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The growing adoption of electronic health record (EHR) systems has provided unprecedented opportunities for predictive modeling to guide clinical decision making. Structured EHRs contain longitudinal observations of patients across hospital…

Machine Learning · Computer Science 2026-03-12 Deyi Li , Zijun Yao , Qi Xu , Muxuan Liang , Lingyao Li , Zijian Xu , Mei Liu

Foundation models (FMs) trained on electronic health records (EHRs) have shown strong performance on a range of clinical prediction tasks. However, adapting these models to local health systems remains challenging due to limited data…

For most problems in science and engineering we can obtain data sets that describe the observed system from various perspectives and record the behavior of its individual components. Heterogeneous data sets can be collectively mined by data…

Machine Learning · Computer Science 2015-02-09 Marinka Žitnik , Blaž Zupan

The growing availability of well-organized Electronic Health Records (EHR) data has enabled the development of various machine learning models towards disease risk prediction. However, existing risk prediction methods overlook the…

Machine Learning · Computer Science 2024-06-17 Ziyang Zhang , Hejie Cui , Ran Xu , Yuzhang Xie , Joyce C. Ho , Carl Yang

Modeling continuous-time physiological processes that manifest a patient's evolving clinical states is a key step in approaching many problems in healthcare. In this paper, we develop the Hidden Absorbing Semi-Markov Model (HASMM): a…

Artificial Intelligence · Computer Science 2016-12-28 Ahmed M. Alaa , Mihaela van der Schaar

Electronic health record (EHR) data is sparse and irregular as it is recorded at irregular time intervals, and different clinical variables are measured at each observation point. In this work, we propose a multi-view features integration…

Machine Learning · Computer Science 2021-01-27 Yurim Lee , Eunji Jun , Heung-Il Suk

Supervised cross-modal hashing has gained increasing research interest on large-scale retrieval task owning to its satisfactory performance and efficiency. However, it still has some challenging issues to be further studied: 1) most of them…

Machine Learning · Computer Science 2019-05-07 Tao Yao , Xiangwei Kong , Lianshan Yan , Wenjing Tang , Qi Tian

This study proposes a Transformer-based longitudinal modeling method to address challenges in clinical risk classification with heterogeneous Electronic Health Record (EHR) data, including irregular temporal patterns, large modality…

Machine Learning · Computer Science 2025-11-07 Anzhuo Xie , Wei-Chen Chang

We introduce HTAD, a novel model for diagnosis prediction using Electronic Health Records (EHR) represented as Heterogeneous Information Networks. Recent studies on modeling EHR have shown success in automatically learning representations…

Machine Learning · Computer Science 2019-12-24 Anahita Hosseini , Tyler Davis , Majid Sarrafzadeh

Cancer arises from successive rounds of mutations which generate tumor cells with different genomic variation i.e. clones. For drug responsiveness and therapeutics, it is necessary to identify the clones in tumor sample accurately. Many…

Genomics · Quantitative Biology 2015-03-03 Gholamreza Haffari , Zhaoxiang Cai , Mohammad S. Rahman , Ann E. Nicholson

Multimodal sentiment analysis remains a challenging task due to the inherent heterogeneity across modalities. Such heterogeneity often manifests as asynchronous signals, imbalanced information between modalities, and interference from…

Multimedia · Computer Science 2025-11-26 Yadong Liu , Shangfei Wang

Due to patient privacy protection concerns, machine learning research in healthcare has been undeniably slower and limited than in other application domains. High-quality, realistic, synthetic electronic health records (EHRs) can be…

Machine Learning · Computer Science 2023-02-10 Huan He , Shifan Zhao , Yuanzhe Xi , Joyce C Ho

With large volumes of health care data comes the research area of computational phenotyping, making use of techniques such as machine learning to describe illnesses and other clinical concepts from the data itself. The "traditional"…

Machine Learning · Statistics 2016-12-30 Chris Hodapp

Evaluating the clinical similarities between pairwise patients is a fundamental problem in healthcare informatics. A proper patient similarity measure enables various downstream applications, such as cohort study and treatment comparative…

Machine Learning · Statistics 2019-02-12 Zihao Zhu , Changchang Yin , Buyue Qian , Yu Cheng , Jishang Wei , Fei Wang

In the dynamic hospital setting, decision support can be a valuable tool for improving patient outcomes. Data-driven inference of future outcomes is challenging in this dynamic setting, where long sequences such as laboratory tests and…

Quantitative Methods · Quantitative Biology 2024-04-25 Alan D. Kaplan , Priyadip Ray , John D. Greene , Vincent X. Liu

The availability of large and deep electronic healthcare records (EHR) datasets has the potential to enable a better understanding of real-world patient journeys, and to identify novel subgroups of patients. ML-based aggregation of EHR data…

Machine Learning · Computer Science 2022-08-03 Owen Parsons , Nathan E Barlow , Janie Baxter , Karen Paraschin , Andrea Derix , Peter Hein , Robert Dürichen

Longitudinal electronic health record (EHR) data offer opportunities to study biomarker trajectories; however, association estimates-the primary inferential target-from standard models designed for regular observation times may be biased by…

Methodology · Statistics 2026-02-18 Cheng-Han Yang , Xu Shi , Bhramar Mukherjee

Quality-of-service (QoS) data exhibit dynamic temporal patterns that are crucial for accurately predicting missing values. These patterns arise from the evolving interactions between users and services, making it essential to capture the…

Machine Learning · Computer Science 2025-03-05 Yikai Hou , Peng Tang

Electronic Health Record (EHR) data encompass diverse modalities -- text, images, and medical codes -- that are vital for clinical decision-making. To process these complex data, multimodal AI (MAI) has emerged as a powerful approach for…

Machine Learning · Computer Science 2026-03-03 Nikkie Hooman , Zhongjie Wu , Eric C. Larson , Mehak Gupta

Phenotyping consists in applying algorithms to identify individuals associated with a specific, potentially complex, trait or condition, typically out of a collection of Electronic Health Records (EHRs). Because a lot of the clinical…

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