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Quantum computational chemistry holds great promise for simulating molecular systems more efficiently than classical methods by leveraging quantum bits to represent molecular wavefunctions. However, current implementations face significant…

Quantum Physics · Physics 2025-09-10 Weitang Li , Shi-Xin Zhang , Zirui Sheng , Cunxi Gong , Jianpeng Chen , Zhigang Shuai

Molecular optimization in drug discovery aims to discover molecules with improved target properties, but practical lead optimization often requires more than high predicted scores. A useful candidate should also be actionable: it should be…

Machine Learning · Computer Science 2026-05-12 Yang Qiao , Bo Pan , Hao-Wei Pang , Peter Zhiping Zhang , Liying Zhang , Liang Zhao

Feature selection is critical in machine learning to reduce dimensionality and improve model accuracy and efficiency. The exponential growth in feature space dimensionality for modern datasets directly results in ambiguous samples and…

Quantum Physics · Physics 2023-11-30 Haiyan Wang

Quantum-inspired classical algorithms has received much attention due to its exponential speedup compared to existing algorithms, under certain data storage assumptions. The improvements are noticeable in fundamental linear algebra tasks.…

Quantum Physics · Physics 2025-12-08 Hyunho Cha , Jungwoo Lee

Engineering design processes involve iterative design evaluations requiring numerous computationally intensive numerical simulations. Quantum algorithms promise substantial speedups for specific tasks relevant to engineering simulations.…

Quantum Physics · Physics 2026-03-26 Leonhard Hölscher , Lukas Müller , Or Samimi , Tamuz Danzig

Quantum machine learning (QML) has great potential for the analysis of chemical datasets. However, conventional quantum data-encoding schemes, such as fingerprint encoding, are generally unfeasible for the accurate representation of…

Quantum Physics · Physics 2025-11-18 Choy Boy , Edoardo Altamura , Dilhan Manawadu , Ivano Tavernelli , Stefano Mensa , David J. Wales

Molecular docking plays a pivotal role in drug discovery and precision medicine, enabling us to understand protein functions and advance novel therapeutics. Here, we introduce a potential alternative solution to this problem, the…

Quantum Physics · Physics 2024-05-17 Qi-Ming Ding , Yi-Ming Huang , Xiao Yuan

The predictive accuracy of Machine Learning (ML) models of molecular properties depends on the choice of the molecular representation. Based on the postulates of quantum mechanics, we introduce a hierarchy of representations which meet…

Chemical Physics · Physics 2016-11-23 Bing Huang , O. Anatole von Lilienfeld

Supervised Quantum Machine Learning (QML) represents an intersection of quantum computing and classical machine learning, aiming to use quantum resources to support model training and inference. This paper reviews recent developments in…

Quantum Physics · Physics 2025-06-26 Srikanth Thudumu , Jason Fisher , Hung Du

Quantum Machine Learning (QML) continues to evolve, unlocking new opportunities for diverse applications. In this study, we investigate and evaluate the applicability of QML models for binary classification of genome sequence data by…

Machine Learning · Computer Science 2025-01-15 Navneet Singh , Shiva Raj Pokhrel

This work describes the selection approach and analysis of existing AutoML frameworks regarding their capability of a) incorporating Quantum Machine Learning (QML) algorithms into this automated solving approach of the AutoML framing and b)…

Machine Learning · Computer Science 2023-10-09 Dennis Klau , Marc Zöller , Christian Tutschku

This paper introduces a novel quantum embedding search algorithm (QES, pronounced as "quest"), enabling search for optimal quantum embedding design for a specific dataset of interest. First, we establish the connection between the…

Quantum Physics · Physics 2022-04-20 Nam Nguyen , Kwang-Chen Chen

Quantum metrology plays a fundamental role in many scientific areas. However, the complexity of engineering entangled probes and the external noise raise technological barriers for realizing the expected precision of the to-be-estimated…

Quantum Physics · Physics 2021-01-21 Xiaodong Yang , Xi Chen , Jun Li , Xinhua Peng , Raymond Laflamme

Quantum optimization algorithms (QOAs) have the potential to fundamentally transform the application of optimization methods in decision making. For certain classes of optimization problems, it is widely believed that QOA enables…

Quantum Physics · Physics 2024-01-15 Florian Klug

Recent advances in language models have enabled framing molecule generation as sequence modeling. However, existing approaches often rely on single-objective reinforcement learning, limiting their applicability to real-world drug design,…

Machine Learning · Computer Science 2025-02-11 Diego Calanzone , Pierluca D'Oro , Pierre-Luc Bacon

Recent studies on quantum computing algorithms focus on excavating features of quantum computers which have potential for contributing to computational model enhancements. Among various approaches, quantum annealing methods effectively…

Quantum Physics · Physics 2021-11-02 Sun Woo Park , Hyunju Lee , Byung Chun Kim , Youngho Woo , Kyungtaek Jun

The rapid advancement of quantum computing (QC) and machine learning (ML) has given rise to the burgeoning field of quantum machine learning (QML), aiming to capitalize on the strengths of quantum computing to propel ML forward. Despite its…

Quantum Physics · Physics 2024-07-30 Xin Dai , Tzu-Chieh Wei , Shinjae Yoo , Samuel Yen-Chi Chen

The Quantum Approximate Optimization Algorithm (QAOA) has emerged as a promising variational quantum algorithm for addressing NP hard combinatorial optimization problems. However, a significant limitation lies in optimizing its classical…

Quantum Physics · Physics 2023-09-22 Peter Gleißner , Georg Kruse , Andreas Roßkopf

Finding optimal solutions of conflicting objectives is a daily matter in many industrial applications, with multi-objective optimization trying to find the best solutions to them. The advent of quantum computing has led to researchers…

Quantum computing has attracted significant interest in the optimization community because it potentially can solve classes of optimization problems faster than conventional supercomputers. Several researchers proposed quantum computing…

Quantum Physics · Physics 2023-02-14 Mohammadhossein Mohammadisiahroudi , Ramin Fakhimi , Tamás Terlaky