Related papers: Cryo-RALib -- a modular library for accelerating a…

Large language models (LLMs) often struggle with knowledge-intensive tasks due to hallucinations and outdated parametric knowledge. While Retrieval-Augmented Generation (RAG) addresses this by integrating external corpora, its effectiveness…

Despite impressive advancements in recent multimodal reasoning approaches, they are still limited in flexibility and efficiency, as these models typically process only a few fixed modality inputs and require updates to numerous parameters.…

Motivation: Structural heterogeneity in single-particle cryo-electron microscopy (cryo-EM) data represents a major challenge for high-resolution structure determination. Unsupervised classification may serve as the first step in the…

Over the past decade, cryogenic electron microscopy (cryo-EM) has emerged as a primary method for determining near-native, near-atomic resolution 3D structures of biological macromolecules. In order to meet increasing demand for cryo-EM,…

Single-particle electron cryomicroscopy (cryo-EM) is an increasingly popular technique for elucidating the three-dimensional structure of proteins and other biologically significant complexes at near-atomic resolution. It is an imaging…

As inference on Large Language Models (LLMs) emerges as an important workload in machine learning applications, weight quantization has become a standard technique for efficient GPU deployment. Quantization not only reduces model size, but…

As a parameter efficient fine-tuning (PEFT) method, low-rank adaptation (LoRA) can save significant costs in storage and computing, but its strong adaptability to a single task is often accompanied by insufficient cross-task generalization…

The recent improvements in cryo-electron microscopy (cryo-EM) in the past few years are now allowing to observe molecular complexes at atomic resolution. As a consequence, numerous structures derived from cryo-EM are now available in the…

Population-based multi-agent reinforcement learning (PB-MARL) refers to the series of methods nested with reinforcement learning (RL) algorithms, which produces a self-generated sequence of tasks arising from the coupled population…

Large language models (LLMs) are rapidly transforming various domains, including biomedicine and healthcare, and demonstrate remarkable potential from scientific research to new drug discovery. Graph-based retrieval-augmented generation…

Vision Language Action (VLA) models are mainstream in embodied intelligence but face high inference costs. Edge-Cloud Collaborative (ECC) inference offers an effective fix by easing edge-device computing pressure to meet real-time needs.…

With the advent of large language models (LLMs) and multimodal large language models (MLLMs), the potential of retrieval-augmented generation (RAG) has attracted considerable research attention. Various novel algorithms and models have been…

Resolving the structural variability of proteins is often key to understanding the structure-function relationship of those macromolecular machines. Single particle analysis using Cryogenic electron microscopy (CryoEM), combined with…

We introduce SPRING, a novel stochastic proximal alternating linearized minimization algorithm for solving a class of non-smooth and non-convex optimization problems. Large-scale imaging problems are becoming increasingly prevalent due to…

Cryoablation is a minimally invasive localised treatment for prostate cancer that destroys malignant tissue during de-freezing, while sparing surrounding healthy structures. Its success depends on accurate preoperative planning of cryoprobe…

The demand for efficient machine learning (ML) accelerators is growing rapidly, driving the development of novel computing concepts such as resistive random access memory (RRAM)-based tiled computing-in-memory (CIM) architectures. CIM…

In the realm of medical imaging, particularly for COVID-19 detection, deep learning models face substantial challenges such as the necessity for extensive computational resources, the paucity of well-annotated datasets, and a significant…

Bundle adjustment (BA) is a critical technique in various robotic applications such as simultaneous localization and mapping (SLAM), augmented reality (AR), and photogrammetry. BA optimizes parameters such as camera poses and 3D landmarks…

Electron cryo-microscopy (cryo-EM) produces three-dimensional (3D) maps of the electrostatic potential of biological macromolecules, including proteins. Along with knowledge about the imaged molecules, cryo-EM maps allow de novo atomic…

The growing integration of vision-language models (VLMs) in medical applications offers promising support for diagnostic reasoning. However, current medical VLMs often face limitations in generalization, transparency, and computational…