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Generative modeling of three-dimensional (3D) molecules is a fundamental yet challenging problem in drug discovery and materials science. Existing approaches typically represent molecules as 3D graphs and co-generate discrete atom types…

Machine Learning · Statistics 2026-03-16 Yuchen Hua , Xingang Peng , Jianzhu Ma , Muhan Zhang

The future astronomical imaging surveys are set to provide precise constraints on cosmological parameters, such as dark energy. However, production of synthetic data for these surveys, to test and validate analysis methods, suffers from a…

Neural network potentials (NNPs) enable large-scale molecular dynamics (MD) simulations of systems containing >10,000 atoms with the accuracy comparable to ab initio methods and play a crucial role in material studies. Although NNPs are…

This paper introduces a 3D shape generative model based on deep neural networks. A new image-like (i.e., tensor) data representation for genus-zero 3D shapes is devised. It is based on the observation that complicated shapes can be well…

Computer Vision and Pattern Recognition · Computer Science 2019-03-05 Heli Ben-Hamu , Haggai Maron , Itay Kezurer , Gal Avineri , Yaron Lipman

We introduce a deep generative network for 3D shape detailization, akin to stylization with the style being geometric details. We address the challenge of creating large varieties of high-resolution and detailed 3D geometry from a small set…

Computer Vision and Pattern Recognition · Computer Science 2021-03-30 Zhiqin Chen , Vladimir G. Kim , Matthew Fisher , Noam Aigerman , Hao Zhang , Siddhartha Chaudhuri

We present a deep generative scene modeling technique for indoor environments. Our goal is to train a generative model using a feed-forward neural network that maps a prior distribution (e.g., a normal distribution) to the distribution of…

Computer Vision and Pattern Recognition · Computer Science 2018-08-08 Zaiwei Zhang , Zhenpei Yang , Chongyang Ma , Linjie Luo , Alexander Huth , Etienne Vouga , Qixing Huang

This work introduces a novel system for the generation of images that contain multiple classes of objects. Recent work in Generative Adversarial Networks have produced high quality images, but many focus on generating images of a single…

Machine Learning · Computer Science 2019-11-11 Elijah D. Bolluyt , Cristina Comaniciu

Generative networks have shown remarkable success in learning complex data distributions, particularly in generating high-dimensional data from lower-dimensional inputs. While this capability is well-documented empirically, its theoretical…

Machine Learning · Computer Science 2025-04-02 Kevin Wang , Hongqian Niu , Yixin Wang , Didong Li

Generative models for 2D images has recently seen tremendous progress in quality, resolution and speed as a result of the efficiency of 2D convolutional architectures. However it is difficult to extend this progress into the 3D domain since…

Computer Vision and Pattern Recognition · Computer Science 2022-10-07 Hassan Abu Alhaija , Alara Dirik , André Knörig , Sanja Fidler , Maria Shugrina

Proteins are macromolecules that mediate a significant fraction of the cellular processes that underlie life. An important task in bioengineering is designing proteins with specific 3D structures and chemical properties which enable…

Quantitative Methods · Quantitative Biology 2022-05-31 Namrata Anand , Tudor Achim

Recently, molecule generation using deep learning has been actively investigated in drug discovery. In this field, Transformer and VAE are widely used as powerful models, but they are rarely used in combination due to structural and…

Biomolecules · Quantitative Biology 2024-04-08 Yasuhiro Yoshikai , Tadahaya Mizuno , Shumpei Nemoto , Hiroyuki Kusuhara

Proteins are essential macromolecules defined by their amino acid sequences, which determine their three-dimensional structures and, consequently, their functions in all living organisms. Therefore, generative protein modeling necessitates…

Machine Learning · Computer Science 2024-10-18 Xinyou Wang , Zaixiang Zheng , Fei Ye , Dongyu Xue , Shujian Huang , Quanquan Gu

Accurate protein structures are essential for understanding biological function, yet incorporating experimental data into protein generative models remains a major challenge. Most predictors of experimental observables are…

Machine Learning · Computer Science 2025-11-18 Nadav Bojan Sellam , Meital Bojan , Paul Schanda , Alex Bronstein

Numerous methods have been proposed for probabilistic generative modelling of 3D objects. However, none of these is able to produce textured objects, which renders them of limited use for practical tasks. In this work, we present the first…

Computer Vision and Pattern Recognition · Computer Science 2020-04-10 Paul Henderson , Vagia Tsiminaki , Christoph H. Lampert

Mass spectrometry plays a fundamental role in elucidating the structures of unknown molecules and subsequent scientific discoveries. One formulation of the structure elucidation task is the conditional de novo generation of molecular…

Machine Learning · Computer Science 2025-05-29 Montgomery Bohde , Mrunali Manjrekar , Runzhong Wang , Shuiwang Ji , Connor W. Coley

Previous approaches to generate shapes in a 3D setting train a GAN on the latent space of an autoencoder (AE). Even though this produces convincing results, it has two major shortcomings. As the GAN is limited to reproduce the dataset the…

Computer Vision and Pattern Recognition · Computer Science 2021-07-23 Moritz Ibing , Isaak Lim , Leif Kobbelt

3D multi object generative models allow us to synthesize a large range of novel 3D multi object scenes and also identify objects, shapes, layouts and their positions. But multi object scenes are difficult to create because of the dataset…

Computer Vision and Pattern Recognition · Computer Science 2019-03-11 Vedant Singh , Manan Oza , Himanshu Vaghela , Pratik Kanani

Designing new chemical compounds with desired pharmaceutical properties is a challenging task and takes years of development and testing. Still, a majority of new drugs fail to prove efficient. Recent success of deep generative modeling…

Machine Learning · Computer Science 2021-09-15 Karina Zadorozhny , Lada Nuzhna

Synthetic polymeric materials underpin fundamental technologies in the energy, electronics, consumer goods, and medical sectors, yet their development still suffers from prolonged design timelines. Although polymer informatics tools have…

Computational Engineering, Finance, and Science · Computer Science 2025-06-12 Ayush Jain , Rampi Ramprasad

As several industries are moving towards modeling massive 3D virtual worlds, the need for content creation tools that can scale in terms of the quantity, quality, and diversity of 3D content is becoming evident. In our work, we aim to train…

Computer Vision and Pattern Recognition · Computer Science 2022-09-23 Jun Gao , Tianchang Shen , Zian Wang , Wenzheng Chen , Kangxue Yin , Daiqing Li , Or Litany , Zan Gojcic , Sanja Fidler
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