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Large Language Models (LLMs) have become a cornerstone in Natural Language Processing (NLP), achieving impressive performance in text generation. Their token-level representations capture rich, human-aligned semantics. However, pooling…

Computation and Language · Computer Science 2025-09-25 Benedikt Roth , Stephan Rappensperger , Tianming Qiu , Hamza Imamović , Julian Wörmann , Hao Shen

Deep embeddings answer one simple question: How similar are two images? Learning these embeddings is the bedrock of verification, zero-shot learning, and visual search. The most prominent approaches optimize a deep convolutional network…

Computer Vision and Pattern Recognition · Computer Science 2018-01-17 Chao-Yuan Wu , R. Manmatha , Alexander J. Smola , Philipp Krähenbühl

Dense document embeddings are central to neural retrieval. The dominant paradigm is to train and construct embeddings by running encoders directly on individual documents. In this work, we argue that these embeddings, while effective, are…

Computation and Language · Computer Science 2024-11-11 John X. Morris , Alexander M. Rush

Accurate prediction of enzymatic activity from amino acid sequences could drastically accelerate enzyme engineering for applications such as bioremediation and therapeutics development. In recent years, Protein Language Model (PLM)…

Quantitative Methods · Quantitative Biology 2025-05-07 Duncan F. Muir , Parker Grosjean , Margaux M. Pinney , Michael J. Keiser

Representation learning is a fundamental building block for analyzing entities in a database. While the existing embedding learning methods are effective in various data mining problems, their applicability is often limited because these…

Machine Learning · Computer Science 2020-09-24 Chin-Chia Michael Yeh , Dhruv Gelda , Zhongfang Zhuang , Yan Zheng , Liang Gou , Wei Zhang

The rise of deep learning has marked significant progress in fields such as computer vision, natural language processing, and medical imaging, primarily through the adaptation of pre-trained models for specific tasks. Traditional…

Machine Learning · Computer Science 2024-04-25 Charith Chandra Sai Balne , Sreyoshi Bhaduri , Tamoghna Roy , Vinija Jain , Aman Chadha

Investigating linguistic relationships on a global scale requires analyzing diverse features such as syntax, phonology and prosody, which evolve at varying rates influenced by internal diversification, language contact, and sociolinguistic…

Computation and Language · Computer Science 2025-06-11 Tuukka Törö , Antti Suni , Juraj Šimko

Embedded spaces are a key feature in deep learning. Good embedded spaces represent the data well to support classification and advanced techniques such as open-set recognition, few-short learning and explainability. This paper presents a…

Machine Learning · Computer Science 2024-08-06 Stefan Scholl

Large language model (LLM)-based embedding models, benefiting from large scale pre-training and post-training, have begun to surpass BERT and T5-based models on general-purpose text embedding tasks such as document retrieval. However, a…

Computation and Language · Computer Science 2025-05-22 Siyue Zhang , Yilun Zhao , Liyuan Geng , Arman Cohan , Anh Tuan Luu , Chen Zhao

Predicting ATP-Protein Binding sites in genes is of great significance in the field of Biology and Medicine. The majority of research in this field has been conducted through time- and resource-intensive 'wet experiments' in laboratories.…

Biomolecules · Quantitative Biology 2024-02-06 Shreyas V , Swati Agarwal

Embedding models have become essential tools in both natural language processing and computer vision, enabling efficient semantic search, recommendation, clustering, and more. However, the high memory and computational demands of…

Computation and Language · Computer Science 2024-11-26 Jiayi Chen , Chen Wu , Shaoqun Zhang , Nan Li , Liangjie Zhang , Qi Zhang

We apply the concept of subset seeds proposed in [1] to similarity search in protein sequences. The main question studied is the design of efficient seed alphabets to construct seeds with optimal sensitivity/selectivity trade-offs. We…

Quantitative Methods · Quantitative Biology 2011-01-18 Mikhail A. Roytberg , Anna Gambin , Laurent Noé , Slawomir Lasota , Eugenia Furletova , Ewa Szczurek , Gregory Kucherov

Mining large-scale high-throughput tandem mass spectrometry data sets is a very important problem in mass spectrometry based protein identification. One of the fundamental problems in large scale mining of spectra is to design appropriate…

Quantitative Methods · Quantitative Biology 2007-05-23 Debojyoti Dutta , Ting Chen

Dense retrieval calls for discriminative embeddings to represent the semantic relationship between query and document. It may benefit from the using of large language models (LLMs), given LLMs' strong capability on semantic understanding.…

Computation and Language · Computer Science 2025-11-25 Zheng Liu , Chaofan Li , Shitao Xiao , Yingxia Shao , Defu Lian

Large language models (LLMs) acquire knowledge across diverse domains such as science, history, and geography encountered during generative pre-training. However, due to their stochasticity, it is difficult to predict what LLMs have…

Computation and Language · Computer Science 2026-01-27 Kartik Sharma , Yiqiao Jin , Rakshit Trivedi , Srijan Kumar

The Vision Language Model (VLM) excels in aligning vision and language representations, and prompt learning has emerged as a key technique for adapting such models to downstream tasks. However, the application of prompt learning with VLM in…

Machine Learning · Computer Science 2025-09-19 Zhihao Wang , Wenke Huang , Tian Chen , Zekun Shi , Guancheng Wan , Yu Qiao , Bin Yang , Jian Wang , Bing Li , Mang Ye

Machine- and deep-learning approaches for biological sequences depend critically on transforming raw DNA, RNA, and protein FASTA files into informative numerical representations. However, this process is often fragmented across multiple…

Genomics · Quantitative Biology 2025-12-01 Hamid Ismail , Marwan Bikdash

Recommendation algorithms that incorporate techniques from deep learning are becoming increasingly popular. Due to the structure of the data coming from recommendation domains (i.e., one-hot-encoded vectors of item preferences), these…

Machine Learning · Computer Science 2017-06-14 Joan Serrà , Alexandros Karatzoglou

Due to the usefulness in data enrichment for data analysis tasks, joinable table discovery has become an important operation in data lake management. Existing approaches target equi-joins, the most common way of combining tables for…

Databases · Computer Science 2023-06-26 Yuyang Dong , Chuan Xiao , Takuma Nozawa , Masafumi Enomoto , Masafumi Oyamada

Effectively training language models on long inputs poses many technical challenges. As a cost consideration, languages models are pretrained on a fixed sequence length before being adapted to longer sequences. We explore various methods…

Computation and Language · Computer Science 2024-06-21 Petros Karypis , Julian McAuley , George Karypis