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Motivation: Predicting cellular responses to genetic perturbations is essential for understanding biological systems and developing targeted therapeutic strategies. While variational autoencoders (VAEs) have shown promise in modeling…

Machine Learning · Computer Science 2025-02-03 Seungheun Baek , Soyon Park , Yan Ting Chok , Mogan Gim , Jaewoo Kang

Deep generative models provide flexible frameworks for modeling complex, structured data such as images, videos, 3D objects, and texts. However, when applied to sequences of human skeletons, standard variational autoencoders (VAEs) often…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Arafat Rahman , Shashwat Kumar , Laura E. Barnes , Anuj Srivastava

This study addresses the challenge of statistically extracting generative factors from complex, high-dimensional datasets in unsupervised or semi-supervised settings. We investigate encoder-decoder-based generative models for nonlinear…

Machine Learning · Statistics 2025-07-02 Arkaprabha Ganguli , Nesar Ramachandra , Julie Bessac , Emil Constantinescu

Extracting compact, physically interpretable representations from high-dimensional scientific data is a persistent challenge due to the complex, nonlinear structures inherent in physical systems. We propose a Gaussian Mixture Variational…

Machine Learning · Computer Science 2025-12-01 Tiffany Fan , Murray Cutforth , Marta D'Elia , Alexandre Cortiella , Alireza Doostan , Eric Darve

Most modern probabilistic generative models, such as the variational autoencoder (VAE), have certain indeterminacies that are unresolvable even with an infinite amount of data. Different tasks tolerate different indeterminacies, however…

Machine Learning · Statistics 2023-03-06 Quanhan Xi , Benjamin Bloem-Reddy

Recommendation models are typically trained on observational user interaction data, but the interactions between latent factors in users' decision-making processes lead to complex and entangled data. Disentangling these latent factors to…

Information Retrieval · Computer Science 2023-04-18 Siyu Wang , Xiaocong Chen , Quan Z. Sheng , Yihong Zhang , Lina Yao

This paper addresses the challenges of detecting anomalies in cellular networks in an interpretable way and proposes a new approach using variational autoencoders (VAEs) that learn interpretable representations of the latent space for each…

Machine Learning · Computer Science 2023-06-29 Amandeep Singh , Michael Weber , Markus Lange-Hegermann

Data-driven fault diagnostics of safety-critical systems often faces the challenge of a complete lack of labeled data associated with faulty system conditions (i.e., fault types) at training time. Since an unknown number and nature of fault…

Machine Learning · Computer Science 2020-10-01 Manuel Arias Chao , Bryan T. Adey , Olga Fink

We present a new category of physics-informed neural networks called physics informed variational embedding generative adversarial network (PI-VEGAN), that effectively tackles the forward, inverse, and mixed problems of stochastic…

Machine Learning · Computer Science 2023-07-24 Ruisong Gao , Yufeng Wang , Min Yang , Chuanjun Chen

Paradoxically, a Variational Autoencoder (VAE) could be pushed in two opposite directions, utilizing powerful decoder model for generating realistic images but collapsing the learned representation, or increasing regularization coefficient…

Machine Learning · Computer Science 2022-03-30 Trung Ngo , Najwa Laabid , Ville Hautamäki , Merja Heinäniemi

Natural image modeling is a landmark challenge of unsupervised learning. Variational Autoencoders (VAEs) learn a useful latent representation and model global structure well but have difficulty capturing small details. PixelCNN models…

Machine Learning · Computer Science 2016-11-16 Ishaan Gulrajani , Kundan Kumar , Faruk Ahmed , Adrien Ali Taiga , Francesco Visin , David Vazquez , Aaron Courville

Design of experiments (DOE) is playing an essential role in learning and improving a variety of objects and processes. The article discusses the application of unsupervised machine learning to support the pragmatic designs of complex…

Machine Learning · Computer Science 2021-10-07 Alex Glushkovsky

We present two deep generative models based on Variational Autoencoders to improve the accuracy of drug response prediction. Our models, Perturbation Variational Autoencoder and its semi-supervised extension, Drug Response Variational…

Machine Learning · Statistics 2017-07-07 Ladislav Rampasek , Daniel Hidru , Petr Smirnov , Benjamin Haibe-Kains , Anna Goldenberg

Beta-VAE is a very classical model for disentangled representation learning, the use of an expanding bottleneck that allow information into the decoder gradually is key to representation disentanglement as well as high-quality…

Machine Learning · Computer Science 2023-03-28 Zhouzheng Li , Hao Liu

Disentangled representation learning aims to represent the underlying generative factors of a dataset in a latent representation independently of one another. In our work, we propose a discrete variational autoencoder (VAE) based model…

Computer Vision and Pattern Recognition · Computer Science 2025-11-06 Gulcin Baykal , Melih Kandemir , Gozde Unal

Variational autoencoders (VAEs) have received much attention recently as an end-to-end architecture for text generation with latent variables. In this paper, we investigate several multi-level structures to learn a VAE model to generate…

Computation and Language · Computer Science 2019-06-21 Dinghan Shen , Asli Celikyilmaz , Yizhe Zhang , Liqun Chen , Xin Wang , Jianfeng Gao , Lawrence Carin

The variational auto-encoder (VAE) is a popular method for learning a generative model and embeddings of the data. Many real datasets are hierarchically structured. However, traditional VAEs map data in a Euclidean latent space which cannot…

Machine Learning · Statistics 2019-11-27 Emile Mathieu , Charline Le Lan , Chris J. Maddison , Ryota Tomioka , Yee Whye Teh

In this paper we propose a model that combines the strengths of RNNs and SGVB: the Variational Recurrent Auto-Encoder (VRAE). Such a model can be used for efficient, large scale unsupervised learning on time series data, mapping the time…

Machine Learning · Statistics 2015-06-16 Otto Fabius , Joost R. van Amersfoort

We present a novel method for constructing Variational Autoencoder (VAE). Instead of using pixel-by-pixel loss, we enforce deep feature consistency between the input and the output of a VAE, which ensures the VAE's output to preserve the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-21 Xianxu Hou , Linlin Shen , Ke Sun , Guoping Qiu

While the beta-VAE family is aiming to find disentangled representations and acquire human-interpretable generative factors, like what an ICA (from the linear domain) does, we propose Full Encoder, a novel unified autoencoder framework as a…

Machine Learning · Computer Science 2021-07-14 Zhouzheng Li , Kun Feng
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