Related papers: Defect-driven shape transitions in elastic active …
Active fluids, such as cytoskeletal filaments, bacterial colonies and epithelial cell layers, exhibit distinctive orientational coherence, often characterized by nematic order and topological defects. By contrast, little is known about…
Cells are fundamental building blocks of living organisms displaying an array of shapes, morphologies, and textures that encode specific functions and physical behaviors. Elucidating the rules of this code remains a challenge. In this work,…
A wide range of living and artificial active matter exists in close contact with substrates and under strong confinement, where in addition to dipolar active stresses, quadrupolar active stresses can become important. Here, we numerically…
Growing experimental evidence indicates that topological defects could serve as organizing centers in the morphogenesis of tissues. Here, we provide a quantitative explanation for this phenomenon, rooted in the buckling theory of deformable…
We numerically investigate how spatial variations of extensile or contractile active stress affect bulk active nematic systems in two and three dimensions. In the absence of defects, activity gradients drive flows which re-orient the…
There is now growing evidence of the emergence and biological functionality of liquid crystal features, including nematic order and topological defects, in cellular tissues. However, how such features that intrinsically rely on particle…
Morphogenesis of living systems involves topological shape transformations which are highly unusual in the inanimate world. Here we demonstrate that a droplet of a nematic liquid crystal changes its equilibrium shape from a simply-connected…
In confluent cell monolayers, patterns of cell forces and motion are systematically altered near topological defects in cell shape. In turn, defects have been proposed to alter cell density, extrusion, and invasion, but it remains unclear…
We show that topological defects in an ion-doped nematic liquid crystal can be used to manipulate the surface charge distribution on chemically homogeneous, charge-regulating external surfaces, using a minimal theoretical model. In…
Topological defects are a conspicuous feature of active liquid crystals that have been associated with important morphogenetic transitions in organismal development. Robust development thus requires a tight control of the motion and…
Topological defects in systems with liquid-crystalline order are crucial in determining their large-scale properties. In active systems, they are known to have properties impossible at equilibrium: for example, $+1/2$ defects in…
Active fluids display spontaneous turbulent-like flows known as active turbulence. Recent work revealed that these flows have universal features, independent of the material properties and of the presence of topological defects. However,…
Hydra, a centimeter long cylindrical-shaped freshwater organism, has emerged as an interesting model system for studying morphogenesis in animals. Recently, fluorescent imaging of cytoskeletal actin filaments on the outer surface of hydra…
We investigate the dynamics of active nematic liquid crystals on deformable membranes, focusing on the interplay between active stress and anisotropic curvature coupling. Using a minimal model, we simulate the coupled evolution of the…
The persistent dynamics in systems out of equilibrium, particularly those characterized by annihilation and creation of topological defects, is known to involve complicated spatiotemporal processes and is deemed difficult to control. Here…
Morphological trends in growing colonies of living cells are at the core of physiological and evolutionary processes. Using active gel equations, which include cell division, we show that shape changes during the growth can be regulated by…
How do topological defects affect the degree of order in active matter? To answer this question we investigate an agent-based model of self-propelled particles, which accounts for polar alignment and short-ranged repulsive interactions. For…
In pulsating active matter, topological defects are motile despite the absence of any macroscopic flows and microscopic self-propulsion. We reveal that this motility arises from a ratchet effect: the mechanochemical coupling between local…
Point-like motile topological defects control the universal dynamics of diverse two-dimensional active nematics ranging from shaken granular rods to cellular monolayers. A comparable understanding in higher dimensions has yet to emerge. We…
The emergence of nematic order on deformable closed surfaces plays a pivotal role in the morphogenesis of active biological matter, such as the regeneration of Hydra. In this work, we present a continuum model that couples the…