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Linear polymers with dendrons of first and second generations based on L-aspargic acid are studied by the methods of flow birefringence and electric birefringence. Optical, dipole, dynamic, and conformational properties of the…

A question of considerable interest to cell membrane biology is whether phase segregated domains across an asymmetric bilayer are strongly correlated with each other and whether phase segregation in one leaflet can induce segregation in the…

Biological Physics · Physics 2015-06-17 Anirban Polley , Satyajit Mayor , Madan Rao

Biological polymers, such as intrinsically disordered proteins, play a central role in cellular biology, including mediating phase separation and controlling activity of biological condensates. The physical properties and functions of…

Dynamic lateral transport of lipids, proteins, and self-assembled structures in biomembranes plays crucial roles in diverse cellular processes. In this study, we perform a coarse-grained molecular dynamics simulation on a vesicle composed…

Soft Condensed Matter · Physics 2023-11-27 Hiroaki Ito , Naofumi Shimokawa , Yuji Higuchi

Cellular membranes are elastic lipid bilayers that contain a variety of proteins, including ion channels, receptors, and scaffolding proteins. These proteins are known to diffuse in the plane of the membrane and to influence the bending of…

Soft Condensed Matter · Physics 2020-10-28 Arijit Mahapatra , David Saintillan , Padmini Rangamani

We investigate two-dimensional crystal assemblies formed by a binary mixture of colloidal particles with a size ratio of 0.88 and driven by short-ranged depletion interactions. Our experiments show that the orientational order of the…

Soft Condensed Matter · Physics 2025-08-18 S. k. Tahmid Shahriar , Chris Feltman , Sean Machler , Nabila Tanjeem

The mechanics of epithelial tissues, which is governed by forces generated in various cell domains, is often investigated using two-dimensional models that account for the apically-positioned actomyosin structures but neglect basolateral…

Soft Condensed Matter · Physics 2024-03-01 Jan Rozman , Matej Krajnc , Primož Ziherl

Ever since the raft model for biomembranes has been proposed, the traditional view of biomembranes based on the fluid-mosaic model has been altered. In the raft model, dynamical heterogeneities in multi-component lipid bilayers play an…

Soft Condensed Matter · Physics 2014-10-16 Shigeyuki Komura , David Andelman

We consider the hydrodynamics of lipid bilayers containing transmembrane proteins of arbitrary shape. This biologically-motivated problem is relevant to the cell membrane, whose fluctuating dynamics play a key role in phenomena ranging from…

Soft Condensed Matter · Physics 2016-10-10 Andrew Callan-Jones , Marc Durand , Jean-Baptiste Fournier

We propose a model that accounts for the budding transition of asymmetric two-component lipid domains, where the two monolayers (leaflets) have different average compositions controlled by independent chemical potentials. Assuming a…

Soft Condensed Matter · Physics 2016-09-16 Jean Wolff , Shigeyuki Komura , David Andelman

The excimer formation dynamics of pyrene-labeled molecules in lipid bilayers depends on molecular motion over distances of the order of 1-2 nm. From the concentration dependence of the excimer photoemission curve, it is possible to derive a…

Soft Condensed Matter · Physics 2022-04-12 Pierre Ayoub , Fabrice Thalmann

The assembly of proteins in membranes plays a key role in many crucial cellular pathways. Despite their importance, characterizing transmembrane assembly remains challenging for experiments and simulations. Equilibrium molecular dynamics…

Soft Condensed Matter · Physics 2024-08-05 Emil Jackel , Gianmarco Lazzeri , Roberto Covino

We study material transport and permeation through a lamellar stack of multi-component lipid membranes by performing Monte Carlo simulations of a stacked two-dimensional Ising model in presence of permeants. In the model, permeants are…

Soft Condensed Matter · Physics 2017-12-29 Takuma Hoshino , Shigeyuki Komura , David Andelman

Monte Carlo simulation performed on a lattice system of biaxial molecules possessing $D_{2h}$ symmetry and interacting with a second rank anisotropic dispersion potential yields three distinct macroscopic phases depending on the biaxiality…

Soft Condensed Matter · Physics 2012-05-31 Nababrata Ghoshal , Kisor Mukhopadhyay , Soumen Kumar Roy

Biological membranes are elastic media in which the presence of a transmembrane protein leads to local bilayer deformation. The energetics of deformation allow two membrane proteins in close proximity to influence each other's equilibrium…

Subcellular Processes · Quantitative Biology 2015-06-26 Tristan Ursell , Kerwyn Huang , Eric Peterson , Rob Phillips

Lipid membranes regulate the flow of materials and information between cells and their organelles. Further, lipid composition and morphology can play a key role in regulating a variety of biological processes. For example, viral uptake,…

Biomolecules · Quantitative Biology 2009-05-12 Tristan Ursell , Rob Phillips

We study the influence of truncating the electrostatic interactions in a fully hydrated pure dipalmitoylphosphatidylcholine (DPPC) bilayer through 20 ns molecular dynamics simulations. The computations in which the electrostatic…

Soft Condensed Matter · Physics 2009-11-07 M. Patra , M. Karttunen , M. Hyvonen , E. Falck , P. Lindqvist , I. Vattulainen

Diffusion in cell membranes is not just simple two-dimensional Brownian motion, but typically depends on the timescale of the observation. The physical origins of this anomalous sub-diffusion are unresolved, and model systems capable of…

Biological Physics · Physics 2017-10-25 H. L. E. Coker , M. R. Cheetham , D. R. Kattnig , Y. J. Wang , S. Garcia-Manyes , M. I. Wallace

We consider a model of bilayer lipid membrane with interdigitation, in which the lipid tails of the opposite monolayers interpenetrate. The interdigitation is modeled by linking tails of the hydrophobic chains in the opposite monolayers…

Quantitative Methods · Quantitative Biology 2009-02-25 Sergei I. Mukhin , Boris B. Kheyfets

In vivo and in vitro lipid bilayers are commonly supported by subcellular structures, particles, and artificial substrates. Deformation of the underlying structure can lead to large, localized deformations as the bilayer deforms to avoid…

Soft Condensed Matter · Physics 2014-03-17 Austin Fergusson , Ravi Kappiyoor , Ganesh Balasubramanian , Ishwar K. Puri , Douglas P. Holmes