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Many chemical reactions can be formulated in terms of particle diffusion in a complex energy landscape. Transition path theory (TPT) is a theoretical framework for describing the direct (reaction) pathways from reactant to product states…

Statistical Mechanics · Physics 2023-10-03 Paul C Bressloff

We extend the random walk framework to include compounded steps, providing first-passage time (FPT) properties for a new class of superdiffusive processes, which are governed by the space-fractional spectral Fokker-Planck equation. This…

Statistical Mechanics · Physics 2026-04-14 Christopher N. Angstmann , Daniel S. Han , Bruce I. Henry , Boris Z. Huang

The statistics of first-passage times of random walks to target sites has proved to play a key role in determining the kinetics of space exploration in various contexts. In parallel, the number of distinct sites visited by a random walker…

Statistical Mechanics · Physics 2022-03-23 J. Klinger , A. Barbier-Chebbah , R. Voituriez , O. Bénichou

By periodically returning a search process to a known or random state, random resetting possesses the potential to unveil new trajectories, sidestep potential obstacles, and consequently enhance the efficiency of locating desired targets.…

Statistical Mechanics · Physics 2024-12-31 Arnab Pal , Viktor Stojkoski , Trifce Sandev

An ensemble of trajectories with dynamical activity and first-passage time (FPT) is considered in the context of the thermodynamics of trajectories. The relationship between the average FPT and the total change in entropy is determined,…

Statistical Mechanics · Physics 2024-12-10 V. V. Ryazanov

How to best exploit patchy resources? This long-standing question belongs to the extensively studied class of explore/exploit problems that arise in a wide range of situations, from animal foraging, to robotic exploration, and to human…

Populations and Evolution · Quantitative Biology 2017-01-31 M. Chupeau , O. Benichou , S. Redner

Often sharp changes in cellular behavior are triggered by thresholded events, i.e., by the attainment of a threshold value of a relevant cellular or molecular dynamical variable. Since the governing variable itself typically undergoes noisy…

Statistical Mechanics · Physics 2015-03-03 Srividya Iyer-Biswas , Anton Zilman

Efficient search acts as a strong selective force in biological systems ranging from cellular populations to predator-prey systems. The search processes commonly involve finding a stationary or mobile target within a heterogeneously…

Biological Physics · Physics 2018-01-03 Youness Azimzade , Alireza Mashaghi

Agents searching for a target can improve their efficiency by memorizing where they have already been searching or by cooperating with other searchers and using strategies that benefit from collective effects. This chapter reviews such…

Statistical Mechanics · Physics 2023-11-10 Hugues Meyer , Heiko Rieger

Feature allocation models postulate a sampling distribution whose parameters are derived from shared features. Bayesian models place a prior distribution on the feature allocation, and Markov chain Monte Carlo is typically used for model…

Methodology · Statistics 2022-07-29 David B. Dahl , Devin J. Johnson , R. Jacob Andros

In general, the power-law degree distribution has profound influence on various dynamical processes defined on scale-free networks. In this paper, we will show that power-law degree distribution alone does not suffice to characterize the…

Statistical Mechanics · Physics 2009-12-09 Zhongzhi Zhang , Weilen Xie , Shuigeng Zhou , Mo Li , Jihong Guan

A random search of a partially absorbing target by a run-and-tumble particle in a confined one-dimensional space is investigated. We analytically obtain the mean searching time, which shows a non-monotonic behavior as a function of the…

Statistical Mechanics · Physics 2023-10-09 Euijin Jeon , Byeongguk Go , Yong Woon Kim

The first passage time (FPT) distribution for random walk in complex networks is calculated through an asymptotic analysis. For network with size $N$ and short relaxation time $\tau\ll N$, the computed mean first passage time (MFPT), which…

Statistical Mechanics · Physics 2013-01-29 Hon Wai Lau , Kwok Yip Szeto

Brownian diffusion subject to stochastic resetting to a fixed position has been widely studied for applications to random search processes. In an unbounded domain, the mean first-passage time at a target site can be minimized for a…

Statistical Mechanics · Physics 2025-10-08 Pedro Julián-Salgado , Leonardo Dagdug , Denis Boyer

Random walks constitute a fundamental mechanism for a large set of dynamics taking place on networks. In this article, we study random walks on weighted networks with an arbitrary degree distribution, where the weight of an edge between two…

Statistical Mechanics · Physics 2013-01-17 Zhongzhi Zhang , Tong Shan , Guanrong Chen

Many biological processes involve one dimensional diffusion over a correlated inhomogeneous energy landscape with a correlation length $\xi_c$. Typical examples are specific protein target location on DNA, nucleosome repositioning, or DNA…

Biomolecules · Quantitative Biology 2007-05-23 Michael Slutsky , Mehran Kardar , Leonid A. Mirny

In this paper we study some aspects of search for an immobile target by a swarm of N non-communicating, randomly moving searchers (numbered by the index k, k = 1, 2,..., N), which all start their random motion simultaneously at the same…

Statistical Mechanics · Physics 2011-07-01 C. Mejia-Monasterio , G. Oshanin , G. Schehr

This study investigates the first passage time (FPT) properties of particles with a broad class of positive stochastic diffusion coefficients (DCs), representing diffusion in heterogeneous environments or of particles with conformational…

Statistical Mechanics · Physics 2026-05-18 Go Uchida , Hiromi Miyoshi , Hitoshi Washizu

The first time a searcher finds a target is called a first passage time (FPT). In many physical, chemical, and biological processes, the searcher is "mortal," which means that the searcher might become inactivated (degrade, die, etc.)…

Probability · Mathematics 2021-02-25 Sean D Lawley

The first-passage time (FPT) is the time it takes a system variable to cross a given boundary for the first time. In the context of Markov networks, the FPT is the time a random walker takes to reach a particular node (target) by hopping…

Molecular Networks · Quantitative Biology 2024-03-22 Jaroslav Albert