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In this paper, we address the problem of identifying protein functionality using the information contained in its aminoacid sequence. We propose a method to define sequence similarity relationships that can be used as input for…

Applications · Statistics 2007-11-12 A. G. Flesia , R. Fraiman , F. G. Leonardi

Semi-supervised learning techniques are gaining popularity due to their capability of building models that are effective, even when scarce amounts of labeled data are available. In this paper, we present a framework and specific tasks for…

Image and Video Processing · Electrical Eng. & Systems 2022-10-05 Antonio Montanaro , Diego Valsesia , Giulia Fracastoro , Enrico Magli

The paradigm of data programming, which uses weak supervision in the form of rules/labelling functions, and semi-supervised learning, which augments small amounts of labelled data with a large unlabelled dataset, have shown great promise in…

Machine Learning · Computer Science 2021-06-15 Ayush Maheshwari , Oishik Chatterjee , KrishnaTeja Killamsetty , Ganesh Ramakrishnan , Rishabh Iyer

Unsupervised clustering on speakers is becoming increasingly important for its potential uses in semi-supervised learning. In reality, we are often presented with enormous amounts of unlabeled data from multi-party meetings and discussions.…

Audio and Speech Processing · Electrical Eng. & Systems 2022-04-26 Fuchuan Tong , Siqi Zheng , Min Zhang , Yafeng Chen , Hongbin Suo , Qingyang Hong , Lin Li

Convolutional neural networks trained using manually generated labels are commonly used for semantic or instance segmentation. In precision agriculture, automated flower detection methods use supervised models and post-processing techniques…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 Abubakar Siddique , Amy Tabb , Henry Medeiros

Deep learning has been widely used for protein engineering. However, it is limited by the lack of sufficient experimental data to train an accurate model for predicting the functional fitness of high-order mutants. Here, we develop SESNet,…

Quantitative Methods · Quantitative Biology 2023-04-10 Mingchen Li , Liqi Kang , Yi Xiong , Yu Guang Wang , Guisheng Fan , Pan Tan , Liang Hong

We report a flexible language-model based deep learning strategy, applied here to solve complex forward and inverse problems in protein modeling, based on an attention neural network that integrates transformer and graph convolutional…

Biomolecules · Quantitative Biology 2023-10-20 Markus J. Buehler

We propose a novel transfer learning approach for orphan screening called corresponding projections. In orphan screening the learning task is to predict the binding affinities of compounds to an orphan protein, i.e., one for which no…

Machine Learning · Computer Science 2018-12-04 Sven Giesselbach , Katrin Ullrich , Michael Kamp , Daniel Paurat , Thomas Gärtner

Hashing methods have been widely used for efficient similarity retrieval on large scale image database. Traditional hashing methods learn hash functions to generate binary codes from hand-crafted features, which achieve limited accuracy…

Computer Vision and Pattern Recognition · Computer Science 2017-11-08 Jian Zhang , Yuxin Peng

Random Fourier features (RFFs) provide a promising way for kernel learning in a spectral case. Current RFFs-based kernel learning methods usually work in a two-stage way. In the first-stage process, learning the optimal feature map is often…

Machine Learning · Computer Science 2024-01-17 Kun Fang , Fanghui Liu , Xiaolin Huang , Jie Yang

In recent years, significant progress has been made in the field of learning from positive and unlabeled examples (PU learning), particularly in the context of advancing image and text classification tasks. However, applying PU learning to…

Image and Video Processing · Electrical Eng. & Systems 2024-05-08 Yan Zhang , Chun Li , Zhaoxia Liu , Ming Li

Deep-learning models such as Convolutional Neural Networks (CNN) and Long Short-Term Memory (LSTM) have been successfully used for process-mining tasks. They have achieved better performance for different predictive tasks than traditional…

Machine Learning · Computer Science 2021-05-04 Ishwar Venugopal , Jessica Töllich , Michael Fairbank , Ansgar Scherp

Traditional genetic programming (GP) often struggles in stock alpha factor discovery due to its vast search space, overwhelming computational burden, and sporadic effective alphas. We find that GP performs better when focusing on promising…

Statistical Finance · Quantitative Finance 2024-12-03 Weizhe Ren , Yichen Qin , Yang Li

We study a semi-supervised learning method based on the similarity graph and RegularizedLaplacian. We give convenient optimization formulation of the Regularized Laplacian method and establishits various properties. In particular, we show…

Machine Learning · Computer Science 2015-08-21 Konstantin Avrachenkov , Pavel Chebotarev , Alexey Mishenin

Protein activity is a significant characteristic for recombinant proteins which can be used as biocatalysts. High activity of proteins reduces the cost of biocatalysts. A model that can predict protein activity from amino acid sequence is…

Quantitative Methods · Quantitative Biology 2018-07-23 X. Han , X. Wang , K. Zhou

The number of studies that combine Evolutionary Machine Learning and self-supervised learning has been growing steadily in recent years. Evolutionary Machine Learning has been shown to help automate the design of machine learning algorithms…

Neural and Evolutionary Computing · Computer Science 2025-11-05 Adriano Vinhas , João Correia , Penousal Machado

Discovering whether words are semantically related and identifying the specific semantic relation that holds between them is of crucial importance for NLP as it is essential for tasks like query expansion in IR. Within this context,…

Computation and Language · Computer Science 2018-07-31 Georgios Balikas , Gaël Dias , Rumen Moraliyski , Massih-Reza Amini

We study the problem of generating keyphrases that summarize the key points for a given document. While sequence-to-sequence (seq2seq) models have achieved remarkable performance on this task (Meng et al., 2017), model training often relies…

Computation and Language · Computer Science 2019-09-09 Hai Ye , Lu Wang

Unsupervised machine learning, and in particular data clustering, is a powerful approach for the analysis of datasets and identification of characteristic features occurring throughout a dataset. It is gaining popularity across scientific…

Mesoscale and Nanoscale Physics · Physics 2021-03-23 Maria El Abbassi , Jan Overbeck , Oliver Braun , Michel Calame , Herre S. J. van der Zant , Mickael L. Perrin

Person re-identification aims to match a person's identity across multiple camera streams. Deep neural networks have been successfully applied to the challenging person re-identification task. One remarkable bottleneck is that the existing…

Computer Vision and Pattern Recognition · Computer Science 2018-05-17 Guodong Ding , Shanshan Zhang , Salman Khan , Zhenmin Tang , Jian Zhang , Fatih Porikli