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Purpose - To develop and validate a deep learning (DL) framework for the detection and quantification of drusen and reticular pseudodrusen (RPD) on optical coherence tomography scans. Design - Development and validation of deep learning…

Age-related macular degeneration (AMD) is the leading cause of visual impairment among elderly in the world. Early detection of AMD is of great importance, as the vision loss caused by this disease is irreversible and permanent. Color…

Age-related Macular Degeneration (AMD) is a leading cause of blindness. Although the Age-Related Eye Disease Study group previously developed a 9-step AMD severity scale for manual classification of AMD severity from color fundus images,…

Machine Learning · Computer Science 2018-12-04 Qingyu Chen , Yifan Peng , Tiarnan Keenan , Shazia Dharssi , Elvira Agron , Wai T. Wong , Emily Y. Chew , Zhiyong Lu

In assessing the severity of age-related macular degeneration (AMD), the Age-Related Eye Disease Study (AREDS) Simplified Severity Scale predicts the risk of progression to late AMD. However, its manual use requires the time-consuming…

Computer Vision and Pattern Recognition · Computer Science 2019-01-29 Yifan Peng , Shazia Dharssi , Qingyu Chen , Tiarnan D. Keenan , Elvira Agrón , Wai T. Wong , Emily Y. Chew , Zhiyong Lu

Many diseases are classified based on human-defined rubrics that are prone to bias. Supervised neural networks can automate the grading of retinal fundus images, but require labor-intensive annotations and are restricted to the specific…

Computer Vision and Pattern Recognition · Computer Science 2020-10-26 Baladitya Yellapragada , Sascha Hornhauer , Kiersten Snyder , Stella Yu , Glenn Yiu

Purpose: To validate the performance of a commercially-available, CE-certified deep learning (DL) system, RetCAD v.1.3.0 (Thirona, Nijmegen, The Netherlands), for the joint automatic detection of diabetic retinopathy (DR) and age-related…

This work aims to research an automatic method for detecting Age-related Macular Degeneration (AMD) lesions in RGB eye fundus images. For this, we align invasively obtained eye fundus contrast images (the "golden standard" diagnostic) to…

Image and Video Processing · Electrical Eng. & Systems 2021-10-19 Rokas Pečiulis , Mantas Lukoševičius , Algimantas Kriščiukaitis , Robertas Petrolis , Dovilė Buteikienė

Age related macular degeneration (AMD) is one of the major causes for blindness in the elderly population. In this report, we propose deep learning based methods for retinal analysis using color fundus images for computer aided diagnosis of…

Image and Video Processing · Electrical Eng. & Systems 2020-09-04 Sharath M Shankaranarayana

In light of the expanding population, an automated framework of disease detection can assist doctors in the diagnosis of ocular diseases, yields accurate, stable, rapid outcomes, and improves the success rate of early detection. The work…

Image and Video Processing · Electrical Eng. & Systems 2023-08-31 Md. Aiyub Ali , Md. Shakhawat Hossain , Md. Kawar Hossain , Subhadra Soumi Sikder , Sharun Akter Khushbu , Mirajul Islam

Age-related macular degeneration (AMD) is a degenerative disorder affecting the macula, a key area of the retina for visual acuity. Nowadays, it is the most frequent cause of blindness in developed countries. Although some promising…

Image and Video Processing · Electrical Eng. & Systems 2022-12-06 José Morano , Álvaro S. Hervella , José Rouco , Jorge Novo , José I. Fernández-Vigo , Marcos Ortega

By 2040, age-related macular degeneration (AMD) will affect approximately 288 million people worldwide. Identifying individuals at high risk of progression to late AMD, the sight-threatening stage, is critical for clinical actions,…

Image and Video Processing · Electrical Eng. & Systems 2020-07-21 Yifan Peng , Tiarnan D. Keenan , Qingyu Chen , Elvira Agrón , Alexis Allot , Wai T. Wong , Emily Y. Chew , Zhiyong Lu

Age-related macular degeneration (AMD) is the most common cause of blindness in developed countries, especially in people over 60 years of age. The workload of specialists and the healthcare system in this field has increased in recent…

Image and Video Processing · Electrical Eng. & Systems 2022-02-07 Saman Sotoudeh-Paima , Ata Jodeiri , Fedra Hajizadeh , Hamid Soltanian-Zadeh

We propose a hybrid sequential deep learning model to predict the risk of AMD progression in non-exudative AMD eyes at multiple timepoints, starting from short-term progression (3-months) up to long-term progression (21-months). Proposed…

Quantitative Methods · Quantitative Biology 2019-03-01 Imon Banerjee , Luis de Sisternes , Joelle Hallak , Theodore Leng , Aaron Osborne , Mary Durbin , Daniel Rubin

Age-related macular degeneration (AMD) is a major cause of blindness in older adults, severely affecting vision and quality of life. Despite advances in understanding AMD, the molecular factors driving the severity of subretinal scarring…

Genomics · Quantitative Biology 2024-09-10 Kuan Yan , Yue Zeng , Dai Shi , Ting Zhang , Dmytro Matsypura , Mark C. Gillies , Ling Zhu , Junbin Gao

Background: Patients with neovascular age-related macular degeneration (AMD) can avoid vision loss via certain therapy. However, methods to predict the progression to neovascular age-related macular degeneration (nvAMD) are lacking.…

Computer Vision and Pattern Recognition · Computer Science 2019-04-12 Boris Babenko , Siva Balasubramanian , Katy E. Blumer , Greg S. Corrado , Lily Peng , Dale R. Webster , Naama Hammel , Avinash V. Varadarajan

This paper attacks an emerging challenge of multi-modal retinal disease recognition. Given a multi-modal case consisting of a color fundus photo (CFP) and an array of OCT B-scan images acquired during an eye examination, we aim to build a…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 Xirong Li , Yang Zhou , Jie Wang , Hailan Lin , Jianchun Zhao , Dayong Ding , Weihong Yu , Youxin Chen

Retinal diseases spanning a broad spectrum can be effectively identified and diagnosed using complementary signals from multimodal data. However, multimodal diagnosis in ophthalmic practice is typically challenged in terms of data…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Lu Zhang , Huizhen Yu , Zuowei Wang , Fu Gui , Yatu Guo , Wei Zhang , Mengyu Jia

Purpose: To assess the utility of deep learning in the detection of geographic atrophy (GA) from color fundus photographs; secondary aim to explore potential utility in detecting central GA (CGA). Design: A deep learning model was developed…

Image and Video Processing · Electrical Eng. & Systems 2019-06-10 Tiarnan D. Keenan , Shazia Dharssi , Yifan Peng , Qingyu Chen , Elvira Agrón , Wai T. Wong , Zhiyong Lu , Emily Y. Chew

Age-related macular degeneration (AMD) is one of the leading causes of irreversible vision impairment in people over the age of 60. This research focuses on semantic segmentation for AMD lesion detection in RGB fundus images, a non-invasive…

Computer Vision and Pattern Recognition · Computer Science 2025-10-31 Valentyna Starodub , Mantas Lukoševičius

Raman spectroscopy (RS) has been widely used for disease diagnosis, e.g., cardiovascular disease (CVD), owing to its efficiency and component-specific testing capabilities. A series of popular deep learning methods have recently been…

Image and Video Processing · Electrical Eng. & Systems 2023-04-20 Bo Yu , Hechang Chen , Chengyou Jia , Hongren Zhou , Lele Cong , Xiankai Li , Jianhui Zhuang , Xianling Cong
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