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Recent work has shown that probabilistic models based on pairwise interactions-in the simplest case, the Ising model-provide surprisingly accurate descriptions of experiments on real biological networks ranging from neurons to genes.…

Quantitative Methods · Quantitative Biology 2007-12-18 Tamara Broderick , Miroslav Dudik , Gasper Tkacik , Robert E. Schapire , William Bialek

Diffusion models have become a successful approach for solving various image inverse problems by providing a powerful diffusion prior. Many studies tried to combine the measurement into diffusion by score function replacement, matrix…

Computer Vision and Pattern Recognition · Computer Science 2024-05-20 Hanyu Chen , Zhixiu Hao , Liying Xiao

The inverse Ising problem consists in inferring the coupling constants of an Ising model given the correlation matrix. The fastest methods for solving this problem are based on mean-field approximations, but which one performs better in the…

Disordered Systems and Neural Networks · Physics 2012-08-28 Federico Ricci-Tersenghi

Identifying model parameters from observed configurations poses a fundamental challenge in data science, especially with limited data. Recently, diffusion models have emerged as a novel paradigm in generative machine learning, capable of…

Data Analysis, Statistics and Probability · Physics 2025-03-14 Yechan Lim , Sangwon Lee , Junghyo Jo

The large amounts of data from molecular biology and neuroscience have lead to a renewed interest in the inverse Ising problem: how to reconstruct parameters of the Ising model (couplings between spins and external fields) from a number of…

Disordered Systems and Neural Networks · Physics 2012-08-13 H. Chau Nguyen , Johannes Berg

Recovering microscopic couplings directly from data provides a route to solving the inverse problem in statistical field theories, one that complements the traditional-often computationally intractable-forward approach of predicting…

Statistical Mechanics · Physics 2025-11-24 Shreya Shukla , Abhijith Jayakumar , Andrey Y. Lokhov

Learning Ising or Potts models from data has become an important topic in statistical physics and computational biology, with applications to predictions of structural contacts in proteins and other areas of biological data analysis. The…

Biological Physics · Physics 2018-09-19 Chen-Yi Gao , Hai-Jun Zhou , Erik Aurell

We formulate a novel approach to solve a class of stochastic problems, referred to as data-consistent inverse (DCI) problems, which involve the characterization of a probability measure on the parameters of a computational model whose…

Numerical Analysis · Mathematics 2024-04-19 Kirana Bergstrom , Troy Butler , Tim Wildey

Diffusion models have emerged as powerful generative priors for solving inverse imaging problems. However, their practical deployment is hindered by the substantial computational cost of slow, multi-step sampling. Although Consistency…

Image and Video Processing · Electrical Eng. & Systems 2025-12-04 Amirreza Tanevardi , Pooria Abbas Rad Moghadam , Seyed Mohammad Eshtehardian , Sajjad Amini , Babak Khalaj

The inverse Ising problem seeks to reconstruct the parameters of an Ising Hamiltonian on the basis of spin configurations sampled from the Boltzmann measure. Over the last decade, many applications of the inverse Ising problem have arisen,…

Disordered Systems and Neural Networks · Physics 2017-09-13 Johannes Berg

Dataset Condensation (DC) aims to reduce deep neural networks training efforts by synthesizing a small dataset such that it will be as effective as the original large dataset. Conventionally, DC relies on a costly bi-level optimization…

Computer Vision and Pattern Recognition · Computer Science 2024-12-09 Sahar Rahimi Malakshan , Mohammad Saeed Ebrahimi Saadabadi , Ali Dabouei , Nasser M. Nasrabadi

The inverse Ising problem and its generalizations to Potts and continuous spin models have recently attracted much attention thanks to their successful applications in the statistical modeling of biological data. In the standard setting,…

Quantitative Methods · Quantitative Biology 2017-03-06 Pierre Barrat-Charlaix , Matteo Figliuzzi , Martin Weigt

Unsupervised learning makes manifest the underlying structure of data without curated training and specific problem definitions. However, the inference of relationships between data points is frustrated by the `curse of dimensionality' in…

Inverse problems in statistical physics are motivated by the challenges of `big data' in different fields, in particular high-throughput experiments in biology. In inverse problems, the usual procedure of statistical physics needs to be…

Disordered Systems and Neural Networks · Physics 2017-11-07 H. Chau Nguyen , Riccardo Zecchina , Johannes Berg

In this paper we study the inference of the kinetic Ising model on sparse graphs by the decimation method. The decimation method, which was first proposed in [Phys. Rev. Lett. 112, 070603] for the static inverse Ising problem, tries to…

Disordered Systems and Neural Networks · Physics 2016-06-30 Aurélien Decelle , Pan Zhang

Diffusion Inverse Solvers (DIS) are designed to sample from the conditional distribution $p_{\theta}(X_0|y)$, with a predefined diffusion model $p_{\theta}(X_0)$, an operator $f(\cdot)$, and a measurement $y=f(x'_0)$ derived from an unknown…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Tongda Xu , Ziran Zhu , Jian Li , Dailan He , Yuanyuan Wang , Ming Sun , Ling Li , Hongwei Qin , Yan Wang , Jingjing Liu , Ya-Qin Zhang

While the usual goal in Monte Carlo (MC) simulations of Ising models is the efficient generation of spin configurations with Boltzmann probabilities, the inverse problem is to determine the coupling constants from a given set of spin…

Disordered Systems and Neural Networks · Physics 2017-05-24 Joseph Albert , Robert H. Swendsen

Variational regularization of ill-posed inverse problems is based on minimizing the sum of a data fidelity term and a regularization term. The balance between them is tuned using a positive regularization parameter, whose automatic choice…

Numerical Analysis · Mathematics 2025-11-12 Markus Juvonen , Bjørn Jensen , Ilmari Pohjola , Yiqiu Dong , Samuli Siltanen

We consider the inverse Ising problem, i.e. the inference of network couplings from observed spin trajectories for a model with continuous time Glauber dynamics. By introducing two sets of auxiliary latent random variables we render the…

Machine Learning · Statistics 2017-12-22 Christian Donner , Manfred Opper

Correlations between two variables of a high-dimensional system can be indicative of an underlying interaction, but can also result from indirect effects. Inverse Ising inference is a method to distinguish one from the other. Essentially,…

Populations and Evolution · Quantitative Biology 2014-12-10 Benedikt Obermayer , Erel Levine
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