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High-dimensional design spaces underpin a wide range of physics-based modeling and computational design tasks in science and engineering. These problems are commonly formulated as constrained black-box searches over rugged objective…

Machine Learning · Computer Science 2026-01-13 Suvo Banik , Troy D. Loeffler , Henry Chan , Sukriti Manna , Orcun Yildiz , Tom Peterka , Subramanian Sankaranarayanan

The quality of mesh generation has long been considered a vital aspect in providing engineers with reliable simulation results throughout the history of the Finite Element Method (FEM). The element extraction method, which is currently the…

Machine Learning · Computer Science 2023-05-02 Hua Tong

Due to the large combinatorial problem, current beam orientation optimization algorithms for radiotherapy, such as column generation (CG), are typically heuristic or greedy in nature, leading to suboptimal solutions. We propose a…

Medical Physics · Physics 2020-04-15 Azar Sadeghnejad-Barkousaraie , Gyanendra Bohara , Steve Jiang , Dan Nguyen

Monte Carlo Tree Search (MCTS) is an effective test-time compute scaling (TTCS) method for improving the reasoning performance of large language models, but its highly variable execution time leads to severe long-tail latency in practice.…

Artificial Intelligence · Computer Science 2026-04-02 Hongbeen Kim , Juhyun Lee , Sanghyeon Lee , Kwanghoon Choi , Jaehyuk Huh

Designing molecular structures with desired chemical properties is an essential task in drug discovery and material design. However, finding molecules with the optimized desired properties is still a challenging task due to combinatorial…

Biomolecules · Quantitative Biology 2023-02-02 Masatsugu Yamada , Mahito Sugiyama

Molecular generation, an essential method for identifying new drug structures, has been supported by advancements in machine learning and computational technology. However, challenges remain in multi-objective generation, model…

Biomolecules · Quantitative Biology 2024-04-11 Ningfeng Liu , Jie Yu , Siyu Xiu , Xinfang Zhao , Siyu Lin , Bo Qiang , Ruqiu Zheng , Hongwei Jin , Liangren Zhang , Zhenming Liu

Molecular conformation generation aims to generate three-dimensional coordinates of all the atoms in a molecule and is an important task in bioinformatics and pharmacology. Previous methods usually first predict the interatomic distances,…

Artificial Intelligence · Computer Science 2023-01-02 Jinhua Zhu , Yingce Xia , Chang Liu , Lijun Wu , Shufang Xie , Yusong Wang , Tong Wang , Tao Qin , Wengang Zhou , Houqiang Li , Haiguang Liu , Tie-Yan Liu

Monte-Carlo tree search (MCTS) is an effective anytime algorithm with a vast amount of applications. It strategically allocates computational resources to focus on promising segments of the search tree, making it a very attractive search…

Artificial Intelligence · Computer Science 2024-02-14 Cedric Derstroff , Jannis Brugger , Jannis Blüml , Mira Mezini , Stefan Kramer , Kristian Kersting

Competitive program generation aims to automatically produce correct and efficient solutions for programming-contest problems under strict time and memory constraints. Existing LLM-based approaches often fail to perform explicit algorithmic…

Software Engineering · Computer Science 2026-05-05 Minnan Wei , Xiang Chen , Xiaoshuai Niu , Siyu Chen

Monte Carlo Tree Search (MCTS) is an immensely popular search-based framework used for decision making. It is traditionally applied to domains where a perfect simulation model of the environment is available. We study and improve MCTS in…

Artificial Intelligence · Computer Science 2024-05-24 Farnaz Kohankhaki , Kiarash Aghakasiri , Hongming Zhang , Ting-Han Wei , Chao Gao , Martin Müller

We explore applying the Monte Carlo Tree Search (MCTS) algorithm in a notoriously difficult task: tuning programs for high-performance deep learning and image processing. We build our framework on top of Halide and show that MCTS can…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-05-29 Ameer Haj-Ali , Hasan Genc , Qijing Huang , William Moses , John Wawrzynek , Krste Asanović , Ion Stoica

In this work, we aim to develop an MLLM that understands and solves questions by learning to create each intermediate step of the reasoning involved till the final answer. To this end, we propose Collective Monte Carlo Tree Search (CoMCTS),…

Computer Vision and Pattern Recognition · Computer Science 2025-01-03 Huanjin Yao , Jiaxing Huang , Wenhao Wu , Jingyi Zhang , Yibo Wang , Shunyu Liu , Yingjie Wang , Yuxin Song , Haocheng Feng , Li Shen , Dacheng Tao

Making changes to a program to optimize its performance is an unscalable task that relies entirely upon human intuition and experience. In addition, companies operating at large scale are at a stage where no single individual understands…

Machine Learning · Computer Science 2020-05-08 Don M. Dini

The maximum reachability probabilities in a Markov decision process can be computed using value iteration (VI). Recently, simulation-based heuristic extensions of VI have been introduced, such as bounded real-time dynamic programming…

Logic in Computer Science · Computer Science 2018-09-11 Pranav Ashok , Tomáš Brázdil , Jan Křetínský , Ondřej Slámečka

Automatic food recipe generation methods provide a creative tool for chefs to explore and to create new, and interesting culinary delights. Given the recent success of large language models (LLMs), they have the potential to create new…

Computation and Language · Computer Science 2024-01-11 Karan Taneja , Richard Segal , Richard Goodwin

In this study, we explore the efficiency of the Monte Carlo Tree Search (MCTS), a prominent decision-making algorithm renowned for its effectiveness in complex decision environments, contingent upon the volume of simulations conducted.…

Artificial Intelligence · Computer Science 2024-03-19 Ye Zhang , Mengran Zhu , Kailin Gui , Jiayue Yu , Yong Hao , Haozhan Sun

Monte-Carlo Tree Search (MCTS) methods, such as Upper Confidence Bound applied to Trees (UCT), are instrumental to automated planning techniques. However, UCT can be slow to explore an optimal action when it initially appears inferior to…

Artificial Intelligence · Computer Science 2024-04-12 Michael Painter , Mohamed Baioumy , Nick Hawes , Bruno Lacerda

Monte Carlo Tree Search (MCTS) algorithms have achieved great success on many challenging benchmarks (e.g., Computer Go). However, they generally require a large number of rollouts, making their applications costly. Furthermore, it is also…

Machine Learning · Computer Science 2020-02-27 Anji Liu , Jianshu Chen , Mingze Yu , Yu Zhai , Xuewen Zhou , Ji Liu

Physics-based simulations and learning-based models are vital for complex robotics tasks like deformable object manipulation and liquid handling. However, these models often struggle with accuracy due to epistemic uncertainty or the…

Robotics · Computer Science 2025-07-29 Marco Faroni , Carlo Odesco , Andrea Zanchettin , Paolo Rocco

Generative models are becoming a tool of choice for exploring the molecular space. These models learn on a large training dataset and produce novel molecular structures with similar properties. Generated structures can be utilized for…