be applicable on the level of…

The dispute of how the human brain represents conceptual knowledge has been argued in many scientific fields. Brain imaging studies have shown that the spatial patterns of neural activation in the brain are correlated with thinking about…

Neurons and Cognition · Quantitative Biology 2018-06-15 Subba Reddy Oota , Naresh Manwani , Bapi Raju S