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The backpropagation algorithm is an invaluable tool for training artificial neural networks; however, because of a weight sharing requirement, it does not provide a plausible model of brain function. Here, in the context of a two-layer…

Neural and Evolutionary Computing · Computer Science 2020-12-01 Siavash Golkar , David Lipshutz , Yanis Bahroun , Anirvan M. Sengupta , Dmitri B. Chklovskii

Despite evidence for the existence of engrams as memory support structures in our brains, there is no consensus framework in neuroscience as to what their physical implementation might be. Here we propose how we might design a computer…

Neurons and Cognition · Quantitative Biology 2023-03-03 Jesus Marco de Lucas

The backpropagation algorithm, or backprop, is a widely utilized optimization technique in deep learning. While there's growing evidence suggesting that models trained with backprop can accurately explain neuronal data, no backprop-like…

Machine Learning · Computer Science 2024-05-28 Gananath R

The artificial neural network is a popular framework in machine learning. To empower individual neurons, we recently suggested that the current type of neurons could be upgraded to 2nd order counterparts, in which the linear operation…

Machine Learning · Computer Science 2017-08-22 Fenglei Fan , Wenxiang Cong , Ge Wang

By and large, Backpropagation (BP) is regarded as one of the most important neural computation algorithms at the basis of the progress in machine learning, including the recent advances in deep learning. However, its computational structure…

Artificial Intelligence · Computer Science 2018-08-22 Alessandro Betti , Marco Gori , Giuseppe Marra

The de facto algorithm for training the back pass of a feedforward neural network is backpropagation (BP). The use of almost-everywhere differentiable activation functions made it efficient and effective to propagate the gradient backwards…

Neural and Evolutionary Computing · Computer Science 2022-06-14 John Waldo

Brains remain unrivaled in their ability to recognize and generate complex spatiotemporal patterns. While AI is able to reproduce some of these capabilities, deep learning algorithms remain largely at odds with our current understanding of…

Neurons and Cognition · Quantitative Biology 2026-03-13 Simon Brandt , Paul Haider , Walter Senn , Federico Benitez , Mihai A. Petrovici

Backpropagation (BP), the standard learning algorithm for artificial neural networks, is often considered biologically implausible. In contrast, the standard learning algorithm for predictive coding (PC) models in neuroscience, known as the…

Neural and Evolutionary Computing · Computer Science 2023-05-24 Nick Alonso , Jeff Krichmar , Emre Neftci

The field of artificial intelligence faces significant challenges in achieving both biological plausibility and computational efficiency, particularly in visual learning tasks. Current artificial neural networks, such as convolutional…

Machine Learning · Computer Science 2024-09-27 Jacobo Ruiz , Manas Gupta

Deep learning has redefined the field of artificial intelligence (AI) thanks to the rise of artificial neural networks, which are architectures inspired by their neurological counterpart in the brain. Through the years, this dualism between…

Machine Learning · Computer Science 2023-02-21 Tommaso Salvatori , Yuhang Song , Thomas Lukasiewicz , Rafal Bogacz , Zhenghua Xu

We describe recurrent neural networks (RNNs), which have attracted great attention on sequential tasks, such as handwriting recognition, speech recognition and image to text. However, compared to general feedforward neural networks, RNNs…

Machine Learning · Computer Science 2018-01-16 Gang Chen

In our previous work, we proposed that engrams in the brain could be biologically implemented as autoencoders over recurrent neural networks. These autoencoders would comprise basic excitatory/inhibitory motifs, with credit assignment…

Neural and Evolutionary Computing · Computer Science 2024-07-24 J Marco de Lucas

Backpropagation (BP) is the standard algorithm for training the deep neural networks that power modern artificial intelligence including large language models. However, BP is energy inefficient and unlikely to be implemented by the brain.…

Machine Learning · Computer Science 2025-10-30 Francesco Innocenti

Training a neural network using backpropagation algorithm requires passing error gradients sequentially through the network. The backward locking prevents us from updating network layers in parallel and fully leveraging the computing…

Machine Learning · Computer Science 2019-05-30 Zhouyuan Huo , Bin Gu , Heng Huang

The brain processes information through many layers of neurons. This deep architecture is representationally powerful, but it complicates learning by making it hard to identify the responsible neurons when a mistake is made. In machine…

Neurons and Cognition · Quantitative Biology 2014-11-04 Timothy P. Lillicrap , Daniel Cownden , Douglas B. Tweed , Colin J. Akerman

Back-propagation algorithm is one of the most widely used and popular techniques to optimize the feed forward neural network training. Nature inspired meta-heuristic algorithms also provide derivative-free solution to optimize complex…

Neural and Evolutionary Computing · Computer Science 2012-09-13 Sudarshan Nandy , Partha Pratim Sarkar , Achintya Das

Backpropagation of error (backprop) is a powerful algorithm for training machine learning architectures through end-to-end differentiation. However, backprop is often criticised for lacking biological plausibility. Recently, it has been…

Machine Learning · Computer Science 2020-10-07 Beren Millidge , Alexander Tschantz , Christopher L. Buckley

Backpropagation is the core learning mechanism underlying deep learning. However, whether and how this algorithm is implemented in the brain remains highly debated. In particular, while forward activations of pretrained models reliably map…

Despite considerable theoretical progress in the training of neural networks viewed as a multi-agent system of neurons, particularly concerning biological plausibility and decentralized training, their applicability to real-world problems…

Neural and Evolutionary Computing · Computer Science 2023-10-17 Arshia Soltani Moakhar , Mohammad Azizmalayeri , Hossein Mirzaei , Mohammad Taghi Manzuri , Mohammad Hossein Rohban

Deep Learning's outstanding track record across several domains has stemmed from the use of error backpropagation (BP). Several studies, however, have shown that it is impossible to execute BP in a real brain. Also, BP still serves as an…

Machine Learning · Computer Science 2021-06-11 Swaroop Mishra , Anjana Arunkumar
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