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Rapidly applying the effects of detector response to physics objects (e.g. electrons, muons, showers of particles) is essential in high energy physics. Currently available tools for the transformation from truth-level physics objects to…

Data Analysis, Statistics and Probability · Physics 2020-07-07 D. Benjamin , S. V. Chekanov , W. Hopkins , Y. Li , J. R. Love

Large language model (LLM) agent evaluators leverage specialized tools to ground the rational decision-making of LLMs, making them well-suited to aid in scientific discoveries, such as constrained retrosynthesis planning. Constrained…

Artificial Intelligence · Computer Science 2025-08-19 Frazier N. Baker , Daniel Adu-Ampratwum , Reza Averly , Botao Yu , Huan Sun , Xia Ning

Synthesis is the automatic construction of a system from its specification. In classical synthesis algorithms it is always assumed that the system is "constructed from scratch" rather than composed from reusable components. This, of course,…

Logic in Computer Science · Computer Science 2011-11-10 Yoad Lustig , Moshe Vardi

Resampling is a key component of sample-based recursive state estimation in particle filters. Recent work explores differentiable particle filters for end-to-end learning. However, resampling remains a challenge in these works, as it is…

Machine Learning · Computer Science 2020-04-28 Michael Zhu , Kevin Murphy , Rico Jonschkowski

Recent progress in machine learning has sparked increased interest in utilizing this technology to predict the outcomes of chemical reactions. The ultimate aim of such endeavors is to develop a universal model that can predict products for…

Chemical Physics · Physics 2025-07-03 Daniel Julian , Jesús Pérez-Ríos

Probabilistic inference procedures are usually coded painstakingly from scratch, for each target model and each inference algorithm. We reduce this effort by generating inference procedures from models automatically. We make this code…

Machine Learning · Statistics 2017-07-13 Robert Zinkov , Chung-chieh Shan

Recent work has proposed a promising approach to improving scalability of program synthesis by allowing the user to supply a syntactic template that constrains the space of potential programs. Unfortunately, creating templates often…

Programming Languages · Computer Science 2017-04-18 Jeevana Priya Inala , Nadia Polikarpova , Xiaokang Qiu , Benjamin S. Lerner , Armando Solar-Lezama

This paper focuses on using natural language descriptions to enhance predictive models in the chemistry field. Conventionally, chemoinformatics models are trained with extensive structured data manually extracted from the literature. In…

Computation and Language · Computer Science 2023-12-11 Yujie Qian , Zhening Li , Zhengkai Tu , Connor W. Coley , Regina Barzilay

Morphogenesis, the establishment and repair of emergent complex anatomy by groups of cells, is a fascinating and biomedically-relevant problem. One of its most fascinating aspects is that a developing embryo can reliably recover from…

Molecular Networks · Quantitative Biology 2022-11-03 Joel Grodstein , Michael Levin

Despite the remarkable success of deep learning systems over the last decade, a key difference still remains between neural network and human decision-making: As humans, we cannot only form a decision on the spot, but also ponder,…

Computer Vision and Pattern Recognition · Computer Science 2023-09-15 Gregor Koehler , Tassilo Wald , Constantin Ulrich , David Zimmerer , Paul F. Jaeger , Jörg K. H. Franke , Simon Kohl , Fabian Isensee , Klaus H. Maier-Hein

Autonomous synthesis and characterization of inorganic materials requires the automatic and accurate analysis of X-ray diffraction spectra. For this task, we designed a probabilistic deep learning algorithm to identify complex multi-phase…

Materials Science · Physics 2021-05-27 Nathan J. Szymanski , Christopher J. Bartel , Yan Zeng , Qingsong Tu , Gerbrand Ceder

Stochastic resetting, the procedure of stopping and re-initializing random processes, has recently emerged as a powerful tool for accelerating processes ranging from queuing systems to molecular simulations. However, its usefulness is…

Statistical Mechanics · Physics 2025-03-18 Tommer D. Keidar , Ofir Blumer , Barak Hirshberg , Shlomi Reuveni

Probabilistic forecasting, i.e. estimating the probability distribution of a time series' future given its past, is a key enabler for optimizing business processes. In retail businesses, for example, forecasting demand is crucial for having…

Artificial Intelligence · Computer Science 2019-02-25 David Salinas , Valentin Flunkert , Jan Gasthaus

Mode decomposition is a prototypical pattern recognition problem that can be addressed from the (a priori distinct) perspectives of numerical approximation, statistical inference and deep learning. Could its analysis through these combined…

Machine Learning · Statistics 2020-08-07 Houman Owhadi , Clint Scovel , Gene Ryan Yoo

The Human Genome Project has led to an exponential increase in data related to the sequence, structure, and function of biomolecules. Bioinformatics is an interdisciplinary research field that primarily uses computational methods to analyze…

Biomolecules · Quantitative Biology 2024-05-14 Yanlin Zhou , Tong Zhan , Yichao Wu , Bo Song , Chenxi Shi

Determining protein structures at an atomic level remains a significant challenge in structural biology. We introduce $\texttt{RecCrysFormer}$, a hybrid model that exploits the strengths of transformers with the aim of integrating…

Quantitative Methods · Quantitative Biology 2026-01-30 Tom Pan , Evan Dramko , Mitchell D. Miller , George N. Phillips , Anastasios Kyrillidis

A significant challenge in wet lab experiments with current drug design generative models is the trade-off between pharmacological properties and synthesizability. Molecules predicted to have highly desirable properties are often difficult…

Machine Learning · Computer Science 2025-04-04 Songtao Liu , Dandan Zhang , Zhengkai Tu , Hanjun Dai , Peng Liu

Controller synthesis is the process of constructing a correct system automatically from its specification. This often requires assumptions about the behaviour of the environment. It is difficult for the designer to identify the assumptions…

Logic in Computer Science · Computer Science 2016-04-13 Romain Brenguier

With the advent of high-throughput profiling methods, interest in reverse engineering the structure and dynamics of biochemical networks is high. Recently an algorithm for reverse engineering of biochemical networks was developed by…

Quantitative Methods · Quantitative Biology 2010-01-18 Edgar Delgado-Eckert

Switching between different levels of resolution is essential for multiscale modeling, but restoring details at higher resolution remains challenging. In our previous study we have introduced deepBackmap: a deep neural-network-based…

Chemical Physics · Physics 2024-06-12 Marc Stieffenhofer , Tristan Bereau , Michael Wand