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Computational pathology is a domain that aims to develop algorithms to automatically analyze large digitized histopathology images, called whole slide images (WSI). WSIs are produced scanning thin tissue samples that are stained to make…

Image and Video Processing · Electrical Eng. & Systems 2022-01-20 Niccoló Marini , Manfredo Atzori , Sebastian Otálora , Stephane Marchand-Maillet , Henning Müller

Convolutional neural networks (CNNs) are widely used for high-stakes applications like medicine, often surpassing human performance. However, most explanation methods rely on post-hoc attribution, approximating the decision-making process…

Machine Learning · Computer Science 2026-02-23 Kerol Djoumessi , Philipp Berens

Recent advancements in Digital Pathology (DP), particularly through artificial intelligence and Foundation Models, have underscored the importance of large-scale, diverse, and richly annotated datasets. Despite their critical role, publicly…

Image and Video Processing · Electrical Eng. & Systems 2025-05-20 Dmitry Nechaev , Alexey Pchelnikov , Ekaterina Ivanova

Traditional whole slide image (WSI) analysis methods typically rely on the multiple instance learning (MIL) paradigm, which extracts patch-level features at high magnification and aggregates them for slide-level prediction. However, such…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Jiusong Ge , Yingkang Zhan , Wenjie Zhao , Di Zhang , Ke Wang , Jiashuai Liu , Chunze Yang , Chengzu Li , Jian Zhang , Yuxin Dong , Ni Zhang , Qidong Liu , Mireia Crispin-Ortuzar , Huazhu Fu , Chen Li , Zeyu Gao

The histopathological analysis of whole-slide images (WSIs) is fundamental to cancer diagnosis but is a time-consuming and expert-driven process. While deep learning methods show promising results, dominant patch-based methods artificially…

Image and Video Processing · Electrical Eng. & Systems 2025-10-08 Alexander Weers , Alexander H. Berger , Laurin Lux , Peter Schüffler , Daniel Rueckert , Johannes C. Paetzold

Histopathology has played an essential role in cancer diagnosis. With the rapid advances in convolutional neural networks (CNN). Various CNN-based automated pathological image segmentation approaches have been developed in computer-assisted…

Image and Video Processing · Electrical Eng. & Systems 2021-09-23 Cam Nguyen , Zuhayr Asad , Yuankai Huo

Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase commercial…

An important part of breast cancer staging is the assessment of the sentinel axillary node for early signs of tumor spreading. However, this assessment by pathologists is not always easy and retrospective surveys often requalify the status…

Quantitative Methods · Quantitative Biology 2024-04-30 Eric Bonnet

Deep learning methods have emerged as powerful tools for analyzing histopathological images, but current methods are often specialized for specific domains and software environments, and few open-source options exist for deploying models in…

Remarkable progress has been made in image recognition, primarily due to the availability of large-scale annotated datasets and the revival of deep CNN. CNNs enable learning data-driven, highly representative, layered hierarchical image…

Computer Vision and Pattern Recognition · Computer Science 2016-02-11 Hoo-Chang Shin , Holger R. Roth , Mingchen Gao , Le Lu , Ziyue Xu , Isabella Nogues , Jianhua Yao , Daniel Mollura , Ronald M. Summers

Recent advancements in deep learning techniques have spurred considerable interest in their application to hyperspectral imagery processing. This paper provides a comprehensive review of the latest developments in this field, focusing on…

Image and Video Processing · Electrical Eng. & Systems 2024-04-11 Nafiseh Ghasemi , Jon Alvarez Justo , Marco Celesti , Laurent Despoisse , Jens Nieke

Deep convolutional neural networks (CNN) are widely used in modern artificial intelligence (AI) and smart vision systems but also limited by computation latency, throughput, and energy efficiency on a resource-limited scenario, such as…

Hardware Architecture · Computer Science 2017-09-18 Yuan Du , Li Du , Yilei Li , Junjie Su , Mau-Chung Frank Chang

Deep neural networks have demonstrated superior performance in artificial intelligence applications, but the opaqueness of their inner working mechanism is one major drawback in their application. The prevailing unit-based interpretation is…

Computer Vision and Pattern Recognition · Computer Science 2024-02-29 Lei Lyu , Chen Pang , Jihua Wang

Tissue phenotyping is a fundamental computational pathology (CPath) task in learning objective characterizations of histopathologic biomarkers in anatomic pathology. However, whole-slide imaging (WSI) poses a complex computer vision problem…

Deep-learning techniques have been used widely to alleviate the labour-intensive and time-consuming manual annotation required for pixel-level tissue characterization. Our previous study introduced an efficient single dynamic network -…

Image and Video Processing · Electrical Eng. & Systems 2023-05-25 Haoju Leng , Ruining Deng , Zuhayr Asad , R. Michael Womick , Haichun Yang , Lipeng Wan , Yuankai Huo

With pervasive applications of medical imaging in health-care, biomedical image segmentation plays a central role in quantitative analysis, clinical diagno- sis, and medical intervention. Since manual anno- tation su ers limited…

Computer Vision and Pattern Recognition · Computer Science 2018-03-14 Xiaowei Xu , Qing Lu , Yu Hu , Lin Yang , Sharon Hu , Danny Chen , Yiyu Shi

Scene parsing is an important and challenging prob- lem in computer vision. It requires labeling each pixel in an image with the category it belongs to. Tradition- ally, it has been approached with hand-engineered features from color…

Machine Learning · Statistics 2014-11-18 Rahul Mohan

Hyperspectral imaging (HSI) has been extensively utilized for a number of real-world applications. HSI classification (HSIC) is a challenging task due to high inter-class similarity, high intra-class variability, overlapping, and nested…

Image and Video Processing · Electrical Eng. & Systems 2020-12-14 Muhammad Ahmad

We developed a software pipeline for quality control (QC) of histopathology whole slide images (WSIs) that segments various regions, such as blurs of different levels, tissue regions, tissue folds, and pen marks. Given the necessity and…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Abhijeet Patil , Garima Jain , Harsh Diwakar , Jay Sawant , Tripti Bameta , Swapnil Rane , Amit Sethi

The anatomical location of imaging features is of crucial importance for accurate diagnosis in many medical tasks. Convolutional neural networks (CNN) have had huge successes in computer vision, but they lack the natural ability to…

Computer Vision and Pattern Recognition · Computer Science 2016-11-01 Mohsen Ghafoorian , Nico Karssemeijer , Tom Heskes , Inge van Uden , Clara Sanchez , Geert Litjens , Frank-Erik de Leeuw , Bram van Ginneken , Elena Marchiori , Bram Platel