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We present a theory of causality in dynamical systems using Koopman operators. Our theory is grounded on a rigorous definition of causal mechanism in dynamical systems given in terms of flow maps. In the Koopman framework, we prove that…

Dynamical Systems · Mathematics 2025-11-06 Adam Rupe , Derek DeSantis , Craig Bakker , Parvathi Kooloth , Jian Lu

We propose a new attribution method for neural networks developed using first principles of causality (to the best of our knowledge, the first such). The neural network architecture is viewed as a Structural Causal Model, and a methodology…

Machine Learning · Computer Science 2019-07-04 Aditya Chattopadhyay , Piyushi Manupriya , Anirban Sarkar , Vineeth N Balasubramanian

With recent advancements in non-invasive techniques for measuring brain activity, such as magnetic resonance imaging (MRI), the study of structural and functional brain networks through graph signal processing (GSP) has gained notable…

Machine Learning · Computer Science 2025-11-13 Martín Schmidt , Sara Silva , Federico Larroca , Gonzalo Mateos , Pablo Musé

Connectomics is a field of neuroscience that analyzes neuronal connections. A connectome is a complete map of a neuronal system, comprising all neuronal connections between its structures. The term "connectome" is close to the word "genome"…

We consider exploratory methods for the discovery of cortical functional connectivity. Typically, data for the i-th subject (i=1...NS) is represented as an NVxNT matrix Xi, corresponding to brain activity sampled at NT moments in time from…

Methodology · Statistics 2011-03-17 Roberto D. Pascual-Marqui , Rolando J. Biscay-Lirio

Imaging neuroscience links brain activation maps to behavior and cognition via correlational studies. Due to the nature of the individual experiments, based on eliciting neural response from a small number of stimuli, this link is…

Machine Learning · Statistics 2013-11-21 Yannick Schwartz , Bertrand Thirion , Gaël Varoquaux

Understanding the intricate architecture of brain networks and its connection to brain function is essential for deciphering the underlying principles of cognition and disease. While traditional graph-theoretical measures have been widely…

Chaotic Dynamics · Physics 2025-11-13 Anca Radulescu , Eva Kaslik , Alexandru Fikl , Johan Nakuci , Sarah Muldoon , Michael Anderson

Identifying the main features and learning the causal relationships of a dynamic system from time-series of sensor data are key problems in many real-world robot applications. In this paper, we propose an extension of a state-of-the-art…

Robotics · Computer Science 2023-02-21 Luca Castri , Sariah Mghames , Marc Hanheide , Nicola Bellotto

Several efforts are currently underway to decipher the connectome or parts thereof in a variety of organisms. Ascertaining the detailed physiological properties of all the neurons in these connectomes, however, is out of the scope of such…

Neurons and Cognition · Quantitative Biology 2014-04-03 Venkatakrishnan Ramaswamy , Arunava Banerjee

One of the crucial questions in neuroscience is how a rich functional repertoire of brain states relates to its underlying structural organization. How to study the associations between these structural and functional layers is an open…

Neurons and Cognition · Quantitative Biology 2018-02-22 Enrico Amico , Joaquín Goñi

Dynamic effective connectivity networks (dECNs) reveal the changing directed brain activity and the dynamic causal influences among brain regions, which facilitate the identification of individual differences and enhance the understanding…

Machine Learning · Computer Science 2025-02-03 Faming Xu , Yiding Wang , Chen Qiao , Gang Qu , Vince D. Calhoun , Julia M. Stephen , Tony W. Wilson , Yu-Ping Wang

Multi-modal neuroimaging technology has greatlly facilitated the efficiency and diagnosis accuracy, which provides complementary information in discovering objective disease biomarkers. Conventional deep learning methods, e.g. convolutional…

Image and Video Processing · Electrical Eng. & Systems 2022-10-26 Yanwu Yang , Xutao Guo , Zhikai Chang , Chenfei Ye , Yang Xiang , Ting Ma

Research in Cognitive Science suggests that humans understand and represent knowledge of the world through causal relationships. In addition to observations, they can rely on experimenting and counterfactual reasoning -- i.e. referring to…

Artificial Intelligence · Computer Science 2021-05-24 Kanvaly Fadiga , Etienne Houzé , Ada Diaconescu , Jean-Louis Dessalles

Studying neural connectivity is considered one of the most promising and challenging areas of modern neuroscience. The underpinnings of cognition are hidden in the way neurons interact with each other. However, our experimental methods of…

Machine Learning · Statistics 2018-06-22 George Panagopoulos

Demystifying effective connectivity among neuronal populations has become the trend to understand the brain mechanisms of Parkinson's disease, schizophrenia, mild traumatic brain injury, and many other unlisted neurological diseases.…

Quantitative Methods · Quantitative Biology 2019-09-27 Po-Ya Hsu

In recent years, new and important perspectives were introduced in the field of neuroimaging with the emergence of the connectionist approach. In this new context, it is important to know not only which brain areas are activated by a…

Neurons and Cognition · Quantitative Biology 2019-04-17 Jean Faber , Priscila C. Antoneli , Guillem Via , Noemi S. Araújo , Daniel J. L. L. Pinheiro , Esper Cavalheiro

In this paper, we develop a generic methodology to encode hierarchical causality structure among observed variables into a neural network in order to improve its predictive performance. The proposed methodology, called causality-informed…

Machine Learning · Computer Science 2024-12-25 Xiaoge Zhang , Xiao-Lin Wang , Fenglei Fan , Yiu-Ming Cheung , Indranil Bose

This paper proposes to study neural networks through neuronal correlation, a statistical measure of correlated neuronal activity on the penultimate layer. We show that neuronal correlation can be efficiently estimated via weight matrix, can…

Machine Learning · Computer Science 2022-01-25 Gaojie Jin , Xinping Yi , Xiaowei Huang

Advances in data analysis and machine learning have revolutionized the study of brain signatures using fMRI, enabling non-invasive exploration of cognition and behavior through individual neural patterns. Functional connectivity (FC), which…

Image and Video Processing · Electrical Eng. & Systems 2025-10-31 Yashaswini , Sanjay Ghosh

Edge time series are increasingly used in brain functional imaging to study the node functional connectivity (nFC) dynamics at the finest temporal resolution while avoiding sliding windows. Here, we lay the mathematical foundations for the…

Neurons and Cognition · Quantitative Biology 2022-07-15 Leonardo Novelli , Adeel Razi
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